[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-362623-105":3,"doc-detail-362623-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","frequency-of-heart-cancer-evidence-based-study-of-occurrence","Frequency of Heart Cancer - Evidence-Based Study of Occurrence","","From 1931 to 2025, cardiac cancer has been characterized as a rare and sporadic tumor with major investigative and therapeutic difficulties. Autopsy evidence suggests primary cardiac malignancies occur at about 0.02%. This study evaluates cardiac cancer in Isfahan Province, Iran, using representative population data and SEER records (2011–2015), applying SAGER-guided selection and ICD-O topography C38 classification.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/frequency-of-heart-cancer-evidence-based-study-of-occurrence/362623/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/frequency-of-heart-cancer-evidence-based-study-of-occurrence/362623.png","ImageObject",300,407,{"name":42,"@type":43},"Riley West","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of this study on cardiac cancer in Isfahan Province?","Question",{"text":63,"@type":64},"The study provides an overall assessment of cardiac cancer and details its frequency and demographic characteristics.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the data and case classification handled in the study?",{"text":68,"@type":64},"Representative data were taken from the general population of Isfahan Province, and SEER data (2011–2015) were used. Case selection followed SAGER guidelines and ICD-O topography code C38 was used for heart cancer/cardiac tumors.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the key findings regarding cardiac cancer frequency and demographics?",{"text":72,"@type":64},"Among 30,465 cancer patients, 122 cases (0.4%) were identified as cardiac cancer, with more cases in males than females. Patient ages ranged from 3 to 95 years, and 51% fell within 40–70 years.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},362623,1790790674,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc",7,"Zahra Tolou-Ghamari 1,*  \n1Nutrition and Food Security Research Center, Deputy of Research and Technology, Isfahan University of Medical Sciences, Isfahan, Iran  \nCurrent Cardiology Reviews  \nAbstract: Introduction: From 1931 to 2025, spanning 94 years, cardiac cancer has remained a rare and sporadic tumor that poses both an investigative dilemma and a therapeutic challenge. Autopsy findings indicate that the incidence of primary cardiac malignancies is approximately 0.02 percent. Surgical resection is considered a viable and often successful treatment option. Aims: The present study aims to provide an overall assessment of cardiac cancer in Isfahan Province, Iran.  \nObjectives: To provide detailed information on specific aspects, such as frequency and demographic characteristics of cardiac cancer.  \nMethods: The representative data of this study were drawn from the general population of Isfahan Province. SEER (Surveillance, Epidemiology, and End Results) data were obtained from the Deputy of Health, Division of Registry of Cancer (between 2011 and 2015) . With attention to subject selection (the authors followed the Sex and Gender Equity in Research (SAGER) Guidelines), and according to the ICDO topography code, C38 was considered for further investigation as heart cancer or cardiac tumors.  \nResults and Discussion: During the study period, a total of 30,465 cancer patients were recorded, comprising 14,638 females and 15,827 males. Among these, 122 cases (0.4 percent) were identified as cardiac cancer, including 42 females and 80 males. The patients' ages ranged from 3 to 95 years, with a mean age of 46.8 ± 21.5 years. The annual distribution of reported cardiac tumors during the study period was as follows: 34, 37, 18, and 33 cases, respectively. Based on available data from the monographic code M, which does not specify subtypes, the following conditions were recorded: mesothelioma (n = 25), neoplasm (n = 11), Hodgkin lymphoma, nodular sclerosis, NOS (n = 14), and other unspecified conditions. A total of three deaths were reported.  \nConclusion: In the population studied, the frequency of cardiac cancer in men was significantly higher than in women. Age related to cardiac cancer in 51% was between 40-70 years old. For the patient satisfaction and financial aspects of the Iranian health system, further consideration is suggested regarding referral systems, evidence-based pharmacotherapy, and post-surgery outcome inquiries.  \nKeywords: Frequency, tumors, cardiac cancer, SEER, SAGER, pharmacotherapy.  \n1. INTRODUCTION  \nCardiac cancer is an enormously erratic form of cancer that is separated into primary and secondary tumors of the heart. Cardiac tumors can occur in any part of the heart. Historically, valvular tumors were first described by Yater in 1931, followed a few years later by Campbell and Carling, who reported a tumor on the aortic valve. In 1975, cardiac papillary fibroelastoma was identified and described by  \n*Address correspondence to this author at the Nutrition and Food Security Research Center, Deputy of Research and Technology, Isfahan University of Medical Sciences, Isfahan, Iran; E-mail: [toloeghamari@pharm.mui.ac.ir](toloeghamari@pharm.mui.ac.ir)  \nCheitlin et al. [1, 2] . The infrequent cardiac tumors can be primary or metastatic [3] . The frequency of cardiac tumors has been estimated at approximately 200 cases per one million autopsies. Cardiac cancer may lead to complications such as valvular or inflow-outflow tract obstruction, thromboembolism, arrhythmias, and pericardial disorders. The diagnosis is difficult in most patients because there are nonspecific symptoms such as dyspnea, night sweats, weight loss, nausea, vomiting, fever, and fatigue [4] . The rare heart cancer initiates with myxomas, fibromas, rhabdomyomas, and hamartomas [5] . The most common primary tumor of the heart is reported as a myxoma, accounting for marginally more than half of all primary cardiac tumors [3] . The recent-  \n108  ","cbCaigmXH5HJLfep","https://ap.wps.com/l/cbCaigmXH5HJLfep","pdf",2425516,6,"English","# Abstract\n## Introduction\n## Objectives\n## Methods\n## Results and Discussion\n## Conclusion\n# Keywords\n# 1. INTRODUCTION","[{\"question\":\"What is the main purpose of this study on cardiac cancer in Isfahan Province?\",\"answer\":\"The study provides an overall assessment of cardiac cancer and details its frequency and demographic characteristics.\"},{\"question\":\"How were the data and case classification handled in the study?\",\"answer\":\"Representative data were taken from the general population of Isfahan Province, and SEER data (2011–2015) were used. Case selection followed SAGER guidelines and ICD-O topography code C38 was used for heart cancer/cardiac tumors.\"},{\"question\":\"What were the key findings regarding cardiac cancer frequency and demographics?\",\"answer\":\"Among 30,465 cancer patients, 122 cases (0.4%) were identified as cardiac cancer, with more cases in males than females. Patient ages ranged from 3 to 95 years, and 51% fell within 40–70 years.\"}]","Frequency of Heart Cancer - Evidence-Based Study of Occurrence | PDF",1790148586,15,{"code":4,"msg":82,"data":100},[101,105,109,113,118,122,125,129,134,137,141],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":92,"doc_module":4,"doc_module_name":25,"category_name":119,"show_sort_weight":120,"slug":121},"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":123,"slug":124},40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":126,"show_sort_weight":127,"slug":128},"Research & Report",30,"research-report",{"id":130,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},9,"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":138,"doc_module":4,"doc_module_name":25,"category_name":139,"show_sort_weight":138,"slug":140},10,"Lifestyle","lifestyle",{"id":142,"doc_module":4,"doc_module_name":25,"category_name":143,"show_sort_weight":114,"slug":144},19,"General","general"]