[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-356332-105":59,"doc-detail-356332-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","fto-promotes-the-cervical-cancer-progression-via-regulation-of-fgf2-expression","FTO promotes the cervical cancer progression via regulation of FGF2 expression","","Cervical cancer is a common gynecological malignancy in which epigenetic RNA modifications contribute to disease development. This study examines the role of fat mass and obesity-associated protein (FTO) in cervical cancer progression and its relationship with N6-methyladenosine (m6A) RNA methylation, emphasizing Fibroblast Growth Factor 2 (FGF2) as a downstream mediator. Elevated FTO is detected in tumor tissues and cell lines with reduced m6A levels. FTO overexpression decreases m6A, promotes proliferation, and suppresses apoptosis, while FTO knockdown reverses these effects via reduced FGF2. Targeting the FTO–FGF2/m6A axis is proposed as a therapeutic strategy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fto-promotes-the-cervical-cancer-progression-via-regulation-of-fgf2-expression/356332/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fto-promotes-the-cervical-cancer-progression-via-regulation-of-fgf2-expression/356332.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this study on cervical cancer?","Question",{"text":112,"@type":113},"To determine how FTO influences cervical cancer progression through m6A RNA methylation, focusing on FGF2 as a key downstream mediator.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the researchers measure FTO and m6A-related changes?",{"text":117,"@type":113},"They analyzed FTO expression in tissues and cell lines using immunohistochemistry, Western blot, and q-PCR, and assessed m6A modification levels accordingly.",{"name":119,"@type":110,"acceptedAnswer":120},"What happens to cell proliferation and apoptosis when FTO is manipulated?",{"text":121,"@type":113},"FTO overexpression decreases global m6A, increases cell proliferation, and reduces apoptosis, while FTO knockdown reduces proliferation and increases apoptosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},356332,1790252882,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Experimental Research  \nFTO promotes the cervical cancer progression via regulation of FGF2 expression  \nJie Chen, MD, PhDa , Yun Gu, MDb , Ying Zheng, MDc , Min Gu, MDa , Chenyi Yang, MDa , Chunping Ye, MD, PhDa ,*  \nBackground: Cervical cancer remains one of the most common gynecological malignancies worldwide, with epigenetic RNA modifications playing a critical role in its development. This study aims to investigate the role of fat mass and obesity-associated protein (FTO) in cervical cancer progression and its impact on N6-methyladenosine (m6A) RNA methylation, focusing on Fibroblast Growth Factor 2 (FGF2) as a key downstream mediator.  \nMethods: We analyzed FTO expression in adjacent normal and cervical cancer tissues by using immunohistochemistry (IHC), Western blot, and q-PCR. We also examined FTO expression and m6A modification levels in cervical cancer cell lines versus control cell lines. To investigate the impact of FTO overexpression and knockdown on cell proliferation and apoptosis, a series of functional assays, including CCK-8, flow cytometry, and immunofluorescence staining, were carried out. Furthermore, we investigated the regulation of FGF2 by FTO using the GEPIA database, qRT-PCR, and Western blot.  \nResults: There was a notable elevation of FTO expression in cervical cancer tissues as opposed to the adjacent normal tissues. Increased levels of FTO protein and mRNA were detected in tumor tissues, along with reduced m6A modification levels of FTOmRNA. Cervical cancer cells showed higher FTO expression and decreased m6A modification compared to control cell lines. Enhanced FTO expression in HeLa cells resulted in lower global m6A levels, increased cell proliferation, and reduced apoptosis. Conversely, FTO knockdown led to reduced cell proliferation, reduced FGF2 mRNA and protein levels, diminished lactate production, and impaired cell proliferation, and increased apoptosis.  \nConclusion: FTO significantly influences cervical cancer progression, at least in part, through m6A modification of FGF2, thereby affecting downstream signaling. Targeting FTO and its downstream effectors holds potential as a therapeutic strategy for cervical cancer treatment.  \nKeywords: apoptosis, cell proliferation, cervical cancer, FGF2, FTO, m6A RNA methylation  \nIntroduction  \nCervical cancer continues to be one of the primary contributors to cancer-related illness and death among women worldwide,  \naDepartment of Obstetrics and Gynecology, Nanjing Maternity and Child Health Care Hospital, Women’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, China, bDepartment of Pathology, Nanjing Maternity and Child Health Care Hospital, Women’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, China and cDepartment of Obstetrics and Gynecology, Shandong Second Provincial General Hospital, Jinan, Shandong, China  \nJie Chen, Yun Gu, and Ying Zheng contributed equally to this work.  \nSponsorships or competing interests that may be relevant to content are disclosed at the end of this article.  \n*Corresponding author. Address: Department of Obstetrics and Gynecology, Nanjing Maternity and Child Health Care Hospital, Women’s Hospital of Nanjing Medical University, 123 Mochou Rd, Nanjing 210004, Jiangsu, China.  \nTel.: +[86-25-52226777. E-mail: ycpcj2023@gmail.com](86-25-52226777. E-mail: ycpcj2023@gmail.com) (C. Ye).  \nCopyright © 2026 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nAnnals of Medicine & Surgery (2026) 88:1359–1368  \nReceived 4 August 2025; Accepted 4 December 2025  \nSupplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PD","cbCaivR3zMMG8JiI","https://ap.wps.com/l/cbCaivR3zMMG8JiI","pdf",2212030,"English","# Background\n# Methods\n## Tissue and molecular analyses\n## Cell-line functional assays\n## Regulation of FGF2 by FTO\n# Results\n## FTO and m6A alterations\n## Effects of FTO overexpression\n## Effects of FTO knockdown\n# Conclusion\n# Highlights","[{\"question\":\"What is the main purpose of this study on cervical cancer?\",\"answer\":\"To determine how FTO influences cervical cancer progression through m6A RNA methylation, focusing on FGF2 as a key downstream mediator.\"},{\"question\":\"How did the researchers measure FTO and m6A-related changes?\",\"answer\":\"They analyzed FTO expression in tissues and cell lines using immunohistochemistry, Western blot, and q-PCR, and assessed m6A modification levels accordingly.\"},{\"question\":\"What happens to cell proliferation and apoptosis when FTO is manipulated?\",\"answer\":\"FTO overexpression decreases global m6A, increases cell proliferation, and reduces apoptosis, while FTO knockdown reduces proliferation and increases apoptosis.\"}]","FTO promotes the cervical cancer progression via regulation of FGF2 expression | PDF",1790124804,25]