[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-339840-105":59,"doc-detail-339840-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","functions-and-mechanisms-of-rna-m6a-regulators-in-breast-cancer-review","Functions and mechanisms of RNA m6A regulators in breast cancer - Review","","Breast cancer is a major malignant tumor in women, with rising global incidence. RNA N6-methyladenosine (m6A) is a widespread mRNA methylation that, when abnormally expressed together with its regulatory proteins, can activate or suppress signaling pathways and oncogenes, influencing proliferation, metastasis, and prognosis. Disrupted m6A regulators have been reported in breast cancer and may be reversible, supporting m6A as a potential therapeutic target. This review summarizes functions and mechanisms of m6A regulators, including the dual role of RNA methylation in tumor progression, and discusses how deeper mechanistic analyses can guide target screening and targeted treatment strategies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/functions-and-mechanisms-of-rna-m6a-regulators-in-breast-cancer-review/339840/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/functions-and-mechanisms-of-rna-m6a-regulators-in-breast-cancer-review/339840.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the role of m6A in breast cancer according to the review?","Question",{"text":113,"@type":114},"The review explains that abnormal m6A expression and dysregulated m6A regulatory proteins can activate or inhibit signaling pathways and oncogenes, thereby affecting breast cancer proliferation, metastasis, and prognosis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why are m6A regulators considered potential therapeutic targets for breast cancer?",{"text":118,"@type":114},"The article notes that disorder of m6A regulators exists in breast cancer and can be reversed, and it predicts m6A as a potential therapeutic target. Mechanistic insights are intended to support target screening and targeted treatment strategies.",{"name":120,"@type":111,"acceptedAnswer":121},"How does RNA methylation show a dual role in tumor progression?",{"text":122,"@type":114},"The review discusses that RNA methylation can lead to tumorigenesis, but in some contexts it can also inhibit tumor formation, indicating context-dependent effects during tumor progression.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},339840,1790123779,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","INTERNATIONAL JOURNAL OF ONCOLOGY 65: 86, 2024  \nFunctions and mechanisms of RNA m6A regulators in breast cancer (Review)  \nYIBEI YANG 1,2 , FENG GAO3 , LANQI REN2 , NING REN2 , JUNJIE PAN2 and QIAOPING XU 1  \n1Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,  \nAffiliated Hangzhou First People's Hospital, Cancer Center, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, 2  \nP.R. China; Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310051, P.R. China; 3Department of Urology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310000, P.R. China  \nReceived April 23, 2024; Accepted July 9, 2024  \nDOI: 10.3892/ijo.2024.5674  \nAbstract. Breast cancer (BC) is a major malignant tumor in females and the incidence rate of BC has increased worldwide in recent years. N6‑methyladenosine (m6A) is a methylation modification that occurs extensively in eukaryotic RNA. The abnormal expression of m6A and related regulatory proteins can activate or inhibit certain signal pathways or oncogenes, thus affecting the proliferation, metastasis and prognosis of BC. Numerous studies have shown that m6A regulator disorder exists in BC, and this disorder can be reversed. Therefore, m6A is predicted as a potential therapeutic target for BC. However, the molecular mechanism of m6A RNA methylation regulating the occurrence and development of BC has not been comprehensively elucidated. In this review article, the func‑ tions of various m6A regulators and the specific mechanisms of certain regulators of the progress of BC were summarized. Furthermore, the dual role of RNA methylation in tumor progression was discussed, concluding that RNA methylation can not only lead to tumorigenesis but at times give rise to inhibition of tumor formation. In addition, further compre‑ hensive analysis on mechanisms of m6A regulators in BC is conducive to screening effective potential targets and formu‑ lating targeted treatment strategies, which will provide new methods for the prevention and treatment of BC.  \nCorrespondence to: Dr Qiaoping Xu, Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center, Westlake University School of Medicine, 261 Huan Sha Road, Hangzhou, Zhejiang 310006, P.R. China  \nE‑mail: [xqp1984@126.com](xqp1984@126.com)  \nKey words: breast cancer, N6‑methyladenosine, m6A modification regulator, mechanistic pathways, RNA  \nContents  \n1. Introduction  \n2. BC  \n3. M6A  \n4. M6A and BC  \n5. M6A modification and genomic instability in BC  \n6. M6A modification and therapeutic resistance in BC  \n7. Summary and outlook  \n1. Introduction  \nBreast cancer (BC) is a common malignant tumor and its incidence rate has shown an overall upward trend in the past decade (1) . Despite the progress in both understanding and treating BC, nearly 30% of patients suffer from recurrence or metastasis due to the deficiency of effective treatment or prevention strategies, which is the main reason for BC‑related mortality (2) . The extensively used classification for BC comprises Luminal A, Luminal B, human epidermal growth factor receptor (EGFR) 2 (HER2) overexpression and triple‑negative BC (TNBC) (3) . Studies have indicated that with early diagnosis and timely treatment, the overall survival of nonmetastatic BC and de novo metastatic BC (MBC) has been evidently improved. However, for recurrent MBC and elderly patients, there has been no improvement in decades (4) . Hence, investigating the molecular mechanisms underlying the onset and progression of BC, and enhancing the capacity for monitoring BC treatment efficacy or identifying promising therapeutic targets, are of immense importance for precise diagnosis, efficient stratified management and the develop‑ ment of more refined treatment strat","cbCaim2jvEU50714","https://ap.wps.com/l/cbCaim2jvEU50714","pdf",3276610,15,"English","# 1. Introduction\n# 2. BC\n# 3. M6A\n# 4. M6A and BC\n# 5. M6A modification and genomic instability in BC\n# 6. M6A modification and therapeutic resistance in BC\n# 7. Summary and outlook","[{\"question\":\"What is the role of m6A in breast cancer according to the review?\",\"answer\":\"The review explains that abnormal m6A expression and dysregulated m6A regulatory proteins can activate or inhibit signaling pathways and oncogenes, thereby affecting breast cancer proliferation, metastasis, and prognosis.\"},{\"question\":\"Why are m6A regulators considered potential therapeutic targets for breast cancer?\",\"answer\":\"The article notes that disorder of m6A regulators exists in breast cancer and can be reversed, and it predicts m6A as a potential therapeutic target. Mechanistic insights are intended to support target screening and targeted treatment strategies.\"},{\"question\":\"How does RNA methylation show a dual role in tumor progression?\",\"answer\":\"The review discusses that RNA methylation can lead to tumorigenesis, but in some contexts it can also inhibit tumor formation, indicating context-dependent effects during tumor progression.\"}]","Functions and mechanisms of RNA m6A regulators in breast cancer - Review | PDF",1790032557,38]