[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377902-105":59,"doc-detail-377902-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","foxa1-in-prostate-cancer-review","FOXA1 in prostate cancer - REVIEW","","Review summarizes the interplay of FOXA1-targeted genes, regulators of FOXA1, and FOXA1 functions in prostate cancer, with particular emphasis on androgen receptor (AR). It explains how FOXA1 may contribute to transitions from androgen deprivation therapy–responsive disease to castration-resistant, metastatic, and neuroendocrine prostate cancer. The review also evaluates distinct FOXA1 mutation roles and clinical relevance across disease stages, highlighting FOXA1 as a potential biomarker and therapeutic target.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/foxa1-in-prostate-cancer-review/377902/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/foxa1-in-prostate-cancer-review/377902.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does FOXA1 relate to prostate cancer progression after androgen deprivation therapy?","Question",{"text":113,"@type":114},"The review describes a shift in transcriptional networks during progression to castration-resistant and metastatic states and proposes that FOXA1 may drive this process through multiple mechanisms, especially via androgen receptor function.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What is the role of FOXA1 in prostate development?",{"text":118,"@type":114},"FOXA1 is involved in prostate development by regulating AR transcriptional activity, with evidence that FOXA1 is expressed in epithelial cells rather than stromal cells and supports epithelial maturation and early ductal pattern formation.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are FOXA1 mutations clinically important in prostate cancer?",{"text":122,"@type":114},"The review notes increased FOXA1 mutation frequency in castration-resistant contexts and discusses distinct mutation roles and clinical significance, suggesting potential utility for prognosis and targeted therapy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377902,1790340469,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Prostate Cancer  \nOpen Access  \nREVIEW  \nFOXA1 in prostate cancer  \nHui-Yu Dong1,2,*, Lei Ding1,*, Tian-Ren Zhou1, Tao Yan1, Jie Li1, Chao Liang1  \nMost prostate cancers initially respond to androgen deprivation therapy (ADT) . With the long-term application of ADT, localized prostate cancer will progress to castration-resistant prostate cancer (CRPC), metastatic CRPC (mCRPC), and neuroendocrine prostate cancer (NEPC), and the transcriptional network shifted. Forkhead box protein A1 (FOXA1) may play a key role in this process through multiple mechanisms. To better understand the role of FOXA1 in prostate cancer, we review the interplay among FOXA1-targeted genes, modulators of FOXA1, and FOXA1 with a particular emphasis on androgen receptor (AR) function. Furthermore, we discuss the distinct role of FOXA1 mutations in prostate cancer and clinical significance of FOXA1. We summarize possible regulation pathways of FOXA1 in different stages of prostate cancer. We focus on links between FOXA1 and AR, which may play different roles in various types of prostate cancer. Finally, we discuss FOXA1 mutation and its clinical significance in prostate cancer. FOXA1 regulates the development of prostate cancer through various pathways, and it could be a biomarker for mCRPC and NEPC. Future efforts need to focus on mechanisms underlying mutation of FOXA1 in advanced prostate cancer. We believe that FOXA1 would be a prognostic marker and therapeutic target in prostate cancer.  \nAsian Journal of Andrology (2023) 25 , 287–295; doi: 10.4103/aja202259; published online: 19 August 2022 Keywords: androgen receptor; forkhead box protein A1; mutation; prostate cancer  \nINTRODUCTION  \nProstate cancer is the second leading cause of estimated cancer deaths and accounted for 21% of all cases among men in 2020.1 Prostate cancer has the highest 5-year survival rate for all stages combined among all cancers.1 Although the overall incidence of prostate cancer has declined, distant-stage diagnoses have increased.2 Men diagnosed with primary prostate cancer are usually treated with curative treatment, and more than 30% of patients progress to metastatic disease within 10 years.3,4 Androgen deprivation therapies (ADTs) are then used to treat metastatic disease and have an initial response rate of approximately 80% .5,6 Despite the efficacy of ADT, patients ultimately develop resistance and progress to metastatic castrationresistant prostate cancer (mCRPC).5,7 Notably, Asian patients usually present with higher tumor grades in prostate cancer at diagnosis compared with Western populations.8 Therefore, there remains a need to understand the genomic underpinnings of prostate cancer development.  \nForkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF3A), was first identified as a transcription factor for the expression of transthyretin and α1-antitrypsin inthe liver.9 FOXA1 was found to collaborate with NK2 homeobox 1 (NKX2-1) and functioned as an oncogene in lung cancer.10 Metastasis of pancreatic ductal adenocarcinoma was linked with FOXA1-dependent enhancer reprogramming.11 In the past few years, FOXA1 expression has been reported to be related to several human cancers, as both an oncogene and a tumor suppressor gene depending on the specific cancer types. 12,13 Even in the same type of cancer, FOXA1 can play different roles indifferent subtypes. 14,15  \nRecent findings have shown that FOXA1 plays an important role in regulating steroid receptor functions.16 Prostate cancer and breast cancer are the two most prominent hormone-related tumors, so they are not surprisingly related to FOXA1 . As FOXA1 is obligatory for androgen receptor (AR)-mediated genes for CRPC, it is thought to play an important role in prostate cancer progression.17 Recent studies revealed that the genetic mutation frequency of FOXA1 is increased in mCRPC patients, suggesting that FOXA1 mutations may be a factor leading to aggressive prostate cancer.18,19 FOXA1","cbCairYHIuym1bPW","https://ap.wps.com/l/cbCairYHIuym1bPW","pdf",1010136,"English","# INTRODUCTION\n# FOXA1 in the development of the prostate\n## FOXA1 roles in epithelial and stromal androgen receptor signaling\n# FOXA1 in prostate cancer initiation, progression, and drug resistance\n## FOXA1–AR links and transcriptional network shifts\n## FOXA1 mutations and clinical significance","[{\"question\":\"How does FOXA1 relate to prostate cancer progression after androgen deprivation therapy?\",\"answer\":\"The review describes a shift in transcriptional networks during progression to castration-resistant and metastatic states and proposes that FOXA1 may drive this process through multiple mechanisms, especially via androgen receptor function.\"},{\"question\":\"What is the role of FOXA1 in prostate development?\",\"answer\":\"FOXA1 is involved in prostate development by regulating AR transcriptional activity, with evidence that FOXA1 is expressed in epithelial cells rather than stromal cells and supports epithelial maturation and early ductal pattern formation.\"},{\"question\":\"Why are FOXA1 mutations clinically important in prostate cancer?\",\"answer\":\"The review notes increased FOXA1 mutation frequency in castration-resistant contexts and discusses distinct mutation roles and clinical significance, suggesting potential utility for prognosis and targeted therapy.\"}]","FOXA1 in prostate cancer - REVIEW | PDF",1790227569,23]