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Methods: an experimental ENG protocol evaluated animals after 10 consecutive days of exposure to organophosphate at intraperitoneal doses of 0.5 mg/kg/day and 1.0 mg/kg/day, compared with a control group receiving distilled water, using caloric ice (10°C) and outcome measures based on nystagmus frequency and slow-component angular velocity. Results and Conclusion: no statistically significant intergroup differences were observed, indicating no detectable functional damage at tested doses.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/functional-evaluation-of-the-vestibular-system-of-guinea-pigs-poisoned-by-an-organophosphate-through-caloric-stimulation/208894/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/functional-evaluation-of-the-vestibular-system-of-guinea-pigs-poisoned-by-an-organophosphate-through-caloric-stimulation/208894.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-19","2026-09-05",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the purpose of this study?","Question",{"text":113,"@type":114},"The study evaluated the functional status of the vestibular system in guinea pigs acutely exposed to chlorpyrifos using caloric stimulation and electronystagmography.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the experiment conducted?",{"text":118,"@type":114},"Guinea pigs were exposed for 10 consecutive days to organophosphate chlorpyrifos via intraperitoneal dosing (0.5 mg/kg/day or 1.0 mg/kg/day) and compared with a control group receiving distilled water, using caloric ice at 10°C during electronystagmography.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main findings and conclusion?",{"text":122,"@type":114},"The comparison of outcomes between groups showed no statistically significant differences, leading to the conclusion that the tested chlorpyrifos doses caused no detectable functional damage in the caloric test.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},208894,1788606961,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":130,"read_time":144},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Red de Revistas Científicas de América Latina, el Caribe, España y Portugal Sistema de Información Científica  \nEnglish version  \nCogo, Lícia Assunção; De Andrade Batista Murashima, Adriana; Alves Valentins dos Santos Filha, Valdete;  \nHyppolito, Miguel Angelo; Ferreira da Silveira, Aron  \nAVALIAÇÃO FUNCIONAL DO SISTEMA VESTIBULAR DE COBAIAS INTOXICADAS AGUDAMENTE POR  \nORGANOFOSFORADO POR MEIO DA PROVA CALÓRICA Revista CEFAC, vol. 16, núm. 5, septiembre-octubre, 2014 , pp. 1434-1442  \nInstituto Cefac  \nSão Paulo, Brasil  \nAvailable in: [http://www.redalyc.org/articulo.oa?id=169332702007](http://www.redalyc.org/articulo.oa?id=169332702007)  \nRevista CEFAC,  \nISSN (Printed Version): 1516-1846 [revistacefac@cefac.br](revistacefac@cefac.br)  \nInstituto Cefac  \nBrasil  \nHow to cite  \n Complete issue  \n More information about this article  \n Journal's homepage  \n\n| [www.redalyc.org](www.redalyc.org) |\n| --- |\n| Non-Profit Academic Project, developed under the Open Acces Initiative |\n\n1434  \nFUNCTIONAL EVALUATION OF THE VESTIBULAR SYSTEM OF GUINEA PIGS POISONED BY AN ORGANOPHOSPHATE THROUGH CALORIC STIMULATION  \nAvaliação funcional do sistema vestibular de cobaias intoxicadasagudamente por organofosforado por meio da prova calórica  \nLícia Assunção Cogo(1),Adriana de Andrade Batista Murashima(2), Valdete Alves Valentins dos Santos Filha (3), Miguel Angelo Hyppolito(4), Aron Ferreira da Silveira(5)  \nABSTRACT  \nPurpose: this study aimed to assess the functioning of the vestibular system of guinea pigs exposed to the organophosphate chlorpyrifos, acutely, through caloric stimulation electronystagmography. Methods: the research conducted an experimental electronystagmography of guinea pigs exposed to organophosphate for 10 consecutive days, at doses 0.5 mg / kg / day and 1.0 mg / kg / day intraperitoneally and compared with a control group that received distilled water administration. We performed caloric ice (10 º C) and compared the variables frequency of appearance of nystagmus in 10 seconds (u / s) and angular velocity of the slow component (º / s) . Results: the results showed no statistically significant difference in the comparison of variables between groups. Conclusion: we conclude that the tested doses of the pesticide organophosphate chlorpyrifos caused no detectable functional damage in the caloric test.  \nKEYWORDS: Postural Balance; Vestibule, Labyrinth; Insecticides, Organophosphate; Pesticides; Drug Toxicity  \n􀂄 INTRODUCTION  \nBody balance is maintained by the joint operation of three structures: the vestibular system, the visual system and the proprioceptive system. The vestibular system detects the sensations of balance, assisting in the coordination of head and eye movements, and also in adjustments of body posture. Dysfunctions  \n(1) Federal University of Pampa – Uruguaiana Campus, Uruguaiana, Brazil.  \n(2) University of São Paulo, Ribeirão Preto, SP, Brazil.  \n(3) Federal University of Santa Maria – UFSM, Santa Maria, Brazil.  \n(4) Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Ribeirão Preto, University of São Paulo. Ribeirão Preto – SP, Brazil.  \n(5) Federal University of Santa Maria – UFSM, Santa Maria, RS, Brazil.  \nFunding agency: Capes  \nConflict of interest: non-existent  \nRev. CEFAC. 2014 Set-Out; 16(5):1434-1442  \nin this system may result in unpleasant sensations such as dizziness, nausea and a feeling of imbalance accompanied by uncontrollable eye movements, i.e. , nystagmus1,2 . In humans, the vestibular system consists of three key components: a peripheral sensory system, a central processor, and a motor response mechanism. The peripheral system consists of a set of motion sensors which send  \ninformation to the central nervous system (CNS)3.  \nThe central vestibular system produces a response to head movement which is transmitted to the extraocular muscles and the spinal cord, triggering the vestibulo-ocular reflex (VOR) and vestibulo-spinal reflex (VSR)","cbCaiafJ028saNzR","https://ap.wps.com/l/cbCaiafJ028saNzR","pdf",1039597,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the purpose of this study?\",\"answer\":\"The study evaluated the functional status of the vestibular system in guinea pigs acutely exposed to chlorpyrifos using caloric stimulation and electronystagmography.\"},{\"question\":\"How was the experiment conducted?\",\"answer\":\"Guinea pigs were exposed for 10 consecutive days to organophosphate chlorpyrifos via intraperitoneal dosing (0.5 mg/kg/day or 1.0 mg/kg/day) and compared with a control group receiving distilled water, using caloric ice at 10°C during electronystagmography.\"},{\"question\":\"What were the main findings and conclusion?\",\"answer\":\"The comparison of outcomes between groups showed no statistically significant differences, leading to the conclusion that the tested chlorpyrifos doses caused no detectable functional damage in the caloric test.\"}]","FUNCTIONAL EVALUATION OF THE VESTIBULAR SYSTEM OF GUINEA PIGS POISONED BY AN ORGANOPHOSPHATE THROUGH CALORIC STIMULATION | PDF",25]