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Surveillance, Epidemiology, and End Results (SEER) data (2004–2021) were analyzed to quantify age-adjusted incidence and mortality trends by patient demographics, stage at diagnosis, treatment context proxies, and survival-related outcomes. Joinpoint loglinear regression and Poisson regression evaluated average percent changes and rate ratios across gender, race/ethnicity, and staging, with stratified interaction effects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gender-racial-and-stage-specific-trends-in-esophageal-cancer-insights-from-longitudinal-population-data-original-article/406558/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gender-racial-and-stage-specific-trends-in-esophageal-cancer-insights-from-longitudinal-population-data-original-article/406558.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of this study on esophageal cancer?","Question",{"text":112,"@type":113},"To analyze trends in esophageal cancer using SEER data, focusing on patient characteristics, stage at diagnosis, treatment modalities, and survival outcomes to inform clinical practice and public health initiatives.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which statistical methods were used to evaluate trends and associations?",{"text":117,"@type":113},"Age-adjusted incidence and mortality rates (2004–2021) were assessed with Joinpoint loglinear regression to estimate average percent changes, and Poisson regression was used to determine incidence and mortality rate ratios, including stratification by gender.",{"name":119,"@type":110,"acceptedAnswer":120},"What key differences were observed in incidence and mortality across demographic and stage groups?",{"text":121,"@type":113},"Incidence and mortality were higher in males than females, with notable variations by race/ethnicity and stage. Mortality increased with age, and distant-stage diagnosis showed a substantially higher mortality rate than in situ cases.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406558,1790821596,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","| W | J | G | P | World Journal of\u003Cbr>Gastrointestinal Pathophysiology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Pathophysiol 2025 December 22; 16(4): 110243  \nDOI: 10.4291/wjgp.v16.i4.110243 ISSN 2150-5330 (online)  \nORIGINAL ARTICLE  \nProspective Study  \nGender, racial, and stage-specific trends in esophageal cancer: Insights from longitudinal population data  \nSilpa Choday, Anthony Yeung, Paul Kang, Tina Younger, Wael Youssef  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade A  \nNovelty: Grade B, Grade B  \nCreativity or Innovation: Grade A, Grade A  \nScientific Significance: Grade A, Grade A  \nP-Reviewer: Feyissa GD, Assistant Professor, Ethiopia  \nReceived: June 3, 2025  \nRevised: July 17, 2025  \nAccepted: November 26, 2025  \nPublished online: December 22, 2025  \nProcessing time: 203 Days and 5.8 Hours  \nSilpa Choday, Anthony Yeung, Tina Younger, Department of Internal Medicine, Creighton University School of Medicine, Phoenix, AZ 85012, United States  \nPaul Kang, Department of Clinical Research and Public Health, Creighton University School of Medicine, Phoenix, AZ 85012, United States  \nWael Youssef, Department of Gastroenterology, Creighton University School of Medicine, Phoenix, AZ 85012, United States  \nCorresponding author: Silpa Choday, MD, Department of Internal Medicine, Creighton University School of Medicine, 3110 N Central Avenue, Phoenix, AZ 85012, United States.  \n[ushilpa19@gmail.com](ushilpa19@gmail.com)  \nAbstract  \nBACKGROUND  \nEsophageal cancer is a significant global health concern, characterized by high mortality rates and diverse histological types, primarily adenocarcinoma and squamous cell carcinoma.  \nAIM  \nTo analyze trends in esophageal cancer using Surveillance, Epidemiology, and End Results (SEER) data, focusing on patient characteristics, stage at diagnosis, treatment modalities, and survival outcomes, to provide insights that may guide clinical practice and public health initiatives.  \nMETHODS  \nAge-adjusted incidence and mortality rates for esophageal cancer, 2004-2021, were obtained from SEER rate sessions using SEER*Stat version 8.4.4. Average percent changes (APC) over time in age-adjusted incidence and mortality rates relative to gender, race/ethnicity, and stage at diagnosis were assessed using Joinpoint’s loglinear regression. Finally, Poisson regression was used to ascertain incidence and mortality rate ratios to ascertain associations between age, gender, race/ethnicity, and staging with incidence and mortality rates. All analyses were further stratified by gender to assess interactions between gender and the other demographic and clinical characteristics.  \nRESULTS  \nOverall, the data reveals significant trends in both the incidence and mortality  \n WJGP  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 22, 2025  Volume 16  Issue 4   \nChoday S et al. Incidence, staging, and SRs  \nrates of esophageal cancer, with notable variations across gender, race, and stage at diagnosis. Age-adjusted incidence and mortality rates were higher in males compared to females (incidence: 4.1 per 100000 vs 0.9 per 100000, mortality: 3.4 per 100000 vs 0.7 per 100000), P \u003C 0.001. Furthermore, the APC among males decreased more significantly over time [APC (95%CI): -1.14 (-1.52 to-0.78); P \u003C 0.001] . Both non-Hispanic (NH) Blacks and NH Whites showed significant decreases in cancer incidence, with NH Blacks observing a 3.27% decline and NH Whites a 0.51% decline. Patients with distant staging had a 5% APC increase in mortality rates over time (P = 0.003) . Additionally, mortality rates increased with age, and all minority groups showed declines in incidence and mortality compared to NH Whites. Cancer diagnosed at a distan","cbCaifnlkwp4cth7","https://ap.wps.com/l/cbCaifnlkwp4cth7","pdf",2744969,13,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n## Core Tip","[{\"question\":\"What is the main objective of this study on esophageal cancer?\",\"answer\":\"To analyze trends in esophageal cancer using SEER data, focusing on patient characteristics, stage at diagnosis, treatment modalities, and survival outcomes to inform clinical practice and public health initiatives.\"},{\"question\":\"Which statistical methods were used to evaluate trends and associations?\",\"answer\":\"Age-adjusted incidence and mortality rates (2004–2021) were assessed with Joinpoint loglinear regression to estimate average percent changes, and Poisson regression was used to determine incidence and mortality rate ratios, including stratification by gender.\"},{\"question\":\"What key differences were observed in incidence and mortality across demographic and stage groups?\",\"answer\":\"Incidence and mortality were higher in males than females, with notable variations by race/ethnicity and stage. Mortality increased with age, and distant-stage diagnosis showed a substantially higher mortality rate than in situ cases.\"}]","Gender, racial, and stage-specific trends in esophageal cancer - Insights from longitudinal population data - ORIGINAL ARTICLE | PDF",1790566443,33]