[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-625586-105":59,"doc-detail-625586-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","genetic-epilepsy-syndromes","Genetic Epilepsy Syndromes","","PURPOSE OF REVIEW: The article reviews clinical features, typical EEG findings, treatment strategies, prognosis, and molecular etiologies of common genetic epilepsy syndromes. It covers genetic generalized epilepsy, self-limited focal epilepsy of childhood, self-limited neonatal and infantile epilepsy, developmental and epileptic encephalopathies, progressive myoclonus epilepsies, sleep-related hypermotor epilepsy, photosensitive occipital lobe epilepsy, and focal epilepsy with auditory features. Recent findings highlight genetic mechanisms, emerging therapies, and precision medicine.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/genetic-epilepsy-syndromes/625586/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/genetic-epilepsy-syndromes/625586.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-10-20",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which genetic epilepsy syndromes does the review cover?","Question",{"text":112,"@type":113},"The review discusses genetic generalized epilepsy, self-limited focal epilepsy of childhood, self-limited neonatal and infantile epilepsy, select developmental and epileptic encephalopathies, progressive myoclonus epilepsies, sleep-related hypermotor epilepsy, photosensitive occipital lobe epilepsy, and focal epilepsy with auditory features. It also reviews two familial epilepsy syndromes: genetic epilepsy with febrile seizures plus and familial focal epilepsy with variable foci.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What EEG and imaging characteristics are described for genetic generalized epilepsy?",{"text":117,"@type":113},"Genetic generalized epilepsy syndromes are characterized by normal background activity and interictal generalized epileptiform discharges on EEG, and brain imaging is almost always normal.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the article describe recent progress and its impact on treatment and prognosis?",{"text":121,"@type":113},"It reports considerable advances in understanding genetic factors underlying genetic epilepsy syndromes. New therapies are emerging for some conditions, and precision medicine approaches may dramatically improve prognosis in certain cases.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},625586,1793128893,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Genetic Epilepsy Syndromes  \nBy Kenneth A. Myers, MD, PhD, FRCPC, CSCN(EEG)  \nABSTRACT  \nPURPOSE OF REVIEW: This article reviews the clinical features, typical EEG findings, treatment, prognosis, and underlying molecular etiologies of the more common genetic epilepsy syndromes. Genetic generalized epilepsy, self-limited focal epilepsy of childhood, self-limited neonatal and infantile epilepsy, select developmental and epileptic encephalopathies, progressive myoclonus epilepsies, sleep-related hypermotor epilepsy, photosensitive occipital lobe epilepsy, and focal epilepsy with auditory features are discussed. Also reviewed are two familial epilepsy syndromes: genetic epilepsy with febrile seizures plus and familial focal epilepsy with variable foci.  \nRECENT FINDINGS: Recent years have seen considerable advances in our understanding of the genetic factors underlying genetic epilepsy syndromes. New therapies are emerging for some of these conditions; in some cases, these precision medicine approaches may dramatically improve the prognosis.  \nSUMMARY: Many recognizable genetic epilepsy syndromes exist, the identification of which is a crucial skill for neurologists, particularly those who work with children. Proper diagnosis of the electroclinical syndrome allows for appropriate treatment choices and counseling regarding prognosis and possible comorbidities.  \nINTRODUCTION  \nA  \nlthough epilepsy is an etiologically heterogeneous condition, the importance of genetic factors has been acknowledged for many decades.1 This is perhaps clearest in the case of generalized epilepsy, where the risk in first-degree relatives is 5-to 10-fold greater than the general population.2-4 In twin studies, the concordance rate is  \nsignificantly higher for monozygotic compared with dizygotic twins.5-8 Epilepsy inheritance can follow a Mendelian pattern (ie, autosomal dominant, autosomal recessive, or X-linked); however, in many cases the pattern appears more complex, likely involving polygenic inheritance and epigenetic factors.1,9  \nIn many epilepsy syndromes, the underlying cause is known or assumed to be genetic. These conditions include both self-limited (formerly termed benign) phenotypes and more severe conditions, such as developmental and epileptic encephalopathies. This article reviews the clinical and electrographic aspects of these syndromes, as well as what is known about the underlying molecular factors.  \nREVIEW ARTICLE  \n􀀁  \nCONTINUUM AUDIO INTERVIEW AVAILABLE ONLINE  \nCITE AS:  \nCONTINUUM (MIN NEA P M INN) 2022;28(2, EPILEPSY):339–362.  \nAddress correspondence to Dr Kenneth A. Myers, Montreal Children's Hospital, 1001 Décarie  \nBlvd, Montreal, Quebec, H4A 3J1, Canada, [kenneth.myers@mcgill.ca](kenneth.myers@mcgill.ca).  \nRELATIONSHIP DISCLOSURE : Dr Myers has received personal compensation in the range of $500 to $4999 for serving as an academic writer with Springer Publishing Company. The institution of Dr Myers has received research support from Dravet Canada, Fonds de recherche du Québec, Koolen-de Vries Syndrome Foundation, The Liam  \nFoundation, and the Savoy  \nFoundation.  \nUNLABELED USE OF PRODUCTS/INVESTIGATIONAL USE DISCLOSURE :  \nDr Myers discusses the unlabeled/investigational use ofclobazam for the treatment of forms of epilepsy other than Lennox-Gastaut syndrome and quinidine for the treatment of epilepsy due to KCNT1  \npathogenic variants.  \n© 2022 American Academy of Neurology.  \nCONTINUUM JOURNAL . COM 339  \nCopyright © American Academy of Neurology. Unauthorized reproduction of this article is prohibited.  \nGENETIC EPILEPSY SYNDROMES  \nGENETIC GENERALIZED EPILEPSIES  \nAlso known as idiopathic generalized epilepsies, the genetic generalized epilepsy syndromes comprise a group of disorders that share some common clinical andelectrophysiologic factors (TABLE 4-1) . In the 2017 International League Against Epilepsy (ILAE) epilepsy classification, genetic generalized epilepsy was described as the more accurate nomenclature","cbCair91Hvfue7rX","https://ap.wps.com/l/cbCair91Hvfue7rX","pdf",8859604,24,"English","# Abstract\n# Introduction\n# Review Article\n# Genetic Generalized Epilepsies","[{\"question\":\"Which genetic epilepsy syndromes does the review cover?\",\"answer\":\"The review discusses genetic generalized epilepsy, self-limited focal epilepsy of childhood, self-limited neonatal and infantile epilepsy, select developmental and epileptic encephalopathies, progressive myoclonus epilepsies, sleep-related hypermotor epilepsy, photosensitive occipital lobe epilepsy, and focal epilepsy with auditory features. It also reviews two familial epilepsy syndromes: genetic epilepsy with febrile seizures plus and familial focal epilepsy with variable foci.\"},{\"question\":\"What EEG and imaging characteristics are described for genetic generalized epilepsy?\",\"answer\":\"Genetic generalized epilepsy syndromes are characterized by normal background activity and interictal generalized epileptiform discharges on EEG, and brain imaging is almost always normal.\"},{\"question\":\"How does the article describe recent progress and its impact on treatment and prognosis?\",\"answer\":\"It reports considerable advances in understanding genetic factors underlying genetic epilepsy syndromes. New therapies are emerging for some conditions, and precision medicine approaches may dramatically improve prognosis in certain cases.\"}]","Genetic Epilepsy Syndromes | PDF",1792531664]