[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-455743-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-455743-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","gd-eob-dtpa-enhanced-magnetic-resonance-imaging-for-assessing-liver-function-in-primary-biliary-cholangitis","Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging for Assessing Liver Function in Primary Biliary Cholangitis","","Prospective study evaluating whether gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) can assess liver function in primary biliary cholangitis (PBC). Seventy-five patients underwent shear wave elastography (SWE) and Gd-EOB-DTPA-enhanced MRI with signal intensity ratio (SIR) and contrast enhancement index (CEI) across portal venous, equilibrium, and hepatobiliary phases, then were compared with Child-Pugh grading and non-invasive fibrosis models. Imaging and SWE outperformed serum-based models in diagnostic performance.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/gd-eob-dtpa-enhanced-magnetic-resonance-imaging-for-assessing-liver-function-in-primary-biliary-cholangitis/455743/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/gd-eob-dtpa-enhanced-magnetic-resonance-imaging-for-assessing-liver-function-in-primary-biliary-cholangitis/455743.png","ImageObject",300,407,{"name":42,"@type":43},"Ophelia","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What imaging technique was assessed for liver function in PBC?","Question",{"text":63,"@type":64},"The study assessed Gd-EOB-DTPA-enhanced magnetic resonance imaging, using hepatobiliary-phase signal intensity ratio (SIRHBP) and contrast enhancement index (CEIHBP), together with shear wave elastography (SWE).","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients evaluated in the study?",{"text":68,"@type":64},"Seventy-five PBC patients underwent SWE and Gd-EOB-DTPA-enhanced MRI, and imaging metrics were calculated in portal venous, equilibrium, and hepatobiliary phases. Results were then compared with Child-Pugh grading and non-invasive fibrosis models.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the reported diagnostic performances for more severe Child-Pugh categories?",{"text":72,"@type":64},"For Child-Pugh C, AUC values were 0.889 for SWE, 0.778 for SIRHBP, and 0.761 for CEIHBP. For Child-Pugh B+C, AUC values were 0.919 for SWE, 0.809 for SIRHBP, and 0.814 for CEIHBP.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},455743,1791169693,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":124,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","[1573-4056/25](1573-4056/25 Send Orders for Reprints to reprints@benthamscience.net)[ Send Orders for Reprints to](1573-4056/25 Send Orders for Reprints to reprints@benthamscience.net)[ ](1573-4056/25 Send Orders for Reprints to reprints@benthamscience.net)[reprints@benthamscience.net](1573-4056/25 Send Orders for Reprints to reprints@benthamscience.net)  \n1  \nCurrent Medical Imaging  \nContent list available at: [https://benthamscience.com/journals/cmir](https://benthamscience.com/journals/cmir)  \nRESEARCH ARTICLE  \nGd-EOB-DTPA-Enhanced Magnetic Resonance Imaging for Assessing Liver Function in Primary Biliary Cholangitis  \nZhengjun Li1,\\#, Fan Zhang2,\\#, Weiting Lu2, Chao Lu1, Zheng Yuan2,* and Zhongqiu Wang1,*  \n1Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China  \n2Department of Infectious Diseases, Affiliated Hospital with Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China  \nAbstract:  \nIntroduction:  \nThis study aimed to detect the performance of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for assessing primary biliary cholangitis (PBC) .  \nMethods:  \nSeventy-five patients with PBC were included in this prospective study. Shear wave elastography (SWE) and Gd-EOB-DTPA-enhanced MRI were conducted, and then the signal intensity ratio (SIR) and contrast enhancement index (CEI) in different phases, including portal venous phase (PVP), equilibrium phase (EP), and hepatobiliary phase (HBP), were calculated. Afterward, the results were compared with Child-Pugh grading and non-invasive liver fibrosis models using the Kruskal-Wallis H test or Chi-squared test. The area under the curve (AUC) was applied to evaluate the diagnostic performance of SIRHBP, CEIHBP, and SWE across different Child-Pugh grades.  \nResults:  \nSWE (p\u003C0.001), SIR HBP (p\u003C0.001), CEIHBP (p\u003C0.001), APRI (p=0.002), and FIB-4(p\u003C0.001) showed significant differences in different Child-Pugh grades. Statistically significant differences were found in SIRHBP (p=0.005), CEIHBP (p=0.010), and FIB-4 (p=0.001) of different SWE levels. For the diagnosis of Child-Pugh C, the AUC of SWE, SIRHBP, and CEIHBP were 0.889, 0.778, and 0.761, respectively. Correspondingly, the sensitivity was 75.0%, 64.4%, and 54.2%, and the specificity was 94.9%, 100%, and 100%, respectively. For the diagnosis of Child-Pugh B+C, the AUC of SWE, SIRHBP, and CEIHBP were 0.919, 0.809, and 0.814, respectively.  \nDiscussion:  \nOur study confirmed that Gd-EOB-DTPA-enhanced MRI is an effective and objective method for assessing liver function in patients with PBC.  \nConclusion:  \nSIRHBP and CEIHBP could be regarded as a novel imaging biomarker to evaluate liver function. Gd-EOB-DTPA-enhanced MRI and SWE outperformed serum-based models in sensitivity and specificity, strengthening the value of imaging in clinical decision-making.  \nKeywords: Magnetic resonance imaging, Gd-EOB-DTPA, SWE, Primary biliary cholangitis, Liver function, Portal venous phase.  \n\n| Article History | Received: January 08, 2025 | Revised: April 26, 2025 | Accepted: May 02, 2025 |\n| --- | --- | --- | --- |\n\n1. INTRODUCTION  \nPrimary biliary cholangitis (PBC) is the most common autoimmune liver disease, characterized by chronic inflamma-  \n* Address correspondence to these authors at the Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China and Department of Infectious Diseases, Affiliated Hospital with Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China;  \nE-mails: [zhqwang001@qq.com](zhqwang001@qq.com), [nihaoyz86@163.com](nihaoyz86@163.com)  \n\\#These authors contributed equally to this work.  \ntion of small bile ducts [1] . It may result in fibrosis, cirrhosis, and eventually liver failure or liver cancer. The global prevalence of PBC is approximately 14.60 per 100000 population, while the incidence in the Asian-Pacific r","cbCaikhq7qdFCD5a","https://ap.wps.com/l/cbCaikhq7qdFCD5a","pdf",12533231,"English","# Introduction\n# Materials and Methods\n# Results\n# Discussion\n# Conclusion","[{\"question\":\"What imaging technique was assessed for liver function in PBC?\",\"answer\":\"The study assessed Gd-EOB-DTPA-enhanced magnetic resonance imaging, using hepatobiliary-phase signal intensity ratio (SIRHBP) and contrast enhancement index (CEIHBP), together with shear wave elastography (SWE).\"},{\"question\":\"How were patients evaluated in the study?\",\"answer\":\"Seventy-five PBC patients underwent SWE and Gd-EOB-DTPA-enhanced MRI, and imaging metrics were calculated in portal venous, equilibrium, and hepatobiliary phases. Results were then compared with Child-Pugh grading and non-invasive fibrosis models.\"},{\"question\":\"What were the reported diagnostic performances for more severe Child-Pugh categories?\",\"answer\":\"For Child-Pugh C, AUC values were 0.889 for SWE, 0.778 for SIRHBP, and 0.761 for CEIHBP. For Child-Pugh B+C, AUC values were 0.919 for SWE, 0.809 for SIRHBP, and 0.814 for CEIHBP.\"}]","Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging for Assessing Liver Function in Primary Biliary Cholangitis | PDF",1790744138,25]