[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-403325-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-403325-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","for-health-care-providers-what-you-need-to-know-about-hiv-prep","For Health Care Providers - What you need to know about HIV PrEP","","PrEP (pre-exposure prophylaxis) helps HIV-negative individuals reduce the risk of acquiring HIV through daily or event-driven oral ART before and after potential exposure. The brochure explains the TDF/FTC combination, how consistent use lowers HIV acquisition risk by over 90%, and guidance on starting timelines to reach protective levels. It outlines dosing instructions, missed-dose and vomiting scenarios, key contraindications, interaction and renal/bone cautions, and counsel to continue condom use during initiation.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/for-health-care-providers-what-you-need-to-know-about-hiv-prep/403325/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/for-health-care-providers-what-you-need-to-know-about-hiv-prep/403325.png","ImageObject",300,407,{"name":42,"@type":43},"Maya Linwood","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-27",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does PrEP stand for and how does it reduce HIV risk?","Question",{"text":63,"@type":64},"PrEP stands for pre-exposure prophylaxis. It uses daily (or on-demand) oral antiretroviral therapy by HIV-negative individuals to reduce the risk of acquiring HIV before and after potential exposure.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How effective is HIV PrEP when taken consistently?",{"text":68,"@type":64},"When taken consistently, HIV PrEP reduces the risk of acquiring HIV by over 90%.",{"name":70,"@type":61,"acceptedAnswer":71},"What should clinicians tell patients about missed doses?",{"text":72,"@type":64},"If a dose is missed but remembered within 12 hours, take it as soon as possible and resume the usual schedule. If missed by more than 12 hours and it is almost time for the next dose, do not take the missed dose—resume the normal dosing schedule.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},403325,1790984004,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":123,"preview_page_count":4},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","For Health Care Providers  \nWhat you need to know about HIV PrEP  \nPrEP stands for pre-exposure prophylaxis. It is the use of daily (or ondemand) oral antiretroviral therapy (ART) by HIV-negative individuals to reduce the risk of acquiring HIV. HIV PrEP refers to ongoing use of ART before and after potential exposure to HIV.  \nHIV PrEP involves taking the combination medication tenofovirdisoproxil fumarate/emtricitabine 300/200 mg (eg. TDF/FTC; brand name Truvada) . These two drugs are part of the nucleoside reverse transcriptase inhibitor (NRTI) class of drugs, and work by blocking HIV reverse transcription, thereby preventing the construction of new proviral DNA.  \nEffectiveness  \nWhen taken consistently, PrEP has been shown to reduce the risk of acquiring HIV by over 90% .  \nStarting HIV PrEP  \nTime is needed to build up protective levels of PrEP within the body.  \nThe time from initiation of daily oral doses of HIV PrEP to maximal protection against HIV acquisition is uncertain. However, pharmacokinetic data from individuals living with HIV suggest that steady-state levels in the rectal mucosa are reached  \nafter 7 days; in the cervico-vaginal mucosa, this occurs after 21 days following therapy initiation.  \nIndividuals should be counselled to continue condom use during this period.  \nTaking HIV PrEP  \nHIV PrEP tablets can be taken any time of day, with or without food. PrEP is taken as one tablet once a day. It does not have to be taken at the same time each day, though those taking PrEP  \nshould be counselled to try taking it at roughly the same time every day. This usually helps people remember to take it.  \nContraindications and Cautions  \nAny previously demonstrated hypersensitivity to any components of the medication is a contraindication to its use. For a complete listing, see the DOSAGE FORMS, COMPOSITION AND PACKAGING section of the Product Monograph.  \nPeople who already have HIV should not take HIV PrEP; they should be offered antiretroviral therapy.  \nDo not initiate HIV PrEP if signs or symptoms of acute HIV infection are present, and/or there is clinical suspicion of acute HIV. Speak to an infectious diseases or HIV expert if you are unsure.  \nAlthough it is safe to take PrEP with many other medications, it is important to check for drug interactions and/or overlapping toxicities between TDF/FTC and other medications being taken concurrently. Since TDFis primarily renally eliminated, there is a potential for increased nephrotoxicity with other agents that can affect renal function, including non-steroidal anti-inflammatory drugs (NSAIDS) . Consider alternatives to NSAIDS inpatients taking TDF and at risk of renal impairment.  \nAs TDF has been associated with decreases in bone mineral density in both HIV treatment and HIV PrEP settings, it should be used with caution in persons with  \n1  \na history of osteoporosis or osteomalacia, and fragility fractures. At present, no specific bone mineral density screening is recommended before or during HIV PrEP use, though individuals on PrEP should be counselled to take bone-protective measures (eg. vitamin Dsupplementation, weight-bearing exercise) .  \nIntermittent or On-Demand use of HIV-PrEP  \nThis is considered off-label use; the use of daily HIV PrEP is advised for maximal protection if an individual is having ongoing sex over undefined periods of time. For individuals in whom intermittent or on-demand (i.e. event-driven) PrEP use is seen as appropriate, there maybe two dosing strategies recommended:  \n• Discrete periods of use (intermittent)*  \n- Start 7 days prior to anticipated time of sexual activity for rectal exposures, or 21 days for vaginal exposures;  \n- Continue PrEP for one month after last risk exposure  \n* This is extrapolated from daily use, and has not been fully evaluated in clinical trials.  \n• As per the Ipergay trial of on demand (event-driven) PrEP use*  \n- Take a loading dose of 2 tablets, 2-24 hrs before anticipated sex, then if sex happens:  \n","cbCain0TkSmkqlmT","https://ap.wps.com/l/cbCain0TkSmkqlmT","pdf",732556,"English","# Effectiveness\n# Starting HIV PrEP\n# Taking HIV PrEP\n# Contraindications and Cautions\n# Intermittent or On-Demand Use of HIV-PrEP\n# Missed Doses\n# What if a Dose is Vomited?\n# Drugs, Medications and Hormones","[{\"question\":\"What does PrEP stand for and how does it reduce HIV risk?\",\"answer\":\"PrEP stands for pre-exposure prophylaxis. It uses daily (or on-demand) oral antiretroviral therapy by HIV-negative individuals to reduce the risk of acquiring HIV before and after potential exposure.\"},{\"question\":\"How effective is HIV PrEP when taken consistently?\",\"answer\":\"When taken consistently, HIV PrEP reduces the risk of acquiring HIV by over 90%.\"},{\"question\":\"What should clinicians tell patients about missed doses?\",\"answer\":\"If a dose is missed but remembered within 12 hours, take it as soon as possible and resume the usual schedule. If missed by more than 12 hours and it is almost time for the next dose, do not take the missed dose—resume the normal dosing schedule.\"}]","For Health Care Providers - What you need to know about HIV PrEP | PDF",1790538898]