[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-326940-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-326940-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","genomic-alterations-in-oral-multiple-primary-cancers-research-study","Genomic alterations in oral multiple primary cancers - Research study","","Study data analyze clinicopathological features and genomic alterations in oral multiple primary cancers (MPCs), where etiology remains unclear. Patients with oral single primary carcinoma (SPC, n=202) and oral MPCs (n=34) were compared, using copy number alteration (CNA) to explore chromosomal-instability differences across groups. Whole-exome sequencing identified potential unique gene mutations, and CNA plus phylogenetic analyses assessed molecular similarities and differences between multiple primaries within individuals. Findings show worse long-term outcomes in oral MPCs, with sex predominance and additional less common mutations.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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study on oral MPCs?","Question",{"text":62,"@type":63},"To investigate clinicopathological characteristics and genomic alterations specific to oral multiple primary cancers.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were genomic alterations assessed in oral MPCs patients?",{"text":67,"@type":63},"Copy number alteration (CNA) analysis and whole-exome sequencing were used, followed by CNA and phylogenetic tree analyses to explore molecular patterns among tumors.",{"name":69,"@type":60,"acceptedAnswer":70},"What were key clinical findings regarding oral MPCs compared with oral SPC?",{"text":71,"@type":63},"Females predominated in oral MPCs, smoking and alcohol use were less frequent, and long-term survival outcomes were poorer in oral 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alterations in oral multiple primary cancers  \nXuan Zhou 1,2, Xinjia Cai1,2, Fengyang Jing1,2, Xuefen Li3, Jianyun Zhang 1,2, Heyu Zhang2,3 ✉ and Tiejun Li1,2 ✉  \n\n|  | Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n = 202) and oral MPCs (n = 34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in MPCs. Moreover, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct |  |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| differences of the similarity degree were observed between synchronous and metachronous oral MPCs. |  |  |\n|  | International Journal of Oral Science (2024)16:13 ; [https://doi.org/10.1038/s41368-023-00265-w](https://doi.org/10.1038/s41368-023-00265-w) |  |\n|  |  |  |\n\nINTRODUCTION  \nOral squamous cell carcinoma (OSCC) is the most prevalent histological subtype of oral cancer, encompassing malignancies that occur in the buccal mucosa, tongue, gingiva, larynx, palate, orlip. The clinical manifestations of OSCC vary depending on the specific cancer type, with some patients presenting with nonhealing nodules or sores in the oral mucosa.1 Others with tumors located in the pharynx or floor of the mouth may experience difficulties in swallowing or changes in vocal quality.2 Approximately 75% of OSCC are attributed to alcohol and tobacco use.3 Extensive research has been conducted on OSCC, including studies investigating its clinical presentations, etiology, and treatment strategies.  \nHowever, there exist a subset of patients who develop multiple primary cancers (MPCs) in the oral cavity, and the causes of this phenomenon remain unclear. The incidence of MPCs in OSCC ranges from 10 to 34% and contributes significantly to cancerrelated mortality.4 In 1932, Warren and Gates proposed diagnostic criteria for MPCs.5 Currently, the most commonly utilized definitions are provided by the Surveillance Epidemiology and End Results (SEER) project and the International Association of Cancer Registries and the International Agency for Research on Cancer (IACR/IARC) .6,7 The difference in diagnostic criteria between these two systems primarily lies in the statistical analysis of tumor locations. For example, while SEER treats tumors occurring in different parts of the colon as separate entities, the colon is considered a single location in the IACR/IARC system. Additionally, SEER recommends a 2-month interval to differentiate  \nsynchronous and metachronous MPCs, whereas the IACR/IARC suggests a cutoff of 6 months to clas","cbCaitFOvqM53azt","https://ap.wps.com/l/cbCaitFOvqM53azt","pdf",2072012,"English","# Introduction\n## Background on oral squamous cell carcinoma (OSCC)\n## Multiple primary cancers (MPCs) and diagnostic criteria\n## Prognostic differences and molecular identification","[{\"question\":\"What is the main objective of the study on oral MPCs?\",\"answer\":\"To investigate clinicopathological characteristics and genomic alterations specific to oral multiple primary cancers.\"},{\"question\":\"How were genomic alterations assessed in oral MPCs patients?\",\"answer\":\"Copy number alteration (CNA) analysis and whole-exome sequencing were used, followed by CNA and phylogenetic tree analyses to explore molecular patterns among tumors.\"},{\"question\":\"What were key clinical findings regarding oral MPCs compared with oral SPC?\",\"answer\":\"Females predominated in oral MPCs, smoking and alcohol use were less frequent, and long-term survival outcomes were poorer in oral MPCs.\"}]","Genomic alterations in oral multiple primary cancers - Research study | PDF",1789975821,23]