[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-437202-en":59,"doc-seo-437202-105":80},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":72,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":39,"preview_page_count":4},437202,2336477405376,"Stanley","https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","From Mild Discomfort to Myopericarditis - A Complication of Patent Foramen Ovale Occluder Device Placement - A Case Report","A 43-year-old woman underwent successful elective closure of a large aneurysmal patent foramen ovale (PFO) using a GORE CARDIOFORM Septal Occluder. She developed mild chest discomfort immediately after the procedure and was discharged after echocardiography confirmed correct device positioning. The next day, worsening pleuritic chest pain and diagnostic ECG, laboratory, and imaging findings led to myopericarditis. Colchicine and ibuprofen achieved complete symptom resolution.","Journal of the Society for Cardiovascular Angiography & Interventions 4 (2025) 104044  \nJSCAI Case Report  \nFrom Mild Discomfort to Myopericarditis—A Complication of Patent Foramen Ovale Occluder Device Placement: A Case Report Anastasia Proshkina, MD a, *, Jonathan Shpigelman, MD a, Rami Al Ayyubi, MD b, Mohamad Bahrou, MD a, Ra’ad Al Tamimi, MDb, Ahmad Al Turk, MDb  \na Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois; b Division of Cardiology, Southern Illinois University School of Medicine, Springfield, Illinois  \n| A B S T R A C T |\n| --- |\n| A 43-year-old woman underwent successful elective closure of a large aneurysmal patent foramen ovale (PFO) using a GORE CARDIOFORM Septal Occluder. She experienced mild chest discomfort immediately postprocedure but was discharged after a transthoracic echocardiogram confirmed appropriate device positioning and no acute abnormalities. She returned the following day with worsening pleuritic chest pain unresponsive to acetaminophen and ibuprofen. Her clinical presentation, together with her electrocardiogram, laboratory, and imaging findings, was diagnostic of myopericarditis. She was treated with colchicine and ibuprofen, resulting in complete symptom resolution. This case illustrates a rare complication of PFO closure, potentially related to nickel hypersensitivity. Currently, no validated tools exist to predict such hypersensitivity reactions, and nickel-free PFO closure devices are not commercially available. Until alternatives become available, clinicians must balance the risk of hypersensitivity reactions against the proven benefit of PFO closure in preventing recurrent stroke in select patients. |\n\nCase presentation  \nA 43-year-old woman with a history of cryptogenic stroke was found to have a large aneurysmal patent foramen ovale (PFO) . She underwent elective, successful intracardiac echocardiography (ICE) -guided closure with a 30 mm GORE CARDIOFORM Septal Occluder (Figure 1A-D) . Immediately postprocedure, she developed leftsided, substernal chest pain. Electrocardiogram (ECG) showed normal sinus rhythm (Figure 2A) and laboratory evaluation revealed only mild elevations in her white blood cell count (12.4 K/μL) and high-sensitivity troponin level (35.7 pg/mL) . No intraprocedural complications were noted, and a transthoracic echocardiogram confirmed correct device positioning without wall motion abnormalities or pericardial effusion. She was discharged the following morning on aspirin and clopidogrel. Later that day, she returned to the emergency department with persistent sharp, pleuritic, and positional chest pain associated with dyspnea, unrelieved by acetaminophen or ibuprofen. Repeat workup revealed worsening leukocytosis (17.0 K/μL), marked troponin elevation (peaked at 8559.4 pg/mL), elevated inflammatory markers (C-reactive protein 119.9 mg/L, erythrocyte sedimentation rate of 24 mm/h), diffuse concave ST-segment elevations on ECG (Figure 2B), and a trace  \npericardial effusion on both computed tomography angiography (Figure 3A) and transthoracic echocardiogram (Figure 3B)—findings concerning for myopericarditis. COVID-19 testing was negative during her initial admission, and she exhibited no other symptoms of viral illness; hence, additional viral testing was deferred. On further questioning, the patient reported prior skin reactions to nickel jewelry, although no formal allergy testing was conducted pre- or postprocedure . She was treated with colchicine and ibuprofen, resulting in rapid symptom improvement. At the 3-month followup, cardiac magnetic resonance imaging showed no residual inflammation, and additional autoimmune serologies (antinuclear antibodies, rheumatoid factor, anti-SS-A/SS-B antibodies) were negative.  \nDiscussion  \nMyopericarditis refers to concurrent inflammation of the pericardium and myocardium, most commonly caused by viral infections but occasionally triggered by cardiac interventions. A","cbCailwPbnvQIi53","https://ap.wps.com/l/cbCailwPbnvQIi53","pdf",7347517,3,"English","en",105,"# Abstract\n# Case presentation\n## Proposed mechanisms\n# Discussion","[{\"question\":\"What triggered the diagnosis of myopericarditis after PFO closure?\",\"answer\":\"The patient developed worsening pleuritic chest pain with diagnostic ECG changes, marked troponin elevation, inflammatory marker rise, and imaging evidence including a trace pericardial effusion.\"},{\"question\":\"How was the patient treated, and what was the outcome?\",\"answer\":\"Treatment with colchicine and ibuprofen led to rapid symptom improvement, with follow-up cardiac magnetic resonance imaging at 3 months showing no residual inflammation.\"},{\"question\":\"Why might nickel hypersensitivity be relevant to this complication?\",\"answer\":\"The report suggests a potential link to type IV hypersensitivity to nickel, a component of nitinol used in PFO closure devices, while noting that no validated prediction tools or nickel-free devices are currently available.\"}]","From Mild Discomfort to Myopericarditis - A Complication of Patent Foramen Ovale Occluder Device Placement - A Case Report | PDF",1790680618,{"code":4,"msg":81,"data":82},"ok",{"site_id":75,"language":74,"slug":83,"title":65,"keywords":84,"description":66,"schema_data":85,"social_meta":138,"head_meta":140,"extra_data":142,"updated_unix":143},"from-mild-discomfort-to-myopericarditis-a-complication-of-patent-foramen-ovale-occluder-device-placement-a-case-report","",{"@graph":86,"@context":137},[87,100,120],{"@type":88,"itemListElement":89},"BreadcrumbList",[90,94,96,98],{"item":91,"name":92,"@type":93,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":95,"name":9,"@type":93,"position":14},"https://docshare.wps.com/document/",{"item":97,"name":35,"@type":93,"position":72},"https://docshare.wps.com/document/healthcare/",{"item":99,"name":65,"@type":93,"position":19},"https://docshare.wps.com/document/from-mild-discomfort-to-myopericarditis-a-complication-of-patent-foramen-ovale-occluder-device-placement-a-case-report/437202/",{"url":99,"name":65,"@type":101,"image":102,"author":107,"headline":65,"publisher":109,"fileFormat":112,"inLanguage":74,"description":66,"dateModified":113,"datePublished":114,"encodingFormat":112,"isAccessibleForFree":115,"interactionStatistic":116},"DigitalDocument",{"url":103,"@type":104,"width":105,"height":106},"https://docshare.wps.com/thumbnails/from-mild-discomfort-to-myopericarditis-a-complication-of-patent-foramen-ovale-occluder-device-placement-a-case-report/437202.png","ImageObject",300,407,{"name":63,"@type":108},"Person",{"url":91,"name":110,"@type":111},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":117,"interactionType":118,"userInteractionCount":39},"InteractionCounter",{"@type":119},"ViewAction",{"@type":121,"mainEntity":122},"FAQPage",[123,129,133],{"name":124,"@type":125,"acceptedAnswer":126},"What triggered the diagnosis of myopericarditis after PFO closure?","Question",{"text":127,"@type":128},"The patient developed worsening pleuritic chest pain with diagnostic ECG changes, marked troponin elevation, inflammatory marker rise, and imaging evidence including a trace pericardial effusion.","Answer",{"name":130,"@type":125,"acceptedAnswer":131},"How was the patient treated, and what was the outcome?",{"text":132,"@type":128},"Treatment with colchicine and ibuprofen led to rapid symptom improvement, with follow-up cardiac magnetic resonance imaging at 3 months showing no residual inflammation.",{"name":134,"@type":125,"acceptedAnswer":135},"Why might nickel hypersensitivity be relevant to this complication?",{"text":136,"@type":128},"The report suggests a potential link to type IV hypersensitivity to nickel, a component of nitinol used in PFO closure devices, while noting that no validated prediction tools or nickel-free devices are currently available.","https://schema.org",{"og:url":99,"og:type":139,"og:title":65,"og:site_name":110,"og:description":66},"article",{"robots":141,"canonical":99},"index,follow",{"doc_id":61,"site_id":75},1791168621]