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Using prior findings from a rat colon adenocarcinoma model, the study evaluates whether free methylglyoxal (MG) measured in blood discriminates tumor growth from non-growing tumor cell clones. It compares cancer patients with healthy subjects and non-cancerous diabetic patients, quantifying MG in peripheral blood, tumors, and corresponding non-cancer tissues.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/free-methylglyoxal-as-a-metabolic-new-biomarker-of-tumor-cell-proliferation-in-cancers/329591/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/free-methylglyoxal-as-a-metabolic-new-biomarker-of-tumor-cell-proliferation-in-cancers/329591.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the study’s main goal regarding methylglyoxal?","Question",{"text":113,"@type":114},"To assess whether free methylglyoxal can serve as a clinically useful metabolic biomarker reflecting tumor cell proliferation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was free methylglyoxal evaluated in the study?",{"text":118,"@type":114},"Free MG was measured in peripheral blood of cancerous non-diabetic patients and compared with healthy controls and non-cancerous diabetic patients, with additional measurements in tumors and corresponding non-cancer tissues.",{"name":120,"@type":111,"acceptedAnswer":121},"What diagnostic or clinical use is suggested by the results?",{"text":122,"@type":114},"Repeated free MG level measurements could support therapeutic monitoring, and blood-based free MG may help with diagnostic, prognostic, and follow-up purposes in cancers lacking effective biomarkers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},329591,1790193696,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","Article  \nFree Methylglyoxal as a Metabolic New Biomarker of Tumor Cell Proliferation in Cancers  \nDominique Belpomme 1,2, *, Stéphanie Lacomme 3, Clément Poletti 4, Laurent Bonesso 5, Charlotte Hinault-Boyer 5,6, Sylvie Barbier 4 and Philippe Irigaray 2,7  \nCitation: Belpomme, D.; Lacomme, S.; Poletti, C.; Bonesso, L.; Hinault-Boyer, C.; Barbier, S.; Irigaray, P. Free Methylglyoxal as a Metabolic New Biomarker of Tumor Cell Proliferation in Cancers. Cancers 2024, 16, 3922 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers16233922  \nAcademic Editor: Alexandre Escargueil  \nReceived: 24 October 2024  \nRevised: 19 November 2024  \nAccepted: 21 November 2024  \nPublished: 22 November 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Cancer Clinical Research, Paris V University Hospital, 75005 Paris, France  \n2 European Cancer and Environment Research Institute (ECERI), 1000 Brussels, Belgium; [philippei.artac@gmail.com](philippei.artac@gmail.com)  \n3 Centre de Ressources Biologiques, BB-0033-00035, CHRU, 54500 Nancy, France; [s.lacomme@chru-nancy.fr](s.lacomme@chru-nancy.fr)  \n4 Laboratoire Bioavenir, 57000 Metz, France; [clem.poletti@gmail.com](clem.poletti@gmail.com) (C.P.); [sbarbierkittler@icloud.com](sbarbierkittler@icloud.com) (S.B.)  \n5 Clinical Chemistry Laboratory, Pasteur University Hospital, 06000 Nice, France; [bonesso.l@chu-nice.fr](bonesso.l@chu-nice.fr) (L.B.); [hinault-boyer.c@chu-nice.fr](hinault-boyer.c@chu-nice.fr) (C.H.-B.)  \n6 Université Côte d’Azur, INSERM U1065, C3M, 06000 Nice, France  \n7 Association for Research on Treatment Against Cancer (ARTAC), 75015 Paris, France  \n* Correspondence: [contact.belpomme@gmail.com](contact.belpomme@gmail.com); Tel.: +33-(0)145785353  \nSimple Summary: This manuscript describes an innovative biomarker for cancer. Cancer cells often exhibit altered metabolism, known as the Warburg effect, where they preferentially use anaerobic glycolysis even in the presence of oxygen. This leads to increased production of methylglyoxal, aside-product of glycolysis. We demonstrate here for the first time that human tumor cells can produce and release free methylglyoxal at high levels, whereas normal cells do not. Consequently, it appears that, in spite of some limitations, free methylglyoxal can be used as a metabolic new clinically useful biomarker in cancers, including cases for which there is still no available biomarker. Our findings open the way to further bio-clinical developments.  \nAbstract: Background: A fundamental property of cancer cells is their metabolic reprogramming, allowing them to increase glucose uptake and glycolysis. Using a rat colon adenocarcinoma model, we previously showed that blood levels of free methylglyoxal (MG), a side-product of glycolysis, remained normal in animals grafted with a non-growing tumor cell clone, while MG levels were significantly increased and positively correlated with tumor growth in animals grafted with a tumorigenic cell clone issued from the same tumor. Methods: We measured free MG in the blood of cancerous non-diabetic patients and compared the results to healthy subjects and non-cancerous diabetic patients. We also measured free MG in tumors and in the corresponding non-cancer tissues, and the peripheral blood. Results: We show that free MG levels in the peripheral blood of cancer patients are significantly increased in comparison with free MG levels in the peripheral blood of healthy controls (p \u003C 0.0001), and similar to those in the peripheral blood of hyperglycemic diabetic patients (p = 0.965) . In addition, we show that repeated free MG level measurement could be use","cbCaioaqPh7Em9M7","https://ap.wps.com/l/cbCaioaqPh7Em9M7","pdf",1149832,11,"English","# Introduction\n## Background on cancer metabolism and biomarkers\n## Methylglyoxal rationale and study objectives","[{\"question\":\"What is the study’s main goal regarding methylglyoxal?\",\"answer\":\"To assess whether free methylglyoxal can serve as a clinically useful metabolic biomarker reflecting tumor cell proliferation.\"},{\"question\":\"How was free methylglyoxal evaluated in the study?\",\"answer\":\"Free MG was measured in peripheral blood of cancerous non-diabetic patients and compared with healthy controls and non-cancerous diabetic patients, with additional measurements in tumors and corresponding non-cancer tissues.\"},{\"question\":\"What diagnostic or clinical use is suggested by the results?\",\"answer\":\"Repeated free MG level measurements could support therapeutic monitoring, and blood-based free MG may help with diagnostic, prognostic, and follow-up purposes in cancers lacking effective biomarkers.\"}]","Free Methylglyoxal as a Metabolic New Biomarker of Tumor Cell Proliferation in Cancers | PDF",1789984677,28]