[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338040-105":59,"doc-detail-338040-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","function-and-mechanism-of-action-of-the-trpv1-channel-in-the-development-of-triple-negative-breast-cancer","Function and mechanism of action of the TRPV1 channel in the development of triple-negative breast cancer","","Transient receptor potential channel subfamily vanilloid 1 (TRPV1) is a nonselective, cationic transmembrane channel protein regulating calcium homeostasis. It is expressed across multiple tumors and is linked to cancer growth, metastasis, apoptosis, and cancer-related pain. TRPV1 is highly expressed in triple-negative breast cancer (TNBC), and both agonists and antagonists may produce anti-cancer effects. This review outlines TRPV1’s role in TNBC development and its potential impact on immunotherapy to support future treatment strategies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/function-and-mechanism-of-action-of-the-trpv1-channel-in-the-development-of-triple-negative-breast-cancer/338040/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/function-and-mechanism-of-action-of-the-trpv1-channel-in-the-development-of-triple-negative-breast-cancer/338040.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is TRPV1 and what role does it play in cells?","Question",{"text":113,"@type":114},"TRPV1 is a nonselective cationic transmembrane channel protein involved in regulating calcium homeostasis. It has been implicated in multiple aspects of cancer biology including growth, metastasis, and apoptosis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How is TRPV1 related to triple-negative breast cancer (TNBC)?",{"text":118,"@type":114},"TRPV1 is highly expressed in TNBC. The review notes that both TRPV1 agonists and antagonists may exert anti-cancer effects in this disease context.",{"name":120,"@type":111,"acceptedAnswer":121},"Why is the review focused on developing treatment strategies for TNBC?",{"text":122,"@type":114},"Because existing therapies do not adequately address recurrence and metastasis, particularly in TNBC, the document emphasizes the need for comprehensive therapies and specific therapeutic targets. 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Tel: +86-13510890238; E-mail: [mdcg2014bl@163.com](mdcg2014bl@163.com) (X. L. ) / Tel: +86-13769180810; E-mail: [kongyanjie26@163.com](kongyanjie26@163.com) (Y. K. ) Received 26 November 2023 Accepted 25 March 2024  \nAbstract  \nTransient receptor potential channel subfamily vanilloid 1 (TRPV1) is a member of the transient receptor potential family of nonselective cationic transmembrane channel proteins that are involved in the regulation of calcium homeostasis. It is expressed in various tumor types and has been implicated in the regulation of cancer growth, metastasis, apoptosis, and cancer-related pain. TRPV1 is highly expressed in triple-negative breast cancer (TNBC), and both its agonists and antagonists may exert anti-cancer effects. In this review, we provide an overview of the effect of TRPV1 on TNBC development and its influence on immunotherapy in an attempt to facilitate the development of future treatment strategies.  \nKey words ion channel, TRPV1, breast cancer, TNBC  \nIntroduction  \nIn 2020, for the first time, the incidence and mortality rates of breast cancer in women increased significantly compared to those of women with lung cancer [1] . The latest statistics on the incidence and mortality of new cancers in China show that breast cancer is the most common tumor among females, and its mortality rate is on a continuous rise [2] . Breast cancer is classified into six subtypes based on molecular phenotype and gene expression, namely, luminal-A, luminal-B, HER-2 positive, basal-like (BLBC), normallike [3] and claudin low [4] . Nearly 70%–80% of BLBC cases are triple-negative breast cancer (TNBC) [5] . Breast cancer is a highly heterogeneous disease with wide variations in its clinical management and prognosis. Existing treatment strategies for breast cancer include surgical resection, chemotherapy, radiotherapy, endocrine therapy, and targeted therapy; however, none of these therapies have adequately addressed the problems of recurrence and metastasis, particularly in TNBC patients. Although PARP inhibitors are indicated for patients with breast cancer carrying BRCA mutations, they do not prolong the overall survival of these patients [6] . In recent years, the immune checkpoint inhibitor (ICI) atezolizumab (which targets PD-L1) in combination with albuminpaclitaxel has shown considerable efficacy against PD-L1-positive infiltrating lymphocytes in TNBC, thereby extending overall patient survival. However, the proportion of the population benefiting from  \nthis regimen is small [7], and this regimen was voluntarily withdrawn by Roche in 2021. The anti-PD-1 pembrolizumab combination chemotherapy regimen significantly improves survival to disease progression in patients with locally advanced breast cancer [8] and increases the rate of complete remission in patients receiving neoadjuvant treatment for early-stage TNBC [9] . Due to the lack of effective treatment options, the development of comprehensive therapies and specific therapeutic targets is urgently needed.  \nTransient receptor potential (TRP) channels are a family of cationic proteins. TRPV5 and TRPV6 are specific calcium channels, while the other members are nonselective [10] . Based on amino acid sequence homology, the mammalian TRP superfamily is divided into six subfamilies: the ankyrin (TRPA), canonical (TRPC), melastatin (TRPM), vanilloid (TRPV), mucolipin (TRPML), and polycytin (TRPP) subfamilies [11] . TRP channel activation is stimulated by various physical or chemical factors both inside and outside the cell, including diglycerides (DAG), inositol trisphosp","cbCaieISOfiQ7snG","https://ap.wps.com/l/cbCaieISOfiQ7snG","pdf",325639,"English","# Abstract\n# Introduction\n## Breast cancer background and treatment challenges\n## TRP channels and tumor biology\n## Rationale for focusing on TRPV1 in TNBC","[{\"question\":\"What is TRPV1 and what role does it play in cells?\",\"answer\":\"TRPV1 is a nonselective cationic transmembrane channel protein involved in regulating calcium homeostasis. It has been implicated in multiple aspects of cancer biology including growth, metastasis, and apoptosis.\"},{\"question\":\"How is TRPV1 related to triple-negative breast cancer (TNBC)?\",\"answer\":\"TRPV1 is highly expressed in TNBC. The review notes that both TRPV1 agonists and antagonists may exert anti-cancer effects in this disease context.\"},{\"question\":\"Why is the review focused on developing treatment strategies for TNBC?\",\"answer\":\"Because existing therapies do not adequately address recurrence and metastasis, particularly in TNBC, the document emphasizes the need for comprehensive therapies and specific therapeutic targets. It highlights TRPV1’s potential effects and relevance to immunotherapy as a basis for future strategies.\"}]","Function and mechanism of action of the TRPV1 channel in the development of triple-negative breast cancer | PDF",1790021682,15]