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This poster examines whether genetic liability for psychiatric disorders is associated with PFC thickness in Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and cognitively healthy controls. Associations were tested in 2,538 Amsterdam Dementia Cohort participants using FreeSurfer-derived PFC thickness and polygenic risk scores across diagnoses.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/genetic-risk-for-psychiatric-disorders-and-prefrontal-lobe-thickness-in-a-memory-clinic-population/455927/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/genetic-risk-for-psychiatric-disorders-and-prefrontal-lobe-thickness-in-a-memory-clinic-population/455927.png","ImageObject",300,407,{"name":92,"@type":93},"Taylor Morgan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study investigate?","Question",{"text":112,"@type":113},"It investigates whether genetic liability for psychiatric disorders is associated with prefrontal lobe (PFC) thickness across AD, DLB, FTD, and cognitively healthy controls.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were genetic risk and brain structure measured?",{"text":117,"@type":113},"Polygenic risk scores for depression, bipolar disorder, schizophrenia, and autism were calculated using LDpred2 with GWAS weights, and PFC thickness was processed from 3DT1w MRI using FreeSurfer with Desikan-Killiany labels.",{"name":119,"@type":110,"acceptedAnswer":120},"Were any associations statistically significant?",{"text":121,"@type":113},"No significant main effects were observed between polygenic risk scores and PFC thickness. However, schizophrenia PRS interacted with DLB status for lateral orbitofrontal cortex thickness, with higher SCZPRS associated with reduced lateral OFC thickness in DLB patients.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455927,1790800844,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},1099523885336,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","DOI: 10. 1002/alz70856_105421  \nBIOMARKERS  \nPOSTER PRESENTATION  \nNEUROIMAGING  \nGenetic risk for psychiatric disorders and prefrontal lobe thickness in a memory clinic population  \nJenna Najar1, 2, 3  \nBetty M. Tijms6  \n Ellen Dicks3, 4  AfinaW. Lemstra3, 4  Wiesje M. van der Flier5   \n Yolande A. L. Pijnenburg7  Sven J van der Lee 1, 3  Lianne M. Reus3, 4, 8  \n1 Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Amsterdam UMC, Amsterdam, Netherlands  \n2 Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden  \n3Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands  \n4Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Noord-Holland, Netherlands  \n5Alzheimer Center Amsterdam, Neurology, Amsterdam UMC Location VUmc, Vrije Universiteit Amsterdam, Amsterdam, Netherlands  \n6Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Noord-Holland, Netherlands  \n7Alzheimer Center Amsterdam, Department of Neurology, Amsterdam UMC, location VUmc, Amsterdam, Netherlands  \n8 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA, Los Angeles, CA, USA  \nCorrespondence  \nJenna Najar, Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Amsterdam UMC, Amsterdam, Netherlands. [Email:](Email: jenna.najar@gu.se)[ jenna.najar@gu.se](Email: jenna.najar@gu.se)  \nAbstract  \nBackground: Psychiatric disordersand dementia share overlapping clinical and genetic factors (e.g., SNCA, CLU, and APOE), and both conditions implicating the prefrontal cortex (PFC). We examined the association between genetic liability for psychiatric disorders and PFC thickness in Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and cognitively healthy controls.  \nMethod: We analyzed 2,538 individuals (1,258 AD, 169 DLB, 238 FTD, and 873 controls) from the Amsterdam Dementia Cohort. 3DT1w images were processed with FreeSurfer (version 7.1. 1) and labels for PFC correspond to those from the DesikanKiliany atlas. The segmentation of all images were visually quality checked. Polygenic risk scores (PRS) for depression (MDDPRS), bipolar disorder (BDPRS), schizophrenia (SCZPRS), and autism (ASDPRS) were calculated using LDpred2, with weights from independent GWAS. Linear mixed models were used to test associations between PRSand PFC thickness, using PRS*hemisphere, PRS*diagnostic group, age, sex, scanner model, and total gray matter volume as fixed effects and hemisphere as random effect. Result: No significant main effects were observed between PRS and PFC thickness. Hemisphere did not influence the relationship for BDPRS, SCZPRS, or ASDPRS. MDDPRS interacted with hemisphere in relation toPFC, showing positive associationsin the left hemisphere and negative in right, although no association reached significance. SCZPRS interacted with DLB case-control status in relation to lateral orbitofrontal cortex (OFC) thickness, showing that higher SCZPRS associated with reduced lateral OFC thickness in DLB patients (B=-0.05, p = 0.003), but not in controls (B=0.003, p = 0. 6). Additionally, ASDPRS interacted with FTD in relation to PFC regions, although stratified models did not reach significance.  \nConclusion: The finding thatSCZPRS is associated with reduced lateral OFC thickness in DLB patients suggests a potential genetic basis for psychotic symptoms in DLBand contributes to understanding the neurobiological overlap between DLB and schizophrenia.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodi","cbCaivL9Hvmw2oDg","https://ap.wps.com/l/cbCaivL9Hvmw2oDg","pdf",311708,"English","# Abstract\n## Background\n## Method\n## Result\n## Conclusion","[{\"question\":\"What does the study investigate?\",\"answer\":\"It investigates whether genetic liability for psychiatric disorders is associated with prefrontal lobe (PFC) thickness across AD, DLB, FTD, and cognitively healthy controls.\"},{\"question\":\"How were genetic risk and brain structure measured?\",\"answer\":\"Polygenic risk scores for depression, bipolar disorder, schizophrenia, and autism were calculated using LDpred2 with GWAS weights, and PFC thickness was processed from 3DT1w MRI using FreeSurfer with Desikan-Killiany labels.\"},{\"question\":\"Were any associations statistically significant?\",\"answer\":\"No significant main effects were observed between polygenic risk scores and PFC thickness. However, schizophrenia PRS interacted with DLB status for lateral orbitofrontal cortex thickness, with higher SCZPRS associated with reduced lateral OFC thickness in DLB patients.\"}]","Genetic risk for psychiatric disorders and prefrontal lobe thickness in a memory clinic population | PDF",1790744695]