[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-308809-105":59,"doc-detail-308809-en":122},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":115,"head_meta":117,"extra_data":119,"updated_unix":121},105,"en","food-seeking-behavior-is-triggered-by-skin-ultraviolet-exposure-in-males-key-findings-and-mechanisms","Food-seeking behavior is triggered by skin ultraviolet exposure in males - Key findings and mechanisms","","Sexual dimorphisms shape metabolic and behavioral outcomes, but the effects of solar ultraviolet (UV) exposure on male versus female physiology remain unclear. Evidence from epidemiology (~3,000 individuals) shows that solar exposure increases food-seeking and food intake in men, not women. In mice, UVB enhances food-seeking, intake, and weight gain with male-biased responses. Circulating ghrelin rises alongside appetite, driven by UVB-induced p53 activation in skin adipocytes; p53 loss prevents these effects. In females, estrogen disrupts p53-chromatin interaction at the ghrelin promoter, blocking ghrelin and UVB-triggered feeding, highlighting skin as an energy-homeostasis mediator.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/food-seeking-behavior-is-triggered-by-skin-ultraviolet-exposure-in-males-key-findings-and-mechanisms/308809/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/food-seeking-behavior-is-triggered-by-skin-ultraviolet-exposure-in-males-key-findings-and-mechanisms/308809.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-20",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"How do p53 and estrogen determine the sex-specific response to UVB?","Question",{"text":112,"@type":113},"UVB irradiation activates p53 transcription of ghrelin in skin adipocytes, and a conditional p53 knockout abolishes UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53–chromatin interaction on the ghrelin promoter, blocking ghrelin and UVB-triggered food-seeking behavior.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},308809,1789991202,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":131,"language":132,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":67,"update_tm":136,"read_time":137},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","Articles  \n[https://doi.org/10.1038/s42255-022-00587-9](https://doi.org/10.1038/s42255-022-00587-9)  \nFood-seeking behavior is triggered by skin ultraviolet exposure in males  \nShivang Parikh 1, Roma Parikh1, Keren Michael 2, Lior Bikovski3,4, Georgina Barnabas1,  \nMariya Mardamshina1, Rina Hemi5, Paulee Manich 1, Nir Goldstein6, Hagar Malcov-Brog1, Tom Ben-Dov 1,7, Ohad Glaich1, Daphna Liber1, Yael Bornstein6, Koral Goltseker 8, Roy Ben-Bezalel9, Mor Pavlovsky10, Tamar Golan1, Liron Spitzer 10, Hagit Matz10,11,12, Pinchas Gonen1, Ruth Percik 12,13, Lior Leibou14, Tomer Perluk14, Gil Ast1, Jacob Frand14, Ronen Brenner15, Tamar Ziv 16, Mehdi Khaled17, Shamgar Ben-Eliyahu18,19, Segev Barak 18,19, Orit Karnieli-Miller 20, Eran Levin9, Yftach Gepner 6, Ram Weiss21, Paul Pfluger 22, Aron Weller 23 and Carmit Levy 1 ✉  \nSexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males and females react differently to environmental cues, such as solar ultraviolet (UV) exposure, is unknown. Here we show that solar exposure induces food-seeking behavior, food intake, and food-seeking behavior and food intake in men, but not in women, through epidemiological evidence of approximately 3,000 individuals throughout the year. In mice, UVB exposure leads to increased food-seeking behavior, food intake and weight gain, with a sexual dimorphism towards males. In both mice and human males, increased appetite is correlated with elevated levels of circulating ghrelin. Specifically, UVB irradiation leads to p53 transcriptional activation of ghrelin in skin adipocytes, while a conditional p53-knockout in mice abolishes UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53–chromatin interaction on the ghrelin promoter, thus blocking ghrelin and food-seeking behavior in response to UVB exposure. These results identify the skin as a major mediator of energy homeostasis and may lead to therapeutic opportunities for sex-based treatments of endocrine-related diseases.  \nS  \nex differences have profound effects on health and behavior1. Yet, whether men and women react differently to environmental cues, such as ultraviolet (UV) radiation,  \nremains under investigated. UV was recognized as a carcinogen in 1928 (ref. 2), sparking a massive cultural trend of minimizing exposure to the sun from the mid-1900s2. But subsequent epidemiological studies have painted a more complex picture of UV’s role in human health, by indicating that it can extend life expectancy, due to protection against cardiovascular disease and other causes of mortality2. Sun exposure increase liver metabolism, protecting the organ from hepatocellular lipotoxicity3 and metabolic disease3.  \nThe solar radiation’s health benefits have been attributed to vitamin D4. But two recent large-scale clinical trials showed that vitamin D alone was not associated with reduced risk of cardiovascular  \ndisease, all-cause mortality and invasive cancer4. These findings indicate that at least some of the health benefits of sunlight are independent of vitamin D.  \nThe skin is the largest organ in the human body and is the first line of defense against environmental threats. Its epidermal and dermal layers are separated by a basal epidermal layer composed of undifferentiated, self-renewing keratinocytes and melanocytes. The dermis includes fibroblasts and blood vessels, with the hypodermis mainly consisting of adipocytes5. The skin is a dermato-endocrine organ, with its resident cells, featuring multiple hormone receptors6. With the exception of β-endorphin7, vitamin D and estrogen, production and release of hormones from skin cells into the blood has not been documented, nor are the triggers for such activities (reviewed elsewhere6) or their potential systemic effect on body physiology known.  \n1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 2Departmen","cbCaipZ4V3iBCmPz","https://ap.wps.com/l/cbCaipZ4V3iBCmPz","pdf",21856257,38,"English","# Introduction\n## Sex differences and ultraviolet exposure\n# Methods and evidence\n## Epidemiological observations\n## Mouse UVB experiments\n# Results\n## UV-induced feeding behavior in men\n## Ghrelin and p53 mechanism in skin adipocytes\n## Estrogen blockade in females\n# Conclusions and implications\n## Skin as a mediator of energy homeostasis","[{\"question\":\"How do p53 and estrogen determine the sex-specific response to UVB?\",\"answer\":\"UVB irradiation activates p53 transcription of ghrelin in skin adipocytes, and a conditional p53 knockout abolishes UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53–chromatin interaction on the ghrelin promoter, blocking ghrelin and UVB-triggered food-seeking behavior.\"}]","Food-seeking behavior is triggered by skin ultraviolet exposure in males - Key findings and mechanisms | PDF",1789872453,96]