[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-409127-105":59,"doc-detail-409127-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","first-person-marinus-thein","First Person - Marinus Thein","","First Person presents an interview with Marinus Thein, the first author of a Biology Open study on how microtubule (de)tyrosination influences the morphology and motility of Trypanosoma brucei and relates to polyglutamylation. The interview describes his scientific pathway from an early interest in natural sciences to graduate training in Klaus Ersfeld’s lab. It explains the paper’s key message: microtubule protein modifications are interconnected and mutually dependent, shaping cytoskeletal regulation. He highlights rewarding cross-talk observations, values early-career curiosity, and shares advice on incremental scientific progress while outlining his next steps toward an international internship and PhD completion.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":15,"@type":76,"position":81},"https://docshare.wps.com/document/literature/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/first-person-marinus-thein/409127/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/first-person-marinus-thein/409127.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is Marinus Thein researching in his current work?","Question",{"text":112,"@type":113},"He studies how the highly stable microtubule cytoskeleton of Trypanosoma brucei is regulated, focusing on the dynamics of microtubule modifications and how they relate to one another.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the paper’s main finding show about microtubule modifications?",{"text":117,"@type":113},"It shows that different microtubule modifications do not occur independently; their formation is interconnected and dependent on each other.",{"name":119,"@type":110,"acceptedAnswer":120},"What advice does Marinus Thein give to early-career researchers?",{"text":121,"@type":113},"Scientific progress often happens in incremental steps, and even small advances can meaningfully contribute to understanding the world.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},409127,1792241017,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":14,"category_name":15,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","© 2025 . Published by The Company of Biologists | Biology Open (2025) 14, bio062378 . doi:10 . 1242/bio.062378  \nFIRST PERSON  \nFirst person – Marinus Thein  \n\n| First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping researchers promote themselves alongside their papers. Marinus Thein is first author on ‘Effects of microtubule (de)tyrosination on the morphology and motility of Trypanosoma brucei and cross-talk with polyglutamylation’, published in BiO. Marinus is a PhD student in the lab of Professor Dr Klaus Ersfeld at University of Bayreuth, Bayreuth, Germany, investigating how the highly stable microtubule cytoskeleton of the parasite Trypanosoma brucei is regulated and how it achieves is structural integrity. |\n| --- |\n| Describe your scientific journey and your current research focus\u003Cbr>I have always been very interested in the natural sciences, especially biology and chemistry at school. So, I decided to combine them both and study biochemistry for my Bachelor’sand Master’s degrees. I joined the lab of Klaus Ersfeld for my Master’s and stayed for my PhD. Here, we are interested in the dynamics ofthe microtubules forming the cytoskeleton of the parasite Trypanosoma brucei.\u003Cbr>Who or what inspired you to become a scientist?\u003Cbr>I don’t think there is one singular person who inspired me. It is more science and life itself. I am always fascinated by how everything functions at molecular level, and investigating even the smallest parts of a whole complex mechanism/ organism can be so fascinating and eye-opening.\u003Cbr>How would you explain the main finding of your paper? Microtubules are essential cellular structures, and their malformation is often correlated with neurological diseases. This work further explores our understanding of how different sets of modifications on the essential microtubule proteins correlate with and regulate each other.\u003Cbr>What are the potential implications of this finding for your field of research?\u003Cbr>This work demonstrates that the various microtubule modifications do not occur in isolation, but, rather, they are interconnected and their formation is dependent on each other.\u003Cbr>Which part of this research project was the most rewarding? Probably noticing this cross-talk between the tubulin modifications directly in the cells. Before that, this interconnection was only hinted at or analysed in in vitro data.\u003Cbr>What do you enjoy most about being an early-career researcher?\u003Cbr>I really enjoy the fact that, in the early stages of your career, you can really pursue your scientific curiosity. |\n\nMarinus Thein’s contact details: Molecular Parasitology, Department of Biology, University of Bayreuth, Universittsstraße 30, 95447 Bayreuth, Germany. [E-mail: marinus.thein@uni-bayreuth.de](E-mail: marinus.thein@uni-bayreuth.de)  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0](https://creativecommons.org/licenses/by/4.0)), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.  \nMarinus Thein  \nWhat piece of advice would you give to the next generation of researchers?  \nScientific progress is often made in incremental steps. Not everything can be groundbreaking and novel; even the little advances can contribute meaningfully to the field and help us to better understand our world.  \nTransmission electron microscopy image of a cross-section of a trypanosome.  \nBiology Open  \nFIRST PERSON Biology Open (2025) 14, bio062378 . doi:10 . 1242/bio.062378  \nWhat’s next for you?  \nCurrently, my main focus is to start my internship abroad and, once I am back, to finish my PhD. After that, we will see what awaits me.  \nReference  \nThein, M., Wunderlich, H., Brehm, L., Wagner, S., Weiss, M. and Ersfeld, K.(2025) . Effects of microtubule (de)tyrosination on the morphology and motility","cbCaihriENUNyBvd","https://ap.wps.com/l/cbCaihriENUNyBvd","pdf",488844,"English","# Describe your scientific journey and your current research focus\n# Who or what inspired you to become a scientist?\n# How would you explain the main finding of your paper?\n# What are the potential implications of this finding for your field of research?\n# Which part of this research project was the most rewarding?\n# What do you enjoy most about being an early-career researcher?\n# What piece of advice would you give to the next generation of researchers?\n# What’s next for you?","[{\"question\":\"What is Marinus Thein researching in his current work?\",\"answer\":\"He studies how the highly stable microtubule cytoskeleton of Trypanosoma brucei is regulated, focusing on the dynamics of microtubule modifications and how they relate to one another.\"},{\"question\":\"What does the paper’s main finding show about microtubule modifications?\",\"answer\":\"It shows that different microtubule modifications do not occur independently; their formation is interconnected and dependent on each other.\"},{\"question\":\"What advice does Marinus Thein give to early-career researchers?\",\"answer\":\"Scientific progress often happens in incremental steps, and even small advances can meaningfully contribute to understanding the world.\"}]","First Person - Marinus Thein | PDF",1790581428]