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A prospective study evaluated 37 patients (69 eyes) with peri-chiasmatic or chiasmatic brain tumors undergoing surgical decompression between February 2019 and June 2020, with six-month postoperative follow-up and statistical testing at P \u003C 0.05.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ganglion-cell-complex-and-retinal-nerve-fiber-layer-thickness-in-predicting-visual-outcome-in-brain-tumors-after-surgery-original-article-prospective-study/435084/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ganglion-cell-complex-and-retinal-nerve-fiber-layer-thickness-in-predicting-visual-outcome-in-brain-tumors-after-surgery-original-article-prospective-study/435084.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study aiming to determine?","Question",{"text":112,"@type":113},"The study aimed to determine the proportion of eyes with RNFL and GCC thinning and their association with visual parameters in brain-tumor patients undergoing surgery.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Who were the study participants and what was the follow-up duration?",{"text":117,"@type":113},"The prospective study included 37 patients (69 eyes) with peri-chiasmatic or chiasmatic brain tumors undergoing surgical decompression, with a six-month postoperative follow-up.",{"name":119,"@type":110,"acceptedAnswer":120},"How did OCT measurements relate to visual outcomes?",{"text":121,"@type":113},"RNFL and GCC thickness measurements using OCT were linked to visual recovery after chiasmal compression, with greater GCC thinning associated with worse visual impairment and ROC-derived cut-off values for preventing blindness.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},435084,1791095413,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","| W | J | E | M | World Journal of\u003Cbr>Experimental Medicine |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Exp Med 2025 December 20; 15(4): 108702  \nDOI: 10.5493/wjem.v15.i4.108702 ISSN 2220-315x (online)  \nORIGINAL ARTICLE  \nProspective Study  \nGanglion cell complex and retinal nerve fiber layer thickness in predicting visual outcome in brain tumors after surgery  \nSucheta Parija, Koyel Chakraborty, Rabi Narayan Sahu, Bhagabat Nayak, Ravikumar Subraya Rathod  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade C  \nNovelty: Grade B, Grade B  \nCreativity or Innovation: Grade B, Grade B  \nScientific Significance: Grade B, Grade C  \nP-Reviewer: O'Grady P, MD, Associate Professor, FACS, FRSC, Ireland; Zhu CR, MD, PhD, Chief Physician, Professor, China  \nReceived: April 22, 2025  \nRevised: June 10, 2025  \nAccepted: September 16, 2025  \nPublished online: December 20, 2025  \nProcessing time: 241 Days and 14.2 Hours  \nSucheta Parija, Bhagabat Nayak, Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India  \nKoyel Chakraborty, Department of Ophthalmology, All India Institute of Medical Sciences Kalyani, Kolkota 741245, West Bengal, India  \nRabi Narayan Sahu, Department of Neurosurgery, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India  \nRavikumar Subraya Rathod, Department of Community Medicine, Government Medical College  \nand Hospital, Chandigarh 160030, Chandīgarh, India Co-first authors: Sucheta Parija and Koyel Chakraborty.  \nCorresponding author: Sucheta Parija, Head, Professor, Department of Ophthalmology, All India Institute of Medical Sciences, Patrapada, Bhubaneshwar 751019, Odisha, India.  \n[ophthal_sucheta@aiimsbhubaneswar.edu.in](ophthal_sucheta@aiimsbhubaneswar.edu.in)  \nAbstract  \nBACKGROUND  \nAnterior visual pathway lesions can cause severe visual loss. Optical coherence tomography (OCT) can detect ganglion cell complex (GCC) thinning, even with normal retinal nerve fiber layer (RNFL) thickness and subtle visual field changes.  \nAIM  \nTo determine the proportion of eyes with RNFL and GCC thinning and their association with visual parameters in patients with brain tumors undergoing surgery.  \nMETHODS  \nA prospective study was conducted on 37 patients (69 eyes) with peri-chiasmatic and chiasmatic brain tumors undergoing surgical decompression between February 2019 and June 2020 at a tertiary care institute. A comprehensive neuroophthalmological work-up, demographic and clinical profile documentation, and six-month postoperative follow-up weredone. Statistical analysis was significant at P \u003C 0.05.  \nRESULTS  \nMean age was 35.14 ± 11.98 years. The best and worst visual outcomes were associated with the craniopharyngioma and meningioma groups, respectively (P =  \n WJEM  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 20, 2025  Volume 15  Issue 4   \nParija S et al. GCC thickness predictor vision brain tumors  \n0.008) . There was an increase in the proportion of eyes with RNFL damage in the inferior quadrant (P = 0.02) . Maximum GCC thickness thinning was associated with severe visual impairment. The odds of having blindness in eyes with RNFL (inferior) and GCC loss were 0.96 (P = 0.003) and 0.95 (P = 0.03), respectively. GCC thickness showed a clinically positive correlation with visual acuity (r = -0.48, P \u003C 0.001) and field defect (r = -0.27, P = 0.04) at six months postoperatively. The preoperative GCC thickness and the final postoperative visual outcome were plotted in an empirical ROC curve with area under the curve = 0.754. The cut-off value of RNFL (inferior) and GCC, beyond which blindness could be prevented, was 73 µm and 58 µm, respectively.  \nCONCLUSION  \nIn chias","cbCaidoO9zylvHsB","https://ap.wps.com/l/cbCaidoO9zylvHsB","pdf",3716420,13,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n## Key Words","[{\"question\":\"What was the study aiming to determine?\",\"answer\":\"The study aimed to determine the proportion of eyes with RNFL and GCC thinning and their association with visual parameters in brain-tumor patients undergoing surgery.\"},{\"question\":\"Who were the study participants and what was the follow-up duration?\",\"answer\":\"The prospective study included 37 patients (69 eyes) with peri-chiasmatic or chiasmatic brain tumors undergoing surgical decompression, with a six-month postoperative follow-up.\"},{\"question\":\"How did OCT measurements relate to visual outcomes?\",\"answer\":\"RNFL and GCC thickness measurements using OCT were linked to visual recovery after chiasmal compression, with greater GCC thinning associated with worse visual impairment and ROC-derived cut-off values for preventing blindness.\"}]","Ganglion cell complex and retinal nerve fiber layer thickness in predicting visual outcome in brain tumors after surgery - Original Article - Prospective Study | PDF",1790671798,33]