[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331364-105":59,"doc-detail-331364-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","gastrointestinal-cancer-resistance-to-treatment-the-role-of-microbiota","Gastrointestinal cancer resistance to treatment - the role of microbiota","","Gastrointestinal malignancies are among the most harmful illnesses worldwide, with many patients diagnosed at advanced stages and receiving ineffective care. Gut microbiota, comprising thousands of bacterial and other microbial species and billions of microbes, can both support and hinder health by altering the efficacy of anticancer medications. Gut microbiota–driven changes are linked to resistance to immunotherapy and chemotherapy. Although existing studies clarify parts of these interactions, further research is needed to enable more effective therapeutic strategies with fewer complications. This review examines microbiota effects on chemotherapy, immunotherapy, and radiotherapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gastrointestinal-cancer-resistance-to-treatment-the-role-of-microbiota/331364/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gastrointestinal-cancer-resistance-to-treatment-the-role-of-microbiota/331364.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are gastrointestinal cancers often treated ineffectively?","Question",{"text":112,"@type":113},"Many gastrointestinal cancer patients are diagnosed at an advanced stage, leading to ineffective care outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can gut microbiota influence anticancer treatment effectiveness?",{"text":117,"@type":113},"Gut microbiota and microbiome-linked changes can alter anticancer medication efficacy, including responses to immunotherapy and chemotherapy.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment modalities does the review focus on regarding microbiota?",{"text":121,"@type":113},"The review examines the effects of human microbiota on chemotherapy, immunotherapy, radiotherapy, and related anticancer management.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331364,1790228914,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Kolahi Sadeghi et al.  \nInfectious Agents and Cancer (2024) 19:50 [https://doi.org/10.1186/s13027-024-00605-3](https://doi.org/10.1186/s13027-024-00605-3)  \nInfectious Agents and Cancer  \n REVIEW Open Access  \nGastrointestinal cancer resistance to treatment: the role of microbiota  \nLeila Kolahi Sadeghi1 , Fatemeh Vahidian2,3 , Majid Eterafi 1,4 and Elham Safarzadeh1,5*  \nAbstract  \nThe most common illnesses that adversely influence human health globally are gastrointestinal malignancies. The prevalence of gastrointestinal cancers (GICs) is relatively high, and the majority of patients receive ineffective care since they are discovered at an advanced stage of the disease. A major component of the human body is thought to be the microbiota of the gastrointestinal tract and the genes that make up the microbiome. The gut microbiota includes more than 3000 diverse species and billions of microbes. Each of them has benefits and drawbacks and been demonstrated to alter anticancer medication efficacy. Treatment of GIC with the help of the gut bacteria is effective while changes in the gut microbiome which is linked to resistance immunotherapy or chemotherapy. Despite significant studies and findings in this field, more research on the interactions between microbiota and response to treatment in GIC are needed to help researchers provide more effective therapeutic strategies with fewer treatment complication. In this review, we examine the effect of the human microbiota on anti-cancer management, including chemotherapy, immunotherapy, and radiotherapy.  \nKeywords Gastrointestinal cancer, Microbiota, Chemotherapy, Immunotherapy, Radiotherapy  \nIntroduction  \nGastrointestinal (GI) cancers, including malignancies of the esophagus, stomach, and colorectum, are among the most frequently occurring cancers in humans. Although they arise from distinct origins, these cancers display diverse clinical characteristics, while also sharing certain similarities [1]. The incidence of cancer caused by carcinogenic infections currently accounts for approximately 10–20% of new cancer cases. However, this percentage  \n*Correspondence: Elham Safarzadeh  \n[Safarzadehelham@yahoo.com](Safarzadehelham@yahoo.com); [E.safarzadeh@arums.ac.ir](E.safarzadeh@arums.ac.ir)  \n1 Cancer Immunology and Immunotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran  \n2 Faculty of Medicine, Laval University, Quebec, Canada  \n3 Centre de Recherche de I’Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Quebec, Canada  \n4 Students’ Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran  \n5 Department of Microbiology, Parasitology, and Immunology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran  \nis anticipated to rise in the future as researchers delve deeper into the field of cancer microbiome research. Through these studies, scientists are gaining a better understanding of how tumor-associated microbes play a significant role in the initiation and progression of cancer, as well as their potential to develop resistance against treatment methods [2].  \nThe human microbiota, consisting of trillions of cells such as bacteria, viruses, and fungi, is widely acknowledged for its influence on human well-being and illness. There are many different kinds of bacteria in the human microbiome. Including commensal, symbiotic, and pathogenic species, that inhabit various parts of the body such as the skin, oral cavity, and GI tract [3, 4]. The gut harbors the most abundant microbial community, which has prompted extensive research to comprehend the effects of gastrointestinal microbiota on various diseases [3]. This effect is achieved by a variety of mechanisms, including DNA damage, activation of oncogenic pathways, creation of carcinogenic metabolites, spure of chronic inflammation, and suppression of the body’s  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons","cbCairQpZWRdUN92","https://ap.wps.com/l/cbCairQpZWRdUN92","pdf",2591287,15,"English","# Introduction\n## Gastrointestinal (GI) cancers and infectious carcinogenesis\n## Gut microbiota and mechanisms affecting disease\n# Overview on gastrointestinal cancer\n## Malignant tu","[{\"question\":\"Why are gastrointestinal cancers often treated ineffectively?\",\"answer\":\"Many gastrointestinal cancer patients are diagnosed at an advanced stage, leading to ineffective care outcomes.\"},{\"question\":\"How can gut microbiota influence anticancer treatment effectiveness?\",\"answer\":\"Gut microbiota and microbiome-linked changes can alter anticancer medication efficacy, including responses to immunotherapy and chemotherapy.\"},{\"question\":\"What treatment modalities does the review focus on regarding microbiota?\",\"answer\":\"The review examines the effects of human microbiota on chemotherapy, immunotherapy, radiotherapy, and related anticancer management.\"}]","Gastrointestinal cancer resistance to treatment - the role of microbiota | PDF",1789992925,38]