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A prospective interventional study evaluated how intra-articular platelet-rich plasma (PRP) influences functional recovery in 30 patients who did not respond to standard conservative therapy. Participants received a single PRP injection, with pain assessed by VAS and function by DASH over 1 week, 1 month, 3 months, and 6 months. Results after 6 months showed marked pain reduction and functional improvement, with better outcomes in younger, non-diabetic patients and those with shorter symptom duration.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/functional-outcome-of-intra-articular-platelet-rich-plasma-in-the-treatment-of-frozen-shoulder/447505/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/functional-outcome-of-intra-articular-platelet-rich-plasma-in-the-treatment-of-frozen-shoulder/447505.png","ImageObject",300,407,{"name":92,"@type":93},"anakgang17","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition does this study focus on, and why is it challenging to treat?","Question",{"text":112,"@type":113},"The study focuses on frozen shoulder (adhesive capsulitis), which is characterized by persistent pain and limited shoulder range of motion. Treatment can be difficult, especially when standard conservative therapies fail.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was platelet-rich plasma (PRP) administered and evaluated in the study?",{"text":117,"@type":113},"Thirty patients received a single intra-articular PRP injection. Pain and functional outcomes were measured using VAS and DASH scores at 1 week, 1 month, 3 months, and 6 months.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about pain relief and functional improvement after 6 months?",{"text":121,"@type":113},"After 6 months, pain scores decreased by 75.3% and functional scores improved by 72.1%. Younger, non-diabetic patients and those with symptoms for less than 6 months showed more favorable outcomes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},447505,1790764526,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Original Article  Journal of Orthopaedic Case Reports 2025 December:15( 12) :Page 379-385   \nFunctional Outcome of Intra-articular Platelet-Rich Plasma in the  \nTreatment of Frozen Shoulder  \nGautham Saravanan¹, Prabhakaran Anbalagan¹, Ashok Ramanujam¹, Umar Farook1  \nLearning Point of the Article:  \nPlatelet-rich plasma (PRP) offers a safe, regenerative treatment for frozen shoulder, providing superior, and longer-lasting pain relief and functionalimprovement compared to corticosteroids. Its efficacy is higherin younger, non-diabetic patients with shorter symptom duration.  \nAbstract  \nIntroduction: Frozen shoulder, also known as adhesive capsulitis, is a condition marked by persistent shoulder pain and limited range of motion. Platelet-rich plasma (PRP) has recently gained attention as a biologically active therapy capable of enhancing tissue repair and regeneration.  \nObjective: This studyaimed to assessthe impact of intra-articular PRPinjectionson functionalrecovery in individuals with frozen shoulder. Materials and Methods: A prospective interventional study was performed involving 30 patients who had not responded to standard conservative therapies. Each participant received a single PRP injection and was monitored at intervals of 1 week, 1 month, 3 months, and 6 months. Pain and functional outcomes were measured using the visual analog scale (VAS) and disabilities of the arm, shoulder, and hand (DASH) scores. Subgroup analyses examined the effects ofage, diabetes status, and duration of symptoms.  \nFindings: After6 months, there was a75.3% reduction in pain scores anda 72.1% improvement in functional scores. Patients who wereyounger, non-diabetic, or had symptoms for \u003C6 months experienced more favorable outcomes. Multivariate analysis confirmed age, diabetes, and symptom duration as significant outcomepredictors.  \nConclusion: Intra-articular PRP injections appear to significantly reduce pain and enhance function inpatients with frozen shoulder, with the most pronounced benefits observed in early-stage, younger, non-diabetic individuals. Despite certain study limitations, these results highlight PRP’s potential asan effective treatment alternative.  \nKeywords: Platelet-rich plasma, frozen shoulder, adhesive capsulitis, intra-articular injection.  \nIntroduction  \nFrozen shoulder, or adhesive capsulitis, is aprogressively limiting musculoskeletal disorder marked by increasing pain, joint stiffness, and restricted movement of the shoulder joint [1]. It generally advances through three clinically recognized phases: The initial painful freezing stage, the intermediate frozen stage characterized by marked stiffness, and the thawing stage during which mobility gradually returns [2]. Although the precise cause  \nis not fully understood, several contributing factors have been identified, including metabolic disorders such as diabetes and thyroid dysfunction, periods of prolonged shoulder immobilization, and underlying autoimmune mechanisms [3]. The condition affects approximately 2–5% of the population, with the highest prevalence among individuals aged between 40 and 60years, and tends to occur morefrequentlyin women [4]. Standard treatment strategies for frozen shoulder encompass a  \n\n| \u003Cbr>Access this article online\u003Cbr>\u003Cbr>Website: [www.jocr.co.in](www.jocr.co.in)\u003Cbr>\u003Cbr>DOI:\u003Cbr>[https://doi.org/10.13107/jocr.2025.v15.i12.6566](https://doi.org/10.13107/jocr.2025.v15.i12.6566) | Author’s Photo Gallery |  |  |  |\n| --- | --- | --- | --- | --- |\n|  | \u003Cbr>Dr. Gautham Saravanan | | | |\n|  | \u003Cbr>1Department of Orthopaedics, Sri Balaji Vidyapeeth-Mahatma Gandhi Medical College and Research Institute, Puducherry, India.\u003Cbr>Address of Correspondence:\u003Cbr>Dr. Prabhakaran Anbalagan,\u003Cbr>Department of Orthopaedics, Sri Balaji Vidyapeeth-Mahatma Gandhi Medical College and Research Institute, Puducherry, India. [E-mail:](E-mail: medicothedoc@gmail.com)[ medicothedoc@gmail.com](E-mail: medicothedoc@gmail.com) |  |  |  |\n| Submitted: 17/09/202","cbCaiodjdc0Skz3o","https://ap.wps.com/l/cbCaiodjdc0Skz3o","pdf",6545888,"English","# Introduction\n## Objective\n## Materials and Methods\n## Findings\n## Conclusion\n# Keywords","[{\"question\":\"What condition does this study focus on, and why is it challenging to treat?\",\"answer\":\"The study focuses on frozen shoulder (adhesive capsulitis), which is characterized by persistent pain and limited shoulder range of motion. Treatment can be difficult, especially when standard conservative therapies fail.\"},{\"question\":\"How was platelet-rich plasma (PRP) administered and evaluated in the study?\",\"answer\":\"Thirty patients received a single intra-articular PRP injection. Pain and functional outcomes were measured using VAS and DASH scores at 1 week, 1 month, 3 months, and 6 months.\"},{\"question\":\"What did the study find about pain relief and functional improvement after 6 months?\",\"answer\":\"After 6 months, pain scores decreased by 75.3% and functional scores improved by 72.1%. Younger, non-diabetic patients and those with symptoms for less than 6 months showed more favorable outcomes.\"}]","Functional Outcome of Intra-articular Platelet-Rich Plasma in the Treatment of Frozen Shoulder | PDF",1790720971,18]