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31(6): 100458  \nDOI: 10.3748/wjg.v31.i6.100458 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nLETTER TO THE EDITOR  \nGATIS score: An innovative prognostic score for rectal neuroendocrine neoplasms  \nDaniel Paramythiotis, Dimitrios Tsavdaris, Eleni Karlafti  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade C  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade B  \nP-Reviewer: Tunruttanakul S  \nReceived: August 16, 2024  \nRevised: November 11, 2024  \nAccepted: December 6, 2024  \nPublished online: February 14, 2025  \nProcessing time: 146 Days and 11.9 Hours  \nDaniel Paramythiotis, Dimitrios Tsavdaris, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece  \nEleni Karlafti, Department of Emergency, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece  \nEleni Karlafti, 1st Propaedeutic Department of Internal Medicine, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece  \nCorresponding author: Daniel Paramythiotis, Doctor, Full Professor, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, St. Kyriakidi 1, Thessaloniki 54636, [Greece.](Greece. danosprx@auth.gr)[ danosprx@auth.gr](Greece. danosprx@auth.gr)  \nAbstract  \nIn this article, we discussed the article by Zeng et al, published in a recent issue of the World Journal of Gastroenterology. The publication represents a significant advancement in the prognostic evaluation of rectal neuroendocrine neoplasms. The GATIS score is a single nomogram model that incorporates five key prognostic factors: Tumor grade; T stage; tumor size; age; and the prognostic nutritional index. This innovation optimizes the prognostic process, delivering more accurate predictions of overall survival and progression-free survival compared to traditional TNM staging and World Health Organization classification systems. The findings of the study were based on a retrospective analysis spanning 12 years and involving 1408 patients from 17 reference centers in China. In this editorial, we specifically examined the strengths and limitations of the study, the clinical implications of the GATIS score, and the questions arising from its conclusions.  \nKey Words: Rectal neuroendocrine neoplasm; Prognosis; Score; Overall survival; Progression-free survival  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 February 14, 2025  Volume 31  Issue 6   \nParamythiotis D et al. GATIS score for prognostication in R-NENs  \nCore Tip: The GATIS score enables a more robust prognostic evaluation of patients with rectal neuroendocrine neoplasms. This prognostic score evaluates key factors, such as tumor grade, T stage, tumor size, age, and the prognostic nutritional index, and surpasses traditional models in predicting overall and progression-free survival. This advancement highlights the value of personalized medicine and standardized prognostic evaluations in enhancing patient outcomes and clinical practice.  \nCitation: Paramythiotis D, Tsavdaris D, Karlafti E. GATIS score: An innovative prognostic score for rectal neuroendocrine neoplasms. World J Gastroenterol 2025; 31(6): 100458  \nURL: [https://www.wjgnet.com/1007-9327/full/v31/i6/100458.htm](https://www.wjgnet.com/1007-9327/full/v31/i6/100458.htm)  \nDOI: [https://dx.doi.org/10.3748/w","cbCaib2ocDcGQTgo","https://ap.wps.com/l/cbCaib2ocDcGQTgo","pdf",379249,"English","# Letter to the Editor\n## GATIS score: An innovative prognostic score for rectal neuroendocrine neoplasms","[{\"question\":\"What prognostic factors are included in the GATIS score?\",\"answer\":\"The GATIS score incorporates tumor grade, T stage, tumor size, age, and the prognostic nutritional index.\"},{\"question\":\"How does the GATIS score improve prediction compared with TNM or WHO classification?\",\"answer\":\"It is designed to provide more accurate estimates of overall survival and progression-free survival than traditional TNM staging and WHO classification systems.\"},{\"question\":\"What evidence is the GATIS score based on?\",\"answer\":\"The study evidence summarized in the editorial comes from a retrospective analysis over 12 years including 1408 patients from 17 reference centers in China.\"}]","GATIS score - An innovative prognostic score for rectal neuroendocrine neoplasms | PDF",1790216147,15]