[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-32094":3,"doc-seo-32094":28},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":19,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"table_of_contents":24,"faqs":25,"seo_title":13,"seo_description":14,"update_tm":26,"read_time":27},32094,8796095360427,"Lucas Martin","https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d",8,"Research & Report","Genetic and Epigenetic Damage in Human Spermatozoa 2nd Edition","Male gamete production requires proper chromatin maturation during spermiogenesis to protect paternal DNA for delivery to the oocyte and to enable decondensation after fertilization. Genetic abnormalities and sperm epigenome damage can arise during sperm development and life, including effects of assisted reproduction manipulation and gonadotoxic therapies. The book provides an updated overview of sperm chromatin damage, covering de novo mutations, DNA strand breaks, oxidative processes, epigenetic mechanisms, and consequences for progeny health and male fertility status, with attention to prevention and interventions to reduce DNA fragmentation.","cbCaiixx8EKGEfvd","https://ap.wps.com/l/cbCaiixx8EKGEfvd","pdf",4605941,3,1,216,"English","en","# Preface\n## Goal and scope of the book\n# Contents\n## Genetic Factors Affecting Sperm Chromatin Structure\n## Age-Dependent De Novo Mutations During Spermatogenesis and Their Consequences\n## The Sperm Epigenome: Implications for Assisted Reproductive Technologies\n## Epigenetic Transgenerational Inheritance\n## Sperm DNA Fragmentation: Mechanisms of Origin\n## Sperm DNA Fragmentation: Consequences for Reproduction\n## Oxidative Damage to Sperm DNA: Attack and Defense\n## Interventions to Prevent Sperm","[{\"question\":\"What is the book’s central goal regarding sperm genome integrity?\",\"answer\":\"It focuses on how proper chromatin maturation during spermiogenesis protects paternal DNA for the long journey to the oocyte and supports proper formation of the male pronucleus after fertilization.\"},{\"question\":\"How can genetic abnormalities in sperm arise?\",\"answer\":\"Genetic abnormalities can be generated in any phase of sperm production and life, due to endogenous and exogenous conditions, including in vitro manipulation in assisted reproduction and gonadotoxic therapies.\"},{\"question\":\"What topics are covered about sperm epigenome and DNA damage?\",\"answer\":\"The book reviews mechanisms producing de novo mutations, DNA strand breaks, and oxidation, and includes dedicated chapters on sperm epigenome/epigenetic damage and their consequences for the progeny, along with interventions aimed at reducing sperm DNA fragmentation.\"}]",1780866084,544,{"code":4,"msg":29,"data":30},"ok",{"site_id":31,"language":23,"slug":32,"title":13,"keywords":33,"description":14,"schema_data":34,"social_meta":85,"head_meta":87,"extra_data":89,"updated_unix":26},105,"genetic-and-epigenetic-damage-in-human-spermatozoa-2nd-edition","",{"@graph":35,"@context":84},[36,52,67],{"@type":37,"itemListElement":38},"BreadcrumbList",[39,43,47,49],{"item":40,"name":41,"@type":42,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":44,"name":45,"@type":42,"position":46},"https://docshare.wps.com/document/","Document",2,{"item":48,"name":12,"@type":42,"position":19},"https://docshare.wps.com/document/research-report/",{"item":50,"name":13,"@type":42,"position":51},"https://docshare.wps.com/document/genetic-and-epigenetic-damage-in-human-spermatozoa-2nd-edition/32094/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":61,"encodingFormat":59,"isAccessibleForFree":62,"interactionStatistic":63},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":40,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-06-14","2026-06-07",true,{"@type":64,"interactionType":65,"userInteractionCount":19},"InteractionCounter",{"@type":66},"ViewAction",{"@type":68,"mainEntity":69},"FAQPage",[70,76,80],{"name":71,"@type":72,"acceptedAnswer":73},"What is the book’s central goal regarding sperm genome integrity?","Question",{"text":74,"@type":75},"It focuses on how proper chromatin maturation during spermiogenesis protects paternal DNA for the long journey to the oocyte and supports proper formation of the male pronucleus after fertilization.","Answer",{"name":77,"@type":72,"acceptedAnswer":78},"How can genetic abnormalities in sperm arise?",{"text":79,"@type":75},"Genetic abnormalities can be generated in any phase of sperm production and life, due to endogenous and exogenous conditions, including in vitro manipulation in assisted reproduction and gonadotoxic therapies.",{"name":81,"@type":72,"acceptedAnswer":82},"What topics are covered about sperm epigenome and DNA damage?",{"text":83,"@type":75},"The book reviews mechanisms producing de novo mutations, DNA strand breaks, and oxidation, and includes dedicated chapters on sperm epigenome/epigenetic damage and their consequences for the progeny, along with interventions aimed at reducing sperm DNA fragmentation.","https://schema.org",{"og:url":50,"og:type":86,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":88,"canonical":50},"index,follow",{"doc_id":7,"site_id":31}]