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The lesion was peripheral in the right upper lobe and measured 11 mm. With a history of metachronous prostate and gastric cancers, the case underwent CT-assisted percutaneous needle biopsy. Histology and immunohistochemistry supported metastatic prostate carcinoma, rather than primary lung cancer, and disease stability persisted for 4 months.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/focal-ground-glass-opacity-of-the-lung-in-metachronous-prostate-and-gastric-cancer-a-case-report/337921/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/focal-ground-glass-opacity-of-the-lung-in-metachronous-prostate-and-gastric-cancer-a-case-report/337921.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What did chest CT show in this case?","Question",{"text":113,"@type":114},"Chest CT revealed a focal ground glass opacity (GGO) with a minimal solid area in the peripheral right upper lobe, measuring 11 mm.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why was biopsy performed instead of relying on imaging alone?",{"text":118,"@type":114},"Because focal GGO can be caused by interstitial fibrosis, inflammation, or primary lung adenocarcinoma, and the patient had prior malignancy history, pathological assessment was necessary to distinguish primary from metastatic disease.",{"name":120,"@type":111,"acceptedAnswer":121},"What key immunohistochemical findings supported the final diagnosis?",{"text":122,"@type":114},"The carcinoma cells were negative for markers including CK7, CK20, TTF-1, and CDX2, but positive for prostate-specific antigen and P504S, leading to a diagnosis of metastatic carcinoma from prostate cancer.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},337921,1790440812,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","MOLECULAR AND CLINICAL ONCOLOGY 21: 54, 2024  \nFocal ground glass opacity of the lung in metachronous prostate and gastric cancer: A case report  \nRYUICHI WADA 1 , TOMOHIKO YAMAMOTO 1 , KENICHI IWASAKI2 , SHINSUKE USUI2 , NOBUAKI MATSUBARA3 and HIROAKI NOMORI4  \n1Department of Diagnostic Pathology, Kashiwa Kousei General Hospital, Kashiwa, Chiba 277‑8551, Japan;  \n2Department of Surgery, Kashiwa Kousei General Hospital, Kashiwa, Chiba 277‑8551, Japan; 3Department of Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277‑8577, Japan; 4Department of Thoracic Surgery, Kashiwa Kousei General Hospital, Kashiwa, Chiba 277‑8551, Japan  \nReceived April 6, 2024; Accepted May 31, 2024  \nDOI: 10. 3892/mco.2024.2752  \nAbstract. Chest computed tomography (CT) revealed a focal ground glass opacity (GGO) with a minimal solid area in a 75‑year‑old man. The shadow was located in the periphery of the right upper lobe and measured 11 mm in diameter. The patient had a medical history of metachronous prostate and gastric cancers. The patient had been treated with androgen deprivation therapy for prostate cancer for 12 years and under‑ went subtotal gastrectomy for triple gastric cancers 7 months before. Since primary lung adenocarcinoma was suspected, CT‑assisted percutaneous needle biopsy was performed. Histology revealed the sheet‑like and trabecular proliferation of atypical cells, suggesting that the lesion was moderately to poorly differentiated adenocarcinoma . Adenocarcinoma cells showed subepithelial extension causing the thickening of alveolar walls . A tumor thrombus was not detected in the blood or lymphatic vessels. Immunohistochemistry revealed that carcinoma cells were negative for cytokeratin 7 (CK7), CK20, thyroid transcription factor‑1 and CDX2 and positive for prostate‑specific antigen and P504S. Based on these findings, the patient was diagnosed with metastatic carcinoma from prostate cancer. The disease remained stable for 4 months after the diagnosis, and no new lesions were  \nCorrespondence to: Dr Ryuichi Wada, Department of Diagnostic Pathology, Kashiwa Kousei General Hospital, 617 Shikoda, Kashiwa, Chiba 277‑8551, Japan  \nE‑mail: [ryuichi.kkgh@gmail.com](ryuichi.kkgh@gmail.com)  \nAbbreviations: ADT, androgen deprivation therapy; CK, cytokeratin; CT, computed tomography; FDP, fibrinogen degradation products; GGO, ground glass opacity; IHC, immunohistochemistry; PSA, prostate‑specific antigen; PTTM, pulmonary tumor thrombotic microangiopathy; TTF1, thyroid transcription factor‑1  \nKey words: prostate‑specific antigen, thyroid transcription factor‑1, CDX2, lymphangitic carcinomatosis, pulmonary tumor thrombotic microangiopathy  \nobserved on chest CT. Metastatic carcinoma rarely presents with focal GGO. Lung biopsy is necessary to identify the pathology of the lesion, and the primary site needs to be confirmed by immunohistochemistry with specific markers, particularly in a case of metachronous multiple cancers. A tumor thrombus, which is suggestive of lymphangitic carci‑ nomatosis or pulmonary tumor thrombotic microangiopathy, also needs to be evaluated.  \nIntroduction  \nMetastatic carcinoma in the lung generally presents with multiple nodular shadows. Metastatic carcinoma may present with ground glass opacity (GGO), usually with diffuse form, on chest computed tomography (CT) . Diffuse GGO represents lymphatic and/or vascular spread of carcinoma in the lung (1) . Focal GGO, which is localized or nodular form on chest CT, is uncommon in metastatic carcinoma . Since various lung diseases such as interstitial fibrosis, inflammation and primary lung adenocarcinoma present with GGO, it is difficult to reach an accurate diagnosis based solely on radiological findings. Thus, in a case with past history of carcinoma, pathological assessment of focal GGO by biopsy or partial resection is necessary to determine whether the lesion is primary or metastatic carcinoma. The assessment is also critical to decide appropria","cbCaipW4ISQfGSMH","https://ap.wps.com/l/cbCaipW4ISQfGSMH","pdf",3727196,"English","# Abstract\n# Introduction\n# Case report\n## Patient history\n## Diagnostic workup and pathology\n## Diagnosis and clinical course","[{\"question\":\"What did chest CT show in this case?\",\"answer\":\"Chest CT revealed a focal ground glass opacity (GGO) with a minimal solid area in the peripheral right upper lobe, measuring 11 mm.\"},{\"question\":\"Why was biopsy performed instead of relying on imaging alone?\",\"answer\":\"Because focal GGO can be caused by interstitial fibrosis, inflammation, or primary lung adenocarcinoma, and the patient had prior malignancy history, pathological assessment was necessary to distinguish primary from metastatic disease.\"},{\"question\":\"What key immunohistochemical findings supported the final diagnosis?\",\"answer\":\"The carcinoma cells were negative for markers including CK7, CK20, TTF-1, and CDX2, but positive for prostate-specific antigen and P504S, leading to a diagnosis of metastatic carcinoma from prostate cancer.\"}]","Focal ground glass opacity of the lung in metachronous prostate and gastric cancer - A case report | PDF",1790021182,13]