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This study tests whether F. nucleatum drives CRC onset and development by altering intestinal butyric acid derived from microbiome fermentation. In BALB/c mice, oral F. nucleatum shifts butyrate-producing bacteria and butyric acid levels; in DLD-1 and HCT116 cells sodium butyrate impairs mitochondrial function and activates AMPK, suppressing proliferation, with AMPK dependence confirmed by siRNA.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fusobacterium-nucleatum-induced-imbalance-in-microbiome-derived-butyric-acid-levels-promotes-the-occurrence-and-development-of-colorectal-cancer/332014/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fusobacterium-nucleatum-induced-imbalance-in-microbiome-derived-butyric-acid-levels-promotes-the-occurrence-and-development-of-colorectal-cancer/332014.png","ImageObject",300,407,{"name":92,"@type":93},"Ava Thompson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the study investigating about Fusobacterium nucleatum and colorectal cancer?","Question",{"text":113,"@type":114},"It investigates whether Fusobacterium nucleatum promotes colorectal cancer occurrence and development by impacting intestinal metabolite butyric acid.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What changes occur in mice after oral administration of Fusobacterium nucleatum?",{"text":118,"@type":114},"Fusobacterium nucleatum colonization decreases butyrate-producing bacteria, leading to altered butyric acid levels.",{"name":120,"@type":111,"acceptedAnswer":121},"How does sodium butyrate affect colorectal cancer cells in the study?",{"text":122,"@type":114},"Sodium butyrate impairs mitochondrial morphology and membrane potential, modulates ATP and reactive oxygen species, triggers AMPK signaling, blocks the cell cycle, and reduces proliferation.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332014,1790258817,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},1649267921044,"https://us-avatar.wpscdn.com/avatar/1800007509477c92dfb?_k=1786009248482753345","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2024 April 14; 30(14): 2018-2037  \nDOI: 10.3748/wjg.v30.i14.2018 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nBasic Study  \nFusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer  \nQi-Long Wu, Xiao-Ting Fang, Xin-Xin Wan, Qing-Yong Ding, Yan-Jun Zhang, Ling Ji, Yong-Liang Lou, Xiang Li  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B, B  \nGrade C (Good): 0  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Jordan P, Portugal  \nReceived: October 31, 2023  \nPeer-review started: October 31, 2023  \nFirst decision: December 15, 2023  \nRevised: January 11, 2024  \nAccepted: February 29, 2024  \nArticle in press: February 29, 2024  \nPublished online: April 14, 2024  \nQi-Long Wu, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou 325035, Zhejiang Province, China  \nXiao-Ting Fang, Department of Health Inspection and Quarantine, School of Laboratory Medicine and Life Sciences, Wenzhou 325035, Zhejiang Province, China  \nXin-Xin Wan, Qing-Yong Ding, Yan-Jun Zhang, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Medical Genetics, Ministry of Education, Wenzhou 325035, Zhejiang Province, China  \nLing Ji, Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China  \nYong-Liang Lou, School of Laboratory Medicine and Life Sciences, Institute of One Health, Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Medical Genetics, Ministry of Education, Wenzhou 325035, Zhejiang Province, China  \nXiang Li, Department of Health Inspection and Quarantine, School of Laboratory Medicine and Life Sciences, Institute of One Health, Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Medical Genetics, Ministry of Education, Wenzhou 325035, Zhejiang Province, China  \nCorresponding author: Xiang Li, PhD, Associate Professor, Deputy Director, Postdoc, Department of Health Inspection and Quarantine, School of Laboratory Medicine and Life Sciences, Institute of One Health, Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Medical Genetics, Ministry of Education, No. 1 Qiuzhen Road, Wenzhou 325035, Zhejiang Province, [China.](China. yhx2008@163.com)[ yhx2008@163.com](China. yhx2008@163.com)  \nAbstract  \nBACKGROUND  \nColorectal cancer (CRC) ranks among the most prevalent malignant tumors globally. Recent reports suggest that Fusobacterium nucleatum (F. nucleatum) contributes to the initiation, progression, and prognosis of CRC. Butyrate, a shortchain fatty acid derived from the bacterial fermentation of soluble dietary fiber, is  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 2018 April 14, 2024  Volume 30  Issue 14   \nWu QL et al. F. nucleatum promotes CRC development  \nknown to inhibit various cancers. This study is designed to explore whether F. nucleatum influences the onset and progression of CRC by impacting the intestinal metabolite butyric acid.  \nAIM  \nTo investigate the mechanism by which F. nucleatum affects CRC occurrence and development.  \nMETHODS  \nAlterations in the gut microbiota of BALB/c mice were observed following the oral administration of F. nucleatum. Additionally, DLD-1 and HCT116 cell lines were exposed to sodium butyrate (NaB) and F. nucleatum in vitro to examine the effects on proliferative proteins and mitochondrial function.  \nRESULTS  \nOur re","cbCairgpNRMPEFdn","https://ap.wps.com/l/cbCairgpNRMPEFdn","pdf",8771998,21,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip\n# Keywords","[{\"question\":\"What is the study investigating about Fusobacterium nucleatum and colorectal cancer?\",\"answer\":\"It investigates whether Fusobacterium nucleatum promotes colorectal cancer occurrence and development by impacting intestinal metabolite butyric acid.\"},{\"question\":\"What changes occur in mice after oral administration of Fusobacterium nucleatum?\",\"answer\":\"Fusobacterium nucleatum colonization decreases butyrate-producing bacteria, leading to altered butyric acid levels.\"},{\"question\":\"How does sodium butyrate affect colorectal cancer cells in the study?\",\"answer\":\"Sodium butyrate impairs mitochondrial morphology and membrane potential, modulates ATP and reactive oxygen species, triggers AMPK signaling, blocks the cell cycle, and reduces proliferation.\"}]","Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer | PDF",1789996310,53]