[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436082-105":59,"doc-detail-436082-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ganoderma-lucidum-spore-oil-synergistically-enhances-the-function-of-cyclophosphamide-in-the-prevention-of-breast-cancer-metastasis","Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis","","Background: Ganoderma lucidum (G. lucidum) is a traditional Chinese herbal medicine with potential as an alternative adjuvant therapy, yet the mechanisms and benefits in cancer treatment remain unclear. Methods: G. lucidum spore oil (GanoOil) was used to evaluate mechanisms and adjuvant effects together with cyclophosphamide (CTX) for preventing breast cancer metastasis. Results: GanoOil increased CD8+ T cells and IL-6 in mouse blood and enhanced splenic natural killer activity, while GanoOil+CTX suppressed lung metastasis, reduced CTX weight loss, and showed no significant in vitro or in vivo toxicity. Conclusion: GanoOil safely boosts immune activity and synergizes with CTX to inhibit metastasis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ganoderma-lucidum-spore-oil-synergistically-enhances-the-function-of-cyclophosphamide-in-the-prevention-of-breast-cancer-metastasis/436082/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ganoderma-lucidum-spore-oil-synergistically-enhances-the-function-of-cyclophosphamide-in-the-prevention-of-breast-cancer-metastasis/436082.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main therapeutic goal of combining GanoOil with cyclophosphamide (CTX)?","Question",{"text":112,"@type":113},"To synergistically prevent breast cancer metastasis, particularly lung metastasis, by combining GanoOil’s immune-enhancing effects with CTX’s anticancer activity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What immune changes were observed after oral GanoOil administration?",{"text":117,"@type":113},"Oral GanoOil increased CD8+ T cell populations and IL-6 cytokine levels in mouse blood and enhanced natural killer cell activity in the spleen.",{"name":119,"@type":110,"acceptedAnswer":120},"How did the combination of GanoOil and CTX affect metastasis and side effects in mice?",{"text":121,"@type":113},"GanoOil plus CTX suppressed lung metastasis of circulating breast cancer cells, alleviated CTX-induced weight loss, and reduced lung and spleen weight ratios relative to body weight.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436082,1791506501,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J Chin MedAssoc  \nOriginal article  \nGanoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis  \nShu Liana, Wulin Lib, Chunlian Zhonga, Ye Lic, Changhui Wuc, Kun Zhangc, Jiangfei Lina, Weiyu Wanga,d, Vladimir Katanaeve, Xiaodong Xiea,* , Lee Jiaa,b,*  \naFujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China; bInstitute of Chemisty, Fuzhou University, Fuzhou, Fujian, China; cFujian Xianzhilou Biological and Technology Co., Ltd., Fuzhou, Fujian, China; dCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China; eFaculty of Medicine, Department of Cell Physiology and Metabolism, Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland  \nAbstract  \nBackground: Ganoderma lucidum (G. lucidum) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients. However, the mechanisms and adjuvant therapeutic effects of G. lucidum in cancer treatment remain unclear.  \nMethods: In this work, G. lucidum spore oil (GanoOil), a newly developed oily G. lucidum spore extract was used to investigate the mechanisms and adjuvant therapeutic effects of GanoOil in conjunction with the chemotherapeutic drug cyclophosphamide (CTX) for preventing breast cancer metastasis.  \nResults: In the model of lung metastasis, orally administered GanoOil increased the population of CD8+ T cells and interleukin (IL)-6 cytokine levels in mouse blood, whereas also enhancing the activity of natural killer cells in the spleen. Furthermore, the combination of GanoOil and CTX effectively suppressed the lung metastasis of circulating breast cancer cells, alleviated CTX-induced weight loss, and reduced the ratio of lung and spleen weight to body weight in mice. Moreover, high concentrations of GanoOil exhibited no significant toxicity or side effects in both in vitro and in vivo experiments.  \nConclusion: In conclusion, GanoOil is a safe drug that can enhance immune activity in mice to achieve therapeutic effects on cancer, and can also synergistically inhibit tumor metastasis with CTX.  \nKeywords: Cyclophosphamide; IL-6; Natural killer cells; Spleen; Spore  \n1. INTRODUCTION  \nBy 2022, it is estimated that there will be 287 850 new cases of breast cancer and 61 350 cancer-related deaths attributed to breast cancer, making it the cancer with the highest incidence rate and the second-highest mortality rate.1 Distant metastases account for most cancer-related deaths in patients with cancer.2 Breast cancer exhibits a distinct metastatic pattern, commonly involving the bones, liver, lungs, and brain.3 The metastasis of cancers, including breast cancer, is a serious problem in clinical tumor therapy. The traditional treatments for breast cancer and its metastases include surgery, chemotherapy, and radiotherapy. These treatments are associated with many adverse effects and  \n* Address correspondence. Dr. Lee Jia and Dr. Xiaodong Xie, Fujian-TaiwanHongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China. E-mail address:  \n[cmapcjia1234@163.com](cmapcjia1234@163.com) (L. Jia); [fantasyxiaodong@163.com](fantasyxiaodong@163.com) (X. Xie).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2024) 87: 305-313.  \nReceived August 21, 2023; accepted November 3, 2023. doi: 10. 1097/JCMA.0000000000001038  \nCopyright © 2023, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/lic","cbCaipFIFqXAPkI7","https://ap.wps.com/l/cbCaipFIFqXAPkI7","pdf",1299559,"English","# Abstract\n# 1. INTRODUCTION\n## Breast cancer burden and metastasis\n## Current therapies and limitations\n## Ganoderma lucidum and GanoOil background","[{\"question\":\"What is the main therapeutic goal of combining GanoOil with cyclophosphamide (CTX)?\",\"answer\":\"To synergistically prevent breast cancer metastasis, particularly lung metastasis, by combining GanoOil’s immune-enhancing effects with CTX’s anticancer activity.\"},{\"question\":\"What immune changes were observed after oral GanoOil administration?\",\"answer\":\"Oral GanoOil increased CD8+ T cell populations and IL-6 cytokine levels in mouse blood and enhanced natural killer cell activity in the spleen.\"},{\"question\":\"How did the combination of GanoOil and CTX affect metastasis and side effects in mice?\",\"answer\":\"GanoOil plus CTX suppressed lung metastasis of circulating breast cancer cells, alleviated CTX-induced weight loss, and reduced lung and spleen weight ratios relative to body weight.\"}]","Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis | PDF",1790676697,23]