[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331831-105":59,"doc-detail-331831-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","fusobacterium-nucleatum-in-tumors-from-tumorigenesis-to-tumor-metastasis-and-tumor-resistance","Fusobacterium nucleatum in tumors - from tumorigenesis to tumor metastasis and tumor resistance","","Fusobacterium nucleatum, an anaerobic Gram-negative bacterium that primarily inhabits the oral cavity, is increasingly recognized for roles in cancer progression and patient outcomes. Mechanistic links are well established for colorectal cancer, but a broader synthesis covering other tumor types has been lacking. This review expands coverage to cancers including oral, pancreatic, esophageal, breast, and gastric malignancies, emphasizing colonization-driven tumorigenesis, metastasis promotion, therapeutic impairment, and the value of F. nucleatum as a biomarker and therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fusobacterium-nucleatum-in-tumors-from-tumorigenesis-to-tumor-metastasis-and-tumor-resistance/331831/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fusobacterium-nucleatum-in-tumors-from-tumorigenesis-to-tumor-metastasis-and-tumor-resistance/331831.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the role of Fusobacterium nucleatum in tumor development?","Question",{"text":112,"@type":113},"It is discussed as a contributor to tumorigenesis and metastasis across multiple cancer types through several mechanisms, including immune modulation, virulence factors, microRNA-related effects, metabolite interactions, DNA damage, and epithelial-mesenchymal transition.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cancers beyond colorectal cancer are covered in the review?",{"text":117,"@type":113},"The review highlights malignancies associated with Fusobacterium nucleatum such as oral, pancreatic, esophageal, breast, and gastric cancers.",{"name":119,"@type":110,"acceptedAnswer":120},"How might Fusobacterium nucleatum affect cancer therapy outcomes?",{"text":121,"@type":113},"The text notes potential adverse impacts on cancer treatment, especially regarding therapy response in contexts including immunotherapy and chemotherapy, and provides an example linking high abundance in esophageal squamous cell carcinoma with poorer responses to neoadjuvant chemotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331831,1790126559,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","REVIEW  \nFusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance  \nChun Yea, Xiao Liua, Zilun Liua, Chuxuan Pana, Xiaowei Zhanga, Zhanyi Zhaoa, and Haitao Sun a,b  \naClinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China; bDepartment of Laboratory Medicine, Central People’s Hospital of Ji’an, Shanghai East Hospital of Ji’an, Ji’an, China  \nABSTRACT  \nFusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. While extensive research has revealed mechanistic links between Fusobacterium nucleatum and colorectal cancer, a comprehensive review spanning its presence and metastatic implications in cancers beyond colorectal origin is conspicuously absent. This paper broadens our perspective from colorectal cancer to various malignancies associated with Fusobacterium nucleatum, including oral, pancreatic, esophageal, breast, and gastric cancers. Our central focus is to unravel the mechanisms governing Fusobacterium nucleatum colonization, initiation, and promotion of metastasis across diverse cancer types. Additionally, we explore Fusobacterium nucleatum‘s adverse impacts on cancer therapies, particularly within the domains of immunotherapy and chemotherapy. Furthermore, this paper underscores the clinical research significance of Fusobacterium nucleatum as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment.  \nARTICLE HISTORY  \nReceived 5 November 2023 Revised 29 December 2023 Accepted 13 January 2024  \nKEYWORDS  \nFusobacterium nucleatum; tumorigenesis; tumor metastasis; tumor resistance; mechanism  \n1. Introduction  \nFusobacterium nucleatum (F. nucleatum), a member of the genus Fusobacterium, is a gram-negative, non-spore-forming, obligate anaerobic bacterium with a slender shape and fusiform ends.1 Initially considered a commensal bacterium primarily inhabiting the oral cavity of humans and animals, its frequent isolation during disease activity has led to the recognition of F. nucleatum as an opportunistic pathogen. Current understanding positions F. nucleatum as a potential contributor to the pathogenesis of several human diseases.1 In disease contexts, including gastrointestinal tumors, breast cancer, and other malignancies, F. nucleatum is emerging as a prevalent species outside the oral environment (Table 1).11 Furthermore, mounting evidence implicates F. nucleatum in the development of various gastrointestinal tumors, breast cancer, and other  \nmalignancies (Table 1). While earlier research has firmly established F. nucleatum as a catalyst for the progression and severity of colorectal cancer (CRC), recent investigations have unveiled its presence in a spectrum of gastrointestinal and extragastrointestinal tumors, often associated with a poor prognosis. 12 F. nucleatum engages in tumorigenesis and metastasis across diverse cancer types through multifaceted mechanisms, including immune response modulation, virulence factors, oncogenic microRNAs, intestinal metabolite interactions, DNA damage, and epithelial-mesenchymal transition.13–15 Additionally, compelling research suggests that F. nucleatum may exert detrimental effects on cancer treatment outcomes.16 For instance, inpatients with esophageal squamous cell carcinoma, a high abundance of F. nucleatum has been linked to adverse responses toneoadjuvant chemotherapy.17  \nCONTACT Haitao Sun  [2009sht@smu.edu.cn](2009sht@smu.edu.cn)  Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510280, China  \n© 2024 The Author(s) . Published with license by T","cbCaipQ56ewxYrKk","https://ap.wps.com/l/cbCaipQ56ewxYrKk","pdf",5563858,"English","# Introduction\n## F. nucleatum as an opportunistic pathogen\n## Links between F. nucleatum and cancer progression","[{\"question\":\"What is the role of Fusobacterium nucleatum in tumor development?\",\"answer\":\"It is discussed as a contributor to tumorigenesis and metastasis across multiple cancer types through several mechanisms, including immune modulation, virulence factors, microRNA-related effects, metabolite interactions, DNA damage, and epithelial-mesenchymal transition.\"},{\"question\":\"Which cancers beyond colorectal cancer are covered in the review?\",\"answer\":\"The review highlights malignancies associated with Fusobacterium nucleatum such as oral, pancreatic, esophageal, breast, and gastric cancers.\"},{\"question\":\"How might Fusobacterium nucleatum affect cancer therapy outcomes?\",\"answer\":\"The text notes potential adverse impacts on cancer treatment, especially regarding therapy response in contexts including immunotherapy and chemotherapy, and provides an example linking high abundance in esophageal squamous cell carcinoma with poorer responses to neoadjuvant chemotherapy.\"}]","Fusobacterium nucleatum in tumors - from tumorigenesis to tumor metastasis and tumor resistance | PDF",1789995391,48]