[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31907":3,"doc-seo-31907":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31907,687197207639,"Asher","https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd",8,"Research & Report","Formulation Development and Evaluation of Transferosomal Gel","The study develops transfersomal vesicular gel formulations for enhanced transdermal delivery of clindamycin phosphate, addressing limits of conventional topical clindamycin such as low topical bioavailability and local irritation. Acne vulgaris is presented as a multifactorial condition, motivating an optimized anti-acne delivery system. Preformulation work evaluates appearance, solubility, melting point, FT-IR identity, UV λmax determination, calibration, and drug–excipient compatibility. Vesicle size and entrapment efficiency are measured, with formulation T2 selected as optimized for further evaluation based on smallest vesicle size and higher entrapment.","cbCaiqe3fByzDsdD","https://ap.wps.com/l/cbCaiqe3fByzDsdD","pdf",791727,1,10,"English","en","# Introduction\n# Methods\n## Preformulation studies of clindamycin phosphate\n## Compatibility studies\n# Results of Evaluation of transfersomes\n## Microscopic observation\n## Vesicle size and entrapment efficiency","[{\"question\":\"Why are transfersomes of clindamycin phosphate considered for acne treatment?\",\"answer\":\"To overcome topical clindamycin limitations such as low topical bioavailability and irritation, transfersomal formulations are prepared to enhance skin delivery and reduce treatment-related side effects.\"},{\"question\":\"What preformulation parameters were evaluated for clindamycin phosphate?\",\"answer\":\"The work assessed physical appearance, solubility, melting point, FT-IR identity peaks, and UV determination of λmax with a calibration curve at 486 nm.\"},{\"question\":\"How were the transfersomes evaluated and which formulation was selected as optimized?\",\"answer\":\"Prepared transfersomes were examined microscopically for appearance, and vesicle size and entrapment efficiency were quantified. Formulation T2 was selected as optimized due to the smallest vesicle size and increased entrapment efficiency.\"}]",1780434128,25,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"formulation-development-and-evaluation-of-transferosomal-gel","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/formulation-development-and-evaluation-of-transferosomal-gel/31907/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-06-02",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"Why are transfersomes of clindamycin phosphate considered for acne treatment?","Question",{"text":73,"@type":74},"To overcome topical clindamycin limitations such as low topical bioavailability and irritation, transfersomal formulations are prepared to enhance skin delivery and reduce treatment-related side effects.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"What preformulation parameters were evaluated for clindamycin phosphate?",{"text":78,"@type":74},"The work assessed physical appearance, solubility, melting point, FT-IR identity peaks, and UV determination of λmax with a calibration curve at 486 nm.",{"name":80,"@type":71,"acceptedAnswer":81},"How were the transfersomes evaluated and which formulation was selected as optimized?",{"text":82,"@type":74},"Prepared transfersomes were examined microscopically for appearance, and vesicle size and entrapment efficiency were quantified. Formulation T2 was selected as optimized due to the smallest vesicle size and increased entrapment efficiency.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]