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This study evaluated whether gamified tablet-based cognitive tests targeting executive function (Gridshot), working memory (Capacity), and spatial tracking (Multitracker) would show reduced performance after moderate normobaric hypoxic exposure compared with normoxia. Twenty-one healthy adults completed practice sessions and then performed timed game rounds at baseline and after exposure, while oxygenation was monitored with forehead pulse oximetry and data were analyzed with ANCOVA.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gamified-assessment-of-cognitive-performance-during-moderate-hypoxia/449389/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gamified-assessment-of-cognitive-performance-during-moderate-hypoxia/449389.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main goal of the study?","Question",{"text":112,"@type":113},"To test whether performance on gamified cognitive tests across executive function, working memory, and spatial tracking decreases during moderate normobaric hypoxia compared with normoxia.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants tested and when were measurements taken?",{"text":117,"@type":113},"After three days of practice, twenty-one healthy adults completed five 1-minute rounds of Gridshot, Capacity, and Multitracker at baseline and at 60 and 90 minutes after exposure to hypoxia or normoxia in a single-blind randomized format.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings about cognitive test performance under hypoxia?",{"text":121,"@type":113},"Oxygen saturation was lower during hypoxia, but no condition-by-time interaction effects were found for the gamified cognitive tests. Overall, performance effects were not consistently altered by acute moderate hypoxic exposure.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},449389,1790790624,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","PLOS ONE  \nOPEN ACCESS  \nCitation: Keeler JM, Tourula E, Hite MJ, Listman JB, Heeger DJ, Port NL, et al. (2023) Gamified assessment of cognitive performance during moderate hypoxia. PLoS ONE 18(7): e0288201 .  \n[https://doi.org/10.1371/journal.pone.0288201](https://doi.org/10.1371/journal.pone.0288201)  \n[Editor:](Editor: Tadej Debevec)[ Tadej Debevec](Editor: Tadej Debevec), [University of Ljubljana](University of Ljubljana), SLOVENIA  \nReceived: March 8, 2023  \nAccepted: June 21, 2023  \nPublished: July 17, 2023  \nCopyright: © 2023 Keeler et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: Deidentified environmental, physiological, and composite score data is available via the Indiana University public repository (IU Scholar Works) at the following url:  \n[https://hdl.handle.net/2022/29274](https://hdl.handle.net/2022/29274. The)[. The](https://hdl.handle.net/2022/29274. The) raw data from Aim Lab tasks are not readily available because they are proprietary and are owned by Statespace Labs. Requests to access the datasets can be directed to [research@statespacelabs.com](research@statespacelabs.com), [info@statespacelabs.com](info@statespacelabs.com), or Dr. David Heeger at [david@statespacelabs.com](david@statespacelabs.com).  \nRESEARCH ARTICLE  \nGamified assessment of cognitive performance during moderate hypoxia  \nJason M. Keeler1, Erica Tourula1, M. Jo Hite1, Jennifer B. Listman2, David J. Heeger2, Nicholas L. Port3, Zachary J. Schlader1 *  \n1 Department of Kinesiology, H. H. Morris Human Performance Laboratories, School of Public Health, Indiana University, Bloomington, Indiana, United States of America, 2 Statespace Labs, Inc. New York, New York, United States of America, 3 School of Optometry, Indiana University, Bloomington, Indiana, United States of America  \n* [zschlade@iu.edu](zschlade@iu.edu)  \nAbstract  \nIntroduction  \nThere is a need for rapid and objective assessment tools to identify people at risk of impaired cognitive function during hypoxia.  \nPurpose  \nTo test the hypotheses that performance on gamified cognitive tests examining the cognitive domains of executive function (Gridshot), working memory (Capacity) and spatial tracking (Multitracker) will be reduced during normobaric exposure to moderate normobaric hypoxia.  \nMethods  \nFollowing three consecutive days of practice, twenty-one healthy adults (27 ± 5 y, 9 females) completed five 1-min rounds of the tablet-based games Gridshot, Capacity, and Multitracker (Statespace Labs, Inc.) at Baseline and 60 and 90 min after exposure to 14.0 ± 0 .2%(hypoxia) and 20.6 ± 0 .3%(normoxia) oxygen. Both conditions were completed on the same day and were administered in a single-blind, block randomized manner. Arterial oxyhemoglobin saturation was estimated via forehead pulse oximetry (SpO2) . Data were analyzed using ANCOVA with a covariate of Baseline.  \nResults  \nCompared to normoxia (98 ± 1%), SpO2 was lower (p \u003C 0.001) at 60 (91 ± 3%) and 90 (91 ± 2%) min of hypoxia. No condition x time interaction effects were identified for any gamified cognitive tests (p 􀀕 0 .32) . A main effect of condition was identified for Capacity (p = 0.05) and Multitracker (p = 0.04), but not Gridshot (p = 0.33) . Post hoc analyses of the composite scores for both Capacity (p = 0. 11) and Multitracker (p = 0.73) demonstrated no difference between conditions.  \nFunding: ZJS and NLP received funding from Statespace Laboratories Inc. for this work.  \nStatespace Labs, Inc.’s URL is [https://aimlabs](https://aimlabs). com. The funder had the following involvement with the study: The funder helped in study design, manuscript preparation, and the funder developed and maintains the commercial software and database for Brain Lab, which served as a data collection instrument for ","cbCaifJ81BO9iZOC","https://ap.wps.com/l/cbCaifJ81BO9iZOC","pdf",1681982,18,"English","# Abstract\n## Introduction\n## Purpose\n## Methods\n## Results\n## Conclusion\n## Funding and competing interests","[{\"question\":\"What was the main goal of the study?\",\"answer\":\"To test whether performance on gamified cognitive tests across executive function, working memory, and spatial tracking decreases during moderate normobaric hypoxia compared with normoxia.\"},{\"question\":\"How were participants tested and when were measurements taken?\",\"answer\":\"After three days of practice, twenty-one healthy adults completed five 1-minute rounds of Gridshot, Capacity, and Multitracker at baseline and at 60 and 90 minutes after exposure to hypoxia or normoxia in a single-blind randomized format.\"},{\"question\":\"What were the key findings about cognitive test performance under hypoxia?\",\"answer\":\"Oxygen saturation was lower during hypoxia, but no condition-by-time interaction effects were found for the gamified cognitive tests. Overall, performance effects were not consistently altered by acute moderate hypoxic exposure.\"}]","Gamified assessment of cognitive performance during moderate hypoxia | PDF",1790730090,45]