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A review of systematic reviews and meta-analyses up to February 2024 evaluated associations between folate status (diet, supplements, or blood levels) and cancer outcomes, applying duplicate screening, extraction, and bias assessment. Sixty-seven syntheses were identified, with highly suggestive credibility signals for oesophageal, colorectal, childhood brain and spinal tumors, and total cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/folate-and-global-health-umbrella-review-series-part-2-syntheses-on-cancers/346502/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/folate-and-global-health-umbrella-review-series-part-2-syntheses-on-cancers/346502.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of the umbrella review on folate and global health?","Question",{"text":112,"@type":113},"To synthesize evidence from systematic reviews and meta-analyses on associations between folate status and specific cancer outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were studies identified and assessed in the review?",{"text":117,"@type":113},"Searches covered MEDLINE, Embase, CINAHL, Cochrane Library, and DARE up to February 2024, with duplicate screening, data extraction, and risk-of-bias assessment.",{"name":119,"@type":110,"acceptedAnswer":120},"Which cancer-related associations were reported as highly suggestive?",{"text":121,"@type":113},"Highly suggestive credibility was found for oesophageal, colorectal, childhood brain and spinal tumours, and total cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},346502,1790174229,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Electronic supplementary material:  \nThe online version of this article contains supplementary material.  \n© 2026 The Author(s)  \nCite as: Yoo S, Montazeri A, Bennett D, Bo Y, Chen P, Duthie S, Jensen N, Kaminga A, Lai J, Li X, MacFarlane AJ, Martinez H, McNulty H, Momoli F, Mossey P, Mullie P, Munger R, Parajuli RP, Kent MP, Rubini M, Senekal M, Sikora L, Stintzi A, Theodoratou E, Wang H, Yajnik C, Yaktine A, Little J. Folate and global health umbrella review series, part 2: syntheses on cancers. J Glob Health. 2026;16:04102 .  \nFolate and global health umbrella review series, part 2: syntheses on cancers  \nSamantha Yoo1, Azita Montazeri1, Derrick Bennett2, Yacong Bo3, Peizhan Chen4, Susan Duthie5, Natalie Jensen1, Atipatsa Kaminga6, Jun-Shi Lai7, Xue Li8, Amanda J MacFarlane9, Homero Martinez10, Helene McNulty11, Franco Momoli1, Peter Mossey12, Patrick Mullie13, Ron Munger14, Rajendra Prasad Parajuli15, Monique Potvin Kent1, Michele Rubini16, Marjanne Senekal17, Lindsey Sikora1,  \nAlain Stintzi18, Evropi Theodoratou19, Hui Wang20, Chittaranjan Yajnik21, Ann Yaktine22, Julian Little1  \n1School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Canada 2 Division of Medical Sciences, Division of Population Health, University of Oxford, UK 3School of Public Health, Xinxiang Medical University, China  \n4Clinical Research Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 5School of Pharmacy and Life Sciences, Robert Gordon University, Scotland, UK  \n6 Department of Mathematics and Statistics, Faculty of Science, Technology and Innovation, Mzuzu University, Malawi 7Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore  \n8Centre for Population Health Sciences, University of Edinburgh, UK 9 Nutrition Research Division, Health Canada, Canada  \n10 Research and Development Unit, Nutrition International, Canada  \n11 Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK 12School of Dentistry, University of Dundee, Scotland, UK  \n13 International Prevention Research Institute, Lyon, France  \n14 Department of Nutrition, Dietetics, and Food Sciences, College of Agriculture and Applied Sciences, Utah State University, USA 15 Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, USA 16 Department of Neuroscience and Rehabilitation, University of Ferrara, Italy  \n17 Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa 18School of Pharmacy, Faculty of Medicine, University of Ottawa, Canada  \n19Centre for Global Health, Usher Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, UK 20School of Public Health, Faculty of Medicine, Shanghai Jiao Tong University, China  \n21 Diabetes Unit, KEM Hospital Research Centre, India  \n22 Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine, USA  \nCorrespondence to:  \nJulian Little  \nSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa 600 Peter Morand Crescent, Ottawa, Ontario, K1G 5Z3  \nCanada  \n[jlittle@uottawa.ca](jlittle@uottawa.ca)  \nPAPERS  \nYoo et al.  \n\n| \u003Cbr>Background Folate has been examined extensively in relation to carcinogenesis due to its role in one-carbon metabolism impacting the synthesis of DNA and RNA, methylation processes, and genomic integrity. Current evidence on the relationship between folate status and the risk of cancer is equivocal: low or deficient folate status may contribute to an increased risk of cancers, while high-dose folic acid supplementation may have adverse effects on carcinogenesis .\u003Cbr>Methods We searched MEDLINE, Embase, CINAHL, the Cochrane Library, and the Database of Abstracts of Reviews of Effects up to February 2024 for systematic reviews and meta-analyses investiga","cbCairK6ZE0pnQsK","https://ap.wps.com/l/cbCairK6ZE0pnQsK","pdf",749037,"English","# Background\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What is the purpose of the umbrella review on folate and global health?\",\"answer\":\"To synthesize evidence from systematic reviews and meta-analyses on associations between folate status and specific cancer outcomes.\"},{\"question\":\"How were studies identified and assessed in the review?\",\"answer\":\"Searches covered MEDLINE, Embase, CINAHL, Cochrane Library, and DARE up to February 2024, with duplicate screening, data extraction, and risk-of-bias assessment.\"},{\"question\":\"Which cancer-related associations were reported as highly suggestive?\",\"answer\":\"Highly suggestive credibility was found for oesophageal, colorectal, childhood brain and spinal tumours, and total cancers.\"}]","Folate and global health umbrella review series, part 2 - syntheses on cancers | PDF",1790061733,48]