[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458833-105":59,"doc-detail-458833-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","from-blood-vessels-to-lymphatics-and-back-again-editorial-focus","From blood vessels to lymphatics and back again - Editorial Focus","","Editorial focus on how research insights move between vascular and lymphatic systems to improve understanding of fluid transport and vessel function. Highlights Davis and King’s work using servo-nulling micropipette pressure measurements in isolated mouse veins to link venous smooth muscle tone with impaired venous valve closure and leakage. Discusses method extensions from lymphangions, emerging mechanistic questions about valve number, heterogeneity, and disease-related dysfunction, while noting the need for future pressure-measuring expertise.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/from-blood-vessels-to-lymphatics-and-back-again-editorial-focus/458833/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/from-blood-vessels-to-lymphatics-and-back-again-editorial-focus/458833.png","ImageObject",300,407,{"name":92,"@type":93},"Alexandar","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What central connection does the editorial emphasize between blood vessels and lymphatics?","Question",{"text":112,"@type":113},"It emphasizes that recognizing overlaps between the lymphatic and vascular systems helps researchers transfer methods and understanding to clarify how lymphatic vessels work and how lymphatic insights can advance knowledge of blood vessel function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What do the reported results suggest about venous tone and venous valve closure?",{"text":117,"@type":113},"They implicate a causal relationship in which venous tone affects venous valve closure, with loss of tone associated with impaired closure and valve leak.",{"name":119,"@type":110,"acceptedAnswer":120},"Which key scientific questions does the editorial raise for future study?",{"text":121,"@type":113},"It asks how many valves are needed along veins, whether venous valves are heterogeneous, whether heterogeneity matters, whether rescuing venous tone can improve valve function, and how these relationships may explain dysfunction in disease states.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458833,1790754558,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":24,"preview_page_count":4},962090768658,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","FUNCTION 7: e102-2025, 2026 .  \nFirst published December 8, 2025; doi:10.1152/function.102.2025  \nEDITORIAL FOCUS  \nFrom blood vessels to lymphatics and back again  \nWalter L. Murfee1 and Jerome W. Breslin2  \n1J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States and 2Department of Molecular Pharmacology & Physiology, University of South Florida, Tampa, Florida, United States  \nFrom blood vessels to lymphatics and back again—the path for fluid transport from the circulation, through the interstitial space, into lymphatic capillaries, and eventually back into large veins, in many ways parallels the impacts made by researchers during our careers. Recognizing the overlaps between both systems, leading vascular physiologists leveraged opportunities to apply methods, approaches, and a fundamental understanding to elucidate how lymphatic vessels work (1, 2) . In this journal, Davis and King (3) provide a nice example of in turn applying what they have learned about lymphatic function to advance our understanding of how blood vessels work (Fig. 1). Based on servo-nulling micropipette pressure measurements in isolated veins from mice, the results implicate a causal relationship between venous tone and venous valve closure.  \nFigure 1. Application of our lymphatic biology understanding to advance our understanding of how venous valves work. The study by Davis and King (3) extends technically challenging measurements of pressures within isolated vessels and endothelial specific reporter mice used to characterize secondary lymphatic valve structure and function to suggest an underappreciated mechanism relating loss of venous tone and impaired venous valve closure. The study motivates the conceptual advance in the context of what can be learned by recognizing the overlaps between lymphatic and vascular research. Printed with permission from Anita lmpagliazzo © 2025.  \nThe work refreshingly extends methods used to describe pressure differences across valves in isolated lymphangions (4, 5) to link the contractile state of venous smooth muscle cells to venous valve leak. Scientific rigor is highlighted by a simple story based on technically challenging physiology methods, which are less common these days, probably due to the length of required training time and the juxtaposition with pace-driven pressures of academic research. The application of the old methods provokes new questions andreconsideration of what we know about venous smooth muscle cell constriction and venous valve function. How many valves are needed along veins? Are venous valves heterogenous? Does heterogeneity matter? Can rescuing venous tone improve venous valve function? Can the relationship between venous tone and valve function explain dysfunction associated with disease states? As Dr. Davis passes his servonulling systems to the next generation of vascular physiologists, maybe the most pressing question is—who will be measuring pressures?  \n GRANTS  \nEffort associated with this editorial was supported by the fund provided by American Heart Association (AHA) ward 23TPA1142184 (to W.L. M.) and NIH R35GM145379 (to J.W. B.) .  \n DISCLAIMERS  \nThe content and any opinions expressed in this article are those of the authors and do not necessarily represent the views of the American Physiological Society.  \n DISCLOSURES  \nNo conflicts of interest, financial or otherwise, are declared by the authors.  \n AUTHOR CONTRIBUTIONS  \nW.LM.: Conceptualization, Writing–original draft; J.W. B.: Conceptualization, Writing–original draft.  \n REFERENCES  \n1. Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL.  \nLymphatic vessel network structure and physiology. Compr Physiol 9: 207–299, 2018. doi:10.1002/cphy.c180015.  \nCorrespondence: W. L. Murfee (wmurfee@bme.ufl.edu) .  \nSubmitted 19 November 2025 / Accepted 20 November 2025  \n2633-8823/26 Copyright © 2026 The Authors. Licensed under Creative Commons Attribution C","cbCaivKISl7d3kcI","https://ap.wps.com/l/cbCaivKISl7d3kcI","pdf",437185,"English","# Editorial Focus: From blood vessels to lymphatics and back again\n## Research connection between lymphatic and vascular systems\n## Key findings on venous tone and valve closure\n## Grants, disclaimers, disclosures, and author contributions\n## References and publication details","[{\"question\":\"What central connection does the editorial emphasize between blood vessels and lymphatics?\",\"answer\":\"It emphasizes that recognizing overlaps between the lymphatic and vascular systems helps researchers transfer methods and understanding to clarify how lymphatic vessels work and how lymphatic insights can advance knowledge of blood vessel function.\"},{\"question\":\"What do the reported results suggest about venous tone and venous valve closure?\",\"answer\":\"They implicate a causal relationship in which venous tone affects venous valve closure, with loss of tone associated with impaired closure and valve leak.\"},{\"question\":\"Which key scientific questions does the editorial raise for future study?\",\"answer\":\"It asks how many valves are needed along veins, whether venous valves are heterogeneous, whether heterogeneity matters, whether rescuing venous tone can improve valve function, and how these relationships may explain dysfunction in disease states.\"}]","From blood vessels to lymphatics and back again - Editorial Focus | PDF"]