[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-9970":3,"doc-seo-9970":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":19,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"table_of_contents":24,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},9970,2336464648322,"Aria","https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488",8,"Research & Report","Fluorescent Nanoparticle Drug Delivery System Based on Polymer-Silicon Materials and Its Synergistic Effects in Osteoarthritis","Osteoarthritis treatment is limited by insufficient targeting of underlying disease mechanisms. A multifunctional fluorescent nanoparticle drug delivery system (PMES-TO@1@POM) was developed by functionalizing 3-carboxypropyltriethoxysilane with thiazole orange to enhance targeting and fluorescence for delivering the OA drug Pomalidomide, with composite characterization by FT-IR, DSC, UV-Vis, and fluorescence. The system showed high loading, physiological stability, and pH-responsive release (up to 79% in 12 h at pH 5.8). In an IL-1β-induced OA model, the combination reduced key collagenase expression more than POM alone, indicating improved therapeutic efficacy.","cbCaih8TIuDGdf4K","https://ap.wps.com/l/cbCaih8TIuDGdf4K","pdf",1397093,14,1,9,"English","en","",1776362521,23,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":23,"slug":31,"title":13,"keywords":24,"description":14,"schema_data":32,"social_meta":67,"head_meta":70,"extra_data":72,"updated_unix":25},105,"fluorescent-nanoparticle-drug-delivery-system-based-on-polymer-silicon-materials-and-its-synergistic-effects-in-osteoarthritis",{"@graph":33,"@context":66},[34,51],{"@type":35,"itemListElement":36},"BreadcrumbList",[37,41,45,48],{"item":38,"name":39,"@type":40,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":42,"name":43,"@type":40,"position":44},"https://docshare.wps.com/document/","Document",2,{"item":46,"name":12,"@type":40,"position":47},"https://docshare.wps.com/document/research-report/",3,{"item":49,"name":13,"@type":40,"position":50},"https://docshare.wps.com/document/fluorescent-nanoparticle-drug-delivery-system-based-on-polymer-silicon-materials-and-its-synergistic-effects-in-osteoarthritis/9970/",4,{"url":49,"name":13,"@type":52,"author":53,"headline":13,"publisher":55,"fileFormat":58,"description":14,"dateModified":59,"datePublished":60,"encodingFormat":58,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":54},"Person",{"url":38,"name":56,"@type":57},"DocShare","Organization","application/pdf","2026-06-02","2026-04-16",true,{"@type":63,"interactionType":64,"userInteractionCount":19},"InteractionCounter",{"@type":65},"ViewAction","https://schema.org",{"og:url":68,"og:type":69,"og:title":13,"og:site_name":56,"og:description":14},"https://docshare.wps.com/document/fluorescent-nanoparticle-drug-delivery-system-based-on-polymer-silicon-materials-and-its-synergistic-effects-in-osteoarthritis/9970","article",{"robots":71,"canonical":68},"index,follow",{"doc_id":7,"site_id":30}]