[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-406768-105":59,"doc-detail-406768-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","generic-vs-brand-forms-of-direct-acting-antivirals-for-hepatitis-c-virus-treatment-in-egyptian-children-original-article","Generic vs brand forms of direct acting antivirals for hepatitis C virus treatment in Egyptian children - Original Article","","Direct acting antivirals have transformed hepatitis C virus (HCV) therapy, but brand formulations remain costly and can limit access in resource-limited settings such as Egypt. This retrospective analytical study evaluates the safety and efficacy of generic sofosbuvir/ledipasvir versus the brand regimen Harvoni® in Egyptian HCV-infected children and adolescents. All participants achieved sustained virologic response (SVR), with mild, transient adverse effects comparable between groups.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/generic-vs-brand-forms-of-direct-acting-antivirals-for-hepatitis-c-virus-treatment-in-egyptian-children-original-article/406768/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/generic-vs-brand-forms-of-direct-acting-antivirals-for-hepatitis-c-virus-treatment-in-egyptian-children-original-article/406768.png","ImageObject",300,407,{"name":92,"@type":93},"Bulrr","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study aim regarding hepatitis C treatment in Egyptian children?","Question",{"text":113,"@type":114},"To assess the safety and efficacy of the generic sofosbuvir/ledipasvir regimen and compare outcomes with the brand form in Egyptian HCV-infected children and adolescents.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which treatment regimens were compared in the retrospective study?",{"text":118,"@type":114},"The generic form of sofosbuvir/ledipasvir (Ledisbuvir) was compared with the brand form Harvoni®.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key findings on efficacy and adverse effects?",{"text":122,"@type":114},"All patients achieved sustained virologic response (SVR). Treatment side effects were mild, transient, and comparable between the generic and brand groups.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406768,1790718226,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},5909892115043,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | H | World Journal of\u003Cbr>Hepatology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Hepatol 2025 December 27; 17(12): 110726  \nDOI: 10.4254/wjh.v17.i12.110726 ISSN 1948-5182 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nGeneric vs brand forms of direct acting antivirals for hepatitis C virus treatment in Egyptian children  \nEngy Mogahed, Haytham Ghita, Afaf Enayet, Noha Yasin, Hanaa El-Karaksy  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C  \nNovelty: Grade C  \nCreativity or Innovation: Grade D  \nScientific Significance: Grade B  \nP-Reviewer: Ou XM, MD, PhD, China  \nReceived: June 18, 2025  \nRevised: July 17, 2025  \nAccepted: November 11, 2025  \nPublished online: December 27, 2025  \nProcessing time: 191 Days and 16.4 Hours  \nEngy Mogahed, Haytham Ghita, Afaf Enayet, Noha Yasin, Hanaa El-Karaksy, The Pediatric Hepatology Unit, Department of Pediatrics, Cairo University, Cairo 12613, Egypt  \nCorresponding author: Hanaa El-Karaksy, Professor, The Pediatric Hepatology Unit, Department of Pediatrics, Cairo University, 44 Mohy-Eldien Abo Elezz Street, Cairo 12613, [Egypt.](Egypt. hanaakaraksy@kasralainy.edu.eg)[ hanaakaraksy@kasralainy.edu.eg](Egypt. hanaakaraksy@kasralainy.edu.eg)  \nAbstract  \nBACKGROUND  \nDirect acting antivirals have revolutionized hepatitis C virus (HCV) treatment. However, the high price of the brand forms is a barrier for their use in resource limited countries as Egypt.  \nAIM  \nTo assess the safety and efficacy of the generic sofosbuvir (SOF)/ledipasvir (LED) in Egyptian HCV-infected children and to compare the results with the brand form.  \nMETHODS  \nThis analytical retrospective study included HCV infected children and adolescents aged 12-18 years or weighing > 35 kg. Collected data included: Age, sex, risk factors of HCV acquisition, comorbidities, liver functions, HCV viral load, degree of hepatic fibrosis, sustained virologic response (SVR) and frequency of treatment adverse effects. Patients who received the generic form of SOF/LED (Ledisbuvir) were compared to patients who received the brand form (Harvoni®) regarding SVR and frequency of adverse events.  \nRESULTS  \nThe study included 43 patients who received Ledisbuvir and 73 who received Harvoni® . All patients achieved SVR. Treatment side effects were mild, transient and comparable in both groups.  \nCONCLUSION  \nThe use of generic SOF/LED in HCV infected children is safe and effective. It is comparable to the brand form at a reduced price and represents an affordable and effective alternative.  \n WJH  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 27, 2025  Volume 17  Issue 12   \nMogahed E et al. Generic vs brand forms of DAAs for HCV treatment  \nKey Words: Children; Direct acting antivirals; Generic; Hepatitis C virus; Ledipasvir; Sofosbuvir  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Direct acting antivirals have revolutionized hepatitis C virus (HCV) treatment. The high price of the brand forms is a barrier for their use in resource limited countries. The use of the generic forms of direct acting antivirals in adult treatment programs has increased treatment coverage and changed the disease burden. Scanty data are available for their use in children. Our findings support the use of the generic form of sofosbuvir/ledipasvir in HCV infected children. The comparable efficacy and safety outcomes to the branded Harvoni® regimen, coupled with the cost advantages of generics, reinforce their value in national HCV control strategies.  \nCitation: Mogahed E, Ghita H, Enayet A, Yasin N, El-Karaksy H. Generic vs brand forms of direct acting antivirals for hepatitis C virus treatment in Egyptian children. World J Hepatol 2025; 17(12","cbCaih3anPOdYBUJ","https://ap.wps.com/l/cbCaih3anPOdYBUJ","pdf",413506,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip\n# Introduction","[{\"question\":\"What was the study aim regarding hepatitis C treatment in Egyptian children?\",\"answer\":\"To assess the safety and efficacy of the generic sofosbuvir/ledipasvir regimen and compare outcomes with the brand form in Egyptian HCV-infected children and adolescents.\"},{\"question\":\"Which treatment regimens were compared in the retrospective study?\",\"answer\":\"The generic form of sofosbuvir/ledipasvir (Ledisbuvir) was compared with the brand form Harvoni®.\"},{\"question\":\"What were the key findings on efficacy and adverse effects?\",\"answer\":\"All patients achieved sustained virologic response (SVR). Treatment side effects were mild, transient, and comparable between the generic and brand groups.\"}]","Generic vs brand forms of direct acting antivirals for hepatitis C virus treatment in Egyptian children - Original Article | PDF",1790567736]