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Institutional Review Board approval was obtained (IRB No. 12511).",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/gallium-68-citrate-petct-for-diagnosis-and-treatment-response-assessment-of-infections-prospective-study/445199/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/gallium-68-citrate-petct-for-diagnosis-and-treatment-response-assessment-of-infections-prospective-study/445199.png","ImageObject",300,407,{"name":42,"@type":43},"acoobca","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main objective of the study?","Question",{"text":63,"@type":64},"To assess skeletal and soft tissue infections before or after treatment and evaluate treatment response in Ga-68 citrate PET/CT positive patients.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Who were the participants and what were the main inclusion/exclusion criteria?",{"text":68,"@type":64},"Forty-three patients clinically suspected of infection underwent Ga-68 citrate PET/CT. Pregnancy and lactation were excluded.",{"name":70,"@type":61,"acceptedAnswer":71},"How was imaging interpretation performed?",{"text":72,"@type":64},"PET/CT interpretation relied on visual comparison of Ga-68 citrate uptake in the region of interest with the normal side/adjacent soft tissue/blood pool, with maximum standardized uptake value also analyzed retrospectively.",{"name":74,"@type":61,"acceptedAnswer":75},"What overall conclusion does the study reach?",{"text":76,"@type":64},"Ga-68 citrate PET/CT is a promising tool for assessing bone and soft tissue infections before or after treatment.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},445199,1790957462,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,114,119,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},7,40,"healthcare",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},"Religion & Spirituality",20,"religion-spirituality",{"id":121,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":121,"slug":125},"World Cup","world-cup",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":127,"slug":129},10,"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":101,"slug":133},19,"General","general",{"code":4,"msg":86,"data":135},{"doc_id":83,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":143,"language":144,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":12,"update_tm":148,"read_time":149,"preview_page_count":4},3985747870733,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Article published online: 2025-04-01  \nOriginal Article 305  \nGallium-68 Citrate PET/CT for Diagnosis and Treatment Response Assessment of Infections—Prospective Study  \nHanna Elizabeth Johnson 1 Saumya Sara Sunny 1 David Mathew 1 Regi Oommen 1 Nylla Shanthly 1 Priscilla Rupali2 Regi Thomas3,4 Rajan Sundaresan4 Sumant Samuel5 Anil Oommen5 Venkatesh Krishnan6 Julie Hephzibah 1 Reka K.7  \n1 Department of Nuclear Medicine, Christian Medical College and Hospital, Christian Medical College, Vellore, Tamil Nadu, India  \n2 Department of Infectious Diseases, Christian Medical College and Hospital, Vellore, Tamil Nadu, India  \n3 Department of Otorhinolaryngology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India  \n4 Department of ENT-1, Head & Neck Skull Base Surgery Unit, Christian Medical College, Vellore, Tamil Nadu, India  \n5 Department of Orthopedics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India  \nWorld J Nuclear Med 2025;24:305–318.  \nAddress for correspondence Julie Hephzibah, DNB Nuclear Medicine, Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India  \n(e-mails: [drjulsan@cmcvellore.ac.in](drjulsan@cmcvellore.ac.in); [drjulsan@gmail.com](drjulsan@gmail.com)).  \n6 Department of Spinal Disorder Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu, India  \n7 Department of Biostatistics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India  \nAbstract  \nKeywords  \n► Ga-68 citrate  \n► imaging  \n► infection  \n► osteomyelitis  \n► PET/CT  \nObjective This article aims to assess the presence of skeletal and soft tissue infections before or after treatment and to assess treatment response in Ga-68 citrate positron emission tomography/computed tomography (PET/CT) scan positive patients. Materials and Methods A prospective study was conducted for 43 patients. The eligibility criteria included those patients clinically suspected of infections who underwent a Ga-68 citrate PET/CT. Exclusion criteria were pregnancy and lactation. Patients with suspicion of infection or treatment failure underwent a Ga-68 citrate PET/CT between January 2020 and November 2021 . Among these, eight patients underwent a follow-up scan posttreatment to assess their treatment response. The Institutional Review Board (IRB No.12511) approved the study.  \nResults Forty-three patients underwent a diagnostic Ga-68 citrate PET/CT scan. The scan interpretation was based on visual comparison of uptake of Ga-68 citrate in the region of interest, which was compared with the normal side/adjacent soft tissue/blood pool. Thesemiquantitative parameter maximum standardized uptake value was retrospectively analyzed as well. PET/CT findings were correlated with tissue diagnosis, clinical symptoms, biochemical parameters like C-reactive protein (CRP), erythrocyte sedimentation rate, and total leukocyte count, and other imaging modalities with a statistically significant association with CRP(p ¼ 0.001). Tissue diagnosis was considered the gold standard and out of the 43patients included in the study, 27hada tissue diagnosis. Sensitivity, specificity, negative predictive value, positive predictive value, and accuracy were calculated at 100, 87.5, 100, 95, and 96.3%, respectively.  \nConclusion Ga-68 citrate is a promising tool to assess the presence of bone and soft tissue infections before or after treatment.  \narticle published online April 1, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1807256 . ISSN 1450-1147.  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited.([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Medical and Scientific Publishers Pvt. Ltd. , A-12, 2nd Floor, Sector 2, Noid","cbCaikrZpdzKMyNp","https://ap.wps.com/l/cbCaikrZpdzKMyNp","pdf",5717505,14,"English","# Abstract\n## Objective\n## Materials and Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the main objective of the study?\",\"answer\":\"To assess skeletal and soft tissue infections before or after treatment and evaluate treatment response in Ga-68 citrate PET/CT positive patients.\"},{\"question\":\"Who were the participants and what were the main inclusion/exclusion criteria?\",\"answer\":\"Forty-three patients clinically suspected of infection underwent Ga-68 citrate PET/CT. Pregnancy and lactation were excluded.\"},{\"question\":\"How was imaging interpretation performed?\",\"answer\":\"PET/CT interpretation relied on visual comparison of Ga-68 citrate uptake in the region of interest with the normal side/adjacent soft tissue/blood pool, with maximum standardized uptake value also analyzed retrospectively.\"},{\"question\":\"What overall conclusion does the study reach?\",\"answer\":\"Ga-68 citrate PET/CT is a promising tool for assessing bone and soft tissue infections before or after treatment.\"}]","Gallium-68 Citrate PET/CT for Diagnosis and Treatment Response Assessment of Infections - Prospective Study | PDF",1790710625,35]