[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-333554-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-333554-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","gastric-cancer-fibroblasts-affect-the-effect-of-immunotherapy-and-patient-prognosis-by-inducing-micro-vascular-production-original-research","Gastric cancer fibroblasts affect the effect of immunotherapy and patient prognosis by inducing micro-vascular production - Original Research","","Gastric cancer immunotherapy relies on the tumor microenvironment, yet therapeutic success is constrained and antiangiogenic approaches show limited efficacy. This study characterizes gastric cancer cancer-associated fibroblasts (CAFs) and addresses the lack of CAF-specific markers by constructing a CAF angiogenesis prognostic score (CAPS). Patient-derived CAFs were evaluated for angiogenesis-related functions, and differential genes were used to build CAPS. Validation across GEO datasets and HPA supported CAPS as an independent predictor, linking high CAPS to shorter overall survival, immune escape, and reduced immunotherapy effectiveness.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/gastric-cancer-fibroblasts-affect-the-effect-of-immunotherapy-and-patient-prognosis-by-inducing-micro-vascular-production-original-research/333554/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/gastric-cancer-fibroblasts-affect-the-effect-of-immunotherapy-and-patient-prognosis-by-inducing-micro-vascular-production-original-research/333554.png","ImageObject",300,407,{"name":42,"@type":43},"Maeve","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What problem does the study address in gastric cancer immunotherapy?","Question",{"text":63,"@type":64},"Immunotherapy success in gastric cancer is tightly linked to the tumor microenvironment, but effective prediction and CAF-specific targeting are limited. The study addresses the absence of CAF-specific markers that could guide prognosis and immunotherapy response.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the CAPS system developed?",{"text":68,"@type":64},"The study assessed patient-derived gastric cancer CAFs for angiogenesis-related promoting effects and identified CAF-angiogenesis-associated differentially expressed genes. CAPS was constructed using THBS1, SPARC, EDNRA, and VCAN, followed by gene- and protein-level validation.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the study find about CAPS and patient outcomes?",{"text":72,"@type":64},"Patients in the high-CAPS group had shorter overall survival than those in the low-CAPS group. The high-CAPS group also showed a greater tendency toward immune escape and reduced immunotherapy efficacy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333554,1790190572,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","TYPE Original Research PUBLISHED 08 July 2024  \nDOI 10.3389/fimmu.2024.1375013  \nOPEN ACCESS  \nEDITED BY  \nZhou Xunian,  \nMD Anderson Cancer Center, United States  \nREVIEWED BY  \nXiaodong Zou,  \nThe Chinese University of Hong Kong, Shenzhen, China  \nBingrui Li,  \nUniversity of Texas MD Anderson Cancer Center, United States  \nWanheng Zhang,  \nBaylor College of Medicine, United States Xiujie Liang,  \nUniversity of Pennsylvania, United States  \n*CORRESPONDENCE Qi Wang  \n[wangqi710@126.com](wangqi710@126.com)[ ](wangqi710@126.com)Xia Ding  \n [dingx@bucm.edu.cn](dingx@bucm.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 05 February 2024  \nACCEPTED 28 May 2024  \nPUBLISHED 08 July 2024  \nCITATION  \nXia Y, Wang X, Lin J, Li Y, Dong L, Liang X, Wang H-Y, Ding X and Wang Q (2024) Gastric cancer fibroblasts affect the effect of immunotherapy and patient prognosis by inducing micro-vascular production.  \nFront. Immunol. 15:1375013 .  \ndoi: 10.3389/fimmu.2024.1375013  \nCOPYRIGHT  \n© 2024 Xia, Wang, Lin, Li, Dong, Liang, Wang, Ding and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nGastric cancer fibroblasts affect the effect of immunotherapy and patient prognosis by inducing micro-vascular production  \nYan Xia 1†, Xiaolu Wang 1†, Jie Lin 1, Yuan Li 1, Lidan Dong 1, Xue Liang 1, Huai-Yu Wang 1, Xia Ding 2* and Qi Wang 1*  \n1 National Institute of Traditional Chinese Medicine (TCM) Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China, 2School of Traditional Chinese Medicine,  \nBeijing University of Chinese Medicine, Beijing, China  \nIntroduction: Immunotherapy is critical for treating many cancers, and its therapeutic success is linked to the tumor microenvironment. Although antiangiogenic drugs are used to treat gastric cancer (GC), their efficacy remains limited. Cancer-associated fibroblast (CAF)-targeted therapies complement immunotherapy; however, the lack of CAF-specific markers poses a challenge. Therefore, we developed a CAF angiogenesis prognostic score (CAPS) system to evaluate prognosis and immunotherapy response in patients with GC, aiming to improve patient stratification and treatment efficacy.  \nMethods: We assessed patient-derived GC CAFs for promoting angiogenesis using EdU, cell cycle, apoptosis, wound healing, and angiogenesis analysis.  \nResults: We then identified CAF-angiogenesis-associated differentiallyexpressed genes, leading to the development of CAPS, which included THBS1, SPARC, EDNRA, and VCAN. We used RT-qPCR to conduct gene-level validation, and eight GEO datasets and the HPA database to validate the CAPS system at the gene and protein levels. Six independent GEO datasets were utilized for validation. Overall survival time was shorter in the high- than the low-CAPS group. Immune microenvironment and immunotherapy response analysis showed that the high-CAPS group had a greater tendency toward immune escape and reduced immunotherapy efficacy than the low-CAPS group.  \nDiscussion: CAPS is closely associated with GC prognosis and immunotherapy outcomes. It is therefore an independent predictor of GC prognosis and immunotherapy efficacy.  \nKEYWORDS  \ngastric cancer, bioinformatics, cancer-associated fibroblasts, angiogenesis, micro-vascular  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nGastric cancer (GC) is a common digestive system malignancy and the leading cause of cancer-related deaths worldwide, with few effective treatments (1) . Immunotherapy involves a specific immune response to tumor cells, such as stimulation, i","cbCaicWtFKfVtGdZ","https://ap.wps.com/l/cbCaicWtFKfVtGdZ","pdf",10454293,18,"English","# Introduction\n## Immunotherapy and tumor microenvironment\n## Angiogenesis in cancer progression\n# Methods\n## Patient-derived CAF functional assays\n# Results\n## Differential genes and CAPS construction\n## Validation across datasets and databases\n# Discussion\n## CAPS as an independent predictor","[{\"question\":\"What problem does the study address in gastric cancer immunotherapy?\",\"answer\":\"Immunotherapy success in gastric cancer is tightly linked to the tumor microenvironment, but effective prediction and CAF-specific targeting are limited. The study addresses the absence of CAF-specific markers that could guide prognosis and immunotherapy response.\"},{\"question\":\"How was the CAPS system developed?\",\"answer\":\"The study assessed patient-derived gastric cancer CAFs for angiogenesis-related promoting effects and identified CAF-angiogenesis-associated differentially expressed genes. CAPS was constructed using THBS1, SPARC, EDNRA, and VCAN, followed by gene- and protein-level validation.\"},{\"question\":\"What does the study find about CAPS and patient outcomes?\",\"answer\":\"Patients in the high-CAPS group had shorter overall survival than those in the low-CAPS group. The high-CAPS group also showed a greater tendency toward immune escape and reduced immunotherapy efficacy.\"}]","Gastric cancer fibroblasts affect the effect of immunotherapy and patient prognosis by inducing micro-vascular production - Original Research | PDF",1790002978,45]