[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331031-105":59,"doc-detail-331031-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","garcinol-in-gastrointestinal-cancer-prevention-recent-advances-and-future-prospects","Garcinol in gastrointestinal cancer prevention: recent advances and future prospects","","Gastrointestinal cancers remain a major global health burden, with millions of new cases each year and poor overall outcomes despite therapeutic progress. The review evaluates garcinol, a polyisoprenylated benzophenone found in Garcinia species, as a potential agent for treating gastrointestinal malignancies. It summarizes anticancer activity across esophageal, gastric, colorectal, pancreatic, and liver cancers, including inhibition of metastasis, induction of apoptosis, and disruption of key molecular pathways, along with safety considerations and the role of nanotechnology to improve delivery and efficacy. The article highlights opportunities for optimizing delivery strategies, studying synergistic combinations, and completing clinical trials to support clinical translation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/garcinol-in-gastrointestinal-cancer-prevention-recent-advances-and-future-prospects/331031/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/garcinol-in-gastrointestinal-cancer-prevention-recent-advances-and-future-prospects/331031.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is garcinol and why is it considered for gastrointestinal cancer prevention?","Question",{"text":112,"@type":113},"Garcinol is a polyisoprenylated benzophenone naturally present in Garcinia species. The review discusses its potential anticancer effects against multiple gastrointestinal malignancies through multiple biological mechanisms.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does garcinol exert anticancer effects according to the review?",{"text":117,"@type":113},"The review reports that garcinol can inhibit metastasis, induce apoptosis, and affect key molecular pathways involved in cancer progression, including effects observed in several GI cancer types.",{"name":119,"@type":110,"acceptedAnswer":120},"What role does nanotechnology play for garcinol in this review?",{"text":121,"@type":113},"Nanotechnology is explored as a strategy to enhance garcinol delivery and improve efficacy, addressing therapeutic delivery challenges for clinical application.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331031,1790015315,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Journal of Cancer Research and Clinical Oncology (2024) 150:370  \n[https://doi.org/10.1007/s00432-024-05880-6](https://doi.org/10.1007/s00432-024-05880-6)  \nREVIEW  \nGarcinol in gastrointestinal cancer prevention: recent advances and future prospects  \nNitika Patwa1 · Ritu Chauhan2 · Abhishek Chauhan3 · Manoj Kumar4 · Seema Ramniwas5 · Darin Mansor Mathkor6 · Adesh Kumar Saini7 · Hardeep Singh Tuli7 · Shafiul Haque8 · Petr Slama9  \nReceived: 5 May 2024 / Accepted: 3 July 2024 / Published online: 27 July 2024 © The Author(s) 2024  \nAbstract  \nGastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies. The objective is to review recent research on garcinol’s anticancer properties, its mechanisms of action, and safety aspects. Garcinol exhibits anticancer effects in esophageal, gastric, colorectal, pancreatic, and liver cancers by inhibiting metastasis, inducing apoptosis, and targeting key molecular pathways in cancer progression. Nanotechnology is explored as a means to enhance garcinol delivery and efficacy. Safety assessments suggest a promising toxicity profile. Garcinol shows significant potential as a natural therapeutic agent for gastrointestinal cancers, and future research is needed on optimizing its delivery, exploring synergistic combinations, and conducting clinical trials to validate its efficacy and safety for clinical applications.  \nKeywords Garcinol · Gastrointestinal cancers · Pharmacokinetics · Apoptosis · Targeted therapy  \nIntroduction  \nCancers are characterized by aberrant cell proliferation that can infiltrate or spread to other bodily regions. Cancer continues to rank among the world’s most terrible diseases, even with ongoing improvements in diagnostic and treatment techniques (Cao et al. 2021) . Currently, which  \n􀀍 Shafiul Haque [shafiul.haque@hotmail.com](shafiul.haque@hotmail.com)  \n􀀍 Petr Slama[petr.slama@mendelu.cz](petr.slama@mendelu.cz)  \n1 Department of Chemistry, Indian Institute of Technology, Delhi, India  \n2 Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand 248002, India  \n3 Amity Institute of Environmental Toxicology Safety and Management, Amity University, Noida, U.P, India  \n4 Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala 134007, Haryana, India  \ntherapeutic methods are used depends on the type and stage of the malignancy. Among the various treatment options include chemotherapy, radiation therapy, targeted therapy, and surgery (Kaur et al. 2023) . According to projections, there will be approximately 26 million additional cases of cancer by 2030. As per 2018 report, there were 3.4 million associated fatalities and an anticipated 4.8 million  \n5 University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali 140413, India  \n6 Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan  \n45142, Saudi Arabia  \n7 Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University),  \n133207 Mullana, Ambala, India  \n8 Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut 11022801, Lebanon  \n9 Laboratory of Animal Immunology and Biotechnology, Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, 61300 Brno, Czech Republic  \nnew cases of gastrointestinal (GI) malignancies worldwide (Wang et al. 2024) . In the world, 1 in 4 cancer diagnoses and 1 in 3 cancer-related fatalities are caused by gastrointestinal (GI) cancers. Numerou","cbCailgT4x0ptmSd","https://ap.wps.com/l/cbCailgT4x0ptmSd","pdf",1436957,11,"English","# Abstract\n# Introduction\n## Overview of gastrointestinal cancer burden\n## Current treatment approaches and limitations\n## Natural phytochemicals and garcinol as a candidate","[{\"question\":\"What is garcinol and why is it considered for gastrointestinal cancer prevention?\",\"answer\":\"Garcinol is a polyisoprenylated benzophenone naturally present in Garcinia species. The review discusses its potential anticancer effects against multiple gastrointestinal malignancies through multiple biological mechanisms.\"},{\"question\":\"How does garcinol exert anticancer effects according to the review?\",\"answer\":\"The review reports that garcinol can inhibit metastasis, induce apoptosis, and affect key molecular pathways involved in cancer progression, including effects observed in several GI cancer types.\"},{\"question\":\"What role does nanotechnology play for garcinol in this review?\",\"answer\":\"Nanotechnology is explored as a strategy to enhance garcinol delivery and improve efficacy, addressing therapeutic delivery challenges for clinical application.\"}]","Garcinol in gastrointestinal cancer prevention: recent advances and future prospects | PDF",1789991230,28]