[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-449461-en":59,"doc-seo-449461-105":80},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":72,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":52},449461,962090769181,"Rainbow Cat","https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Focal facial dermal dysplasia type IV - a case series","Focal facial dermal dysplasias (FFDDs) are four rare inherited disorders with skin manifestations in temporal and preauricular regions. Types I–III show bitemporal scar-like lesions from birth, whereas FFDD IV presents analogous lesions localized to the periauricular area. Most FFDD IV cases demonstrate autosomal-recessive inheritance with CYP26C1 mutations. The report describes three infants with bilateral, oval-shaped, hypopigmented preauricular lesions and highlights the need for early recognition to enable accurate diagnosis and exclude associated malformations.","Dermatology Reports 2025; volume 17:10199  \nFocal facial dermal dysplasia type IV: a case series  \nLaura Gnesotto,1-3 Mario Cutrone,4 Giuseppe Ruggiero,5 Carla Morando,6 Anna Belloni Fortina,1,2 Annalisa Patrizi,7 Luigi Naldi,8 Andrea Sechi9  \n1Dermatology Unit, Department of Medicine, University of Padua; 2Pediatric Dermatology Regional Center, Department of Women’sand Children’s Health, University of Padua; 3Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IRCCS, Padua; 4Pediatric Dermatology, Dell’Angelo Hospital, Venice; 5Dermatology Study Group of the Italian Federation of Pediatricians, Rome; 6Neonatal Intensive Care Unit, Department of Pediatrics, San Bortolo Hospital, Vicenza; 7Department of Experimental, Diagnostic and Specialty Medicine, Dermatology, IRCCS Policlinico Di Sant’Orsola, Alma Mater Studiorum University of Bologna; 8Dermatology Unit, San Bortolo Hospital, Vicenza; 9Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy  \nAbstract  \nFocal facial dermal dysplasias (FFDDs) encompass four rare inherited disorders. FFDD types I, II, and III are characterized by bitemporal scar-like lesions present from birth, while FFDD IV is identified by analogous lesions localized in the periauricular area. Most FFDD IV cases show autosomal-recessive inheritance with mutations in the CYP26C1 gene. We describe three infants with bilateral, oval-shaped, hypopigmented preauricular lesions indica-  \nCorrespondence: Andrea Sechi, MD, PhD, Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.  \nE-mail: [andrea.sechi@policlinico.mi.it](andrea.sechi@policlinico.mi.it)  \nKey words: pediatric dermatology; rare diseases; skin signs of systemic disease.  \nConflict of interest: the authors have no conflict of interest to declare.  \nEthics approval and consent to participate: no ethics committee approval was required for this case report according to institutional policy. Informed consent was obtained from the patients’ relatives.  \nConsent for publication: informed consent was obtained from legally authorized representatives for anonymized patient information tobe published in this article.  \nAvailability of data and materials: all data underlying the findings are fully available.  \nReceived: 24 November 2024.  \nAccepted: 27 March 2025.  \nThis work is licensed under a Creative Commons AttributionNonCommercial 4.0 International License (CC BY-NC 4.0) .  \n©Copyright: the Author(s), 2025  \nLicensee PAGEPress, Italy Dermatology Reports 2025; 17:10199 doi:10.4081/dr.2025.10199  \nPublisher's note: all claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and thereviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.  \ntive of FFDD IV. It is crucial for physicians to recognize these rare conditions at an early stage to ensure proper diagnosis and to rule out associated malformations.  \nIntroduction  \nFocal facial dermal dysplasias (FFDDs) are developmental defects presenting with skin lesions in temporal or preauricular areas, similar to aplasia cutis congenita (ACC) . It has been postulated that defects in FFDDs result from the incomplete closure of the ectoderm along facial embryonic fusion lines.1 These skin defects manifest with temporal lesions situated at the junction between the frontonasal and maxillary facial prominences and preauricular lesions at the confluence of maxillary and mandibular prominences.2 Consistent histologic abnormalities have been observed: atrophy and flattening of the epidermis, replacement of the dermis by loose connective tissue, reduced elastic tissue with fragmented fibers, and absence of the subcutaneous tissues and adnexal structures.3,4 Histologic examination of FFDD lesions sh","cbCaiab9MCleRQQC","https://ap.wps.com/l/cbCaiab9MCleRQQC","pdf",4557379,3,"English","en",105,"# Abstract\n# Introduction\n# Case Report","[{\"question\":\"What distinguishes FFDD type IV from other FFDD types?\",\"answer\":\"FFDD IV is identified by analogous lesions localized in the periauricular area, while types I–III typically show bitemporal scar-like lesions from birth.\"},{\"question\":\"What genetic mechanism is most commonly associated with FFDD type IV?\",\"answer\":\"Most FFDD IV cases show autosomal-recessive inheritance with mutations in the CYP26C1 gene.\"},{\"question\":\"Why is early recognition of FFDD IV important in clinical practice?\",\"answer\":\"Early recognition supports proper diagnosis and helps rule out associated malformations that may be linked to these rare conditions.\"}]","Focal facial dermal dysplasia type IV - a case series | PDF",1790730283,{"code":4,"msg":81,"data":82},"ok",{"site_id":75,"language":74,"slug":83,"title":65,"keywords":84,"description":66,"schema_data":85,"social_meta":138,"head_meta":140,"extra_data":142,"updated_unix":143},"focal-facial-dermal-dysplasia-type-iv-a-case-series","",{"@graph":86,"@context":137},[87,100,120],{"@type":88,"itemListElement":89},"BreadcrumbList",[90,94,96,98],{"item":91,"name":92,"@type":93,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":95,"name":9,"@type":93,"position":14},"https://docshare.wps.com/document/",{"item":97,"name":35,"@type":93,"position":72},"https://docshare.wps.com/document/healthcare/",{"item":99,"name":65,"@type":93,"position":19},"https://docshare.wps.com/document/focal-facial-dermal-dysplasia-type-iv-a-case-series/449461/",{"url":99,"name":65,"@type":101,"image":102,"author":107,"headline":65,"publisher":109,"fileFormat":112,"inLanguage":74,"description":66,"dateModified":113,"datePublished":114,"encodingFormat":112,"isAccessibleForFree":115,"interactionStatistic":116},"DigitalDocument",{"url":103,"@type":104,"width":105,"height":106},"https://docshare.wps.com/thumbnails/focal-facial-dermal-dysplasia-type-iv-a-case-series/449461.png","ImageObject",300,407,{"name":63,"@type":108},"Person",{"url":91,"name":110,"@type":111},"DocShare","Organization","application/pdf","2026-10-06","2026-09-30",true,{"@type":117,"interactionType":118,"userInteractionCount":72},"InteractionCounter",{"@type":119},"ViewAction",{"@type":121,"mainEntity":122},"FAQPage",[123,129,133],{"name":124,"@type":125,"acceptedAnswer":126},"What distinguishes FFDD type IV from other FFDD types?","Question",{"text":127,"@type":128},"FFDD IV is identified by analogous lesions localized in the periauricular area, while types I–III typically show bitemporal scar-like lesions from birth.","Answer",{"name":130,"@type":125,"acceptedAnswer":131},"What genetic mechanism is most commonly associated with FFDD type IV?",{"text":132,"@type":128},"Most FFDD IV cases show autosomal-recessive inheritance with mutations in the CYP26C1 gene.",{"name":134,"@type":125,"acceptedAnswer":135},"Why is early recognition of FFDD IV important in clinical practice?",{"text":136,"@type":128},"Early recognition supports proper diagnosis and helps rule out associated malformations that may be linked to these rare conditions.","https://schema.org",{"og:url":99,"og:type":139,"og:title":65,"og:site_name":110,"og:description":66},"article",{"robots":141,"canonical":99},"index,follow",{"doc_id":61,"site_id":75},1791036088]