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Forty-eight suspicious lymph nodes were assessed by FNAC with follow-up biopsy, and performance metrics were compared with histopathology.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/fine-needle-aspiration-cytology-of-lymph-nodes-in-metastatic-cancer-and-lymphoma-our-single-institut/331976/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/fine-needle-aspiration-cytology-of-lymph-nodes-in-metastatic-cancer-and-lymphoma-our-single-institut/331976.png","ImageObject",300,407,{"name":42,"@type":43},"Olivia Brown","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the purpose of using FNAC in enlarged lymph nodes?","Question",{"text":63,"@type":64},"The study investigates FNAC as a diagnostic approach to clarify the cause of suspicious lymphadenopathy, particularly for metastatic cancer and lymphoma.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were FNAC samples collected and processed in the study?",{"text":68,"@type":64},"A total of 48 suspicious lymph nodes were sampled for FNAC using 20–22 G needles with at least two passes, followed by slide preparation and staining, with residual material used for cytoblock.",{"name":70,"@type":61,"acceptedAnswer":71},"What diagnostic performance did FNAC show compared with histopathology?",{"text":72,"@type":64},"For epithelial metastatic cancer, cytology showed sensitivity, specificity, PPV, and NPV values reported in the study, and overall diagnostic accuracy was calculated; 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Accepted: Feb 27, 2024  \n© 2024 Sanela Vesnic, Anes Joguncic, Vesna Sarajlic, Mirsad Doric  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)  \n[by-nc/4.0/](by-nc/4.0/)) [which permits unrestricted non-commercial use](which permits unrestricted non-commercial use), [distribution](distribution), [and reproduction in any medium](and reproduction in any medium), [provided the original work is properly cited](provided the original work is properly cited).  \nORIGINAL PAPER Mater Sociomed. 2024; 36(1): 18-22  \nFine Needle Aspiration Cytology of Lymph Nodes in Metastatic Cancer and Lymphoma: Our Single-  \n1Department of Radiology, Clinical Center of University of Sarajevo, Sarajevo, Bosnia and Herzegovina  \n2Department of Epidemiology, Public Health Institute of Canton Sarajevo, Sarajevo, Bosnia and Herzegovina  \n3Department of Pathology, Faculty of Medicine University of Sarajevo, Sarajevo, Bosnia and Herzegovina  \nCorresponding author:  \nAnes Jogunncic, MD, Department of Epidemiology, Public Health Institute of Canton Sarajevo, Sarajevo, Bosnia and Herzegovina. Phone:  \n+387 61 364 035.  \nE-mail: anesj0710@ [gmail.com](gmail.com) or anes. [joguncic@zzjzks.ba](joguncic@zzjzks.ba). ORCID ID: [http//www](http//www). [orcid.org/0000-0000-](orcid.org/0000-0000-)[ ](orcid.org/0000-0000-)0000-0000.  \ninstitution Experience  \nSanela Vesnic1, Anes Joguncic2, Vesna Sarajlic1, Mirsad Doric3  \nABSTRACT  \nBackground: Lymphadenopathy is a common finding in clinical practice. The cause of enlarged nodes on clinical examination alone is challenging and there may be multiple reasons for this enlargement. It may become enlarged due to stimulation by infectious agents or the involvement of metastasis or malignant diseases, such as lymphoma. Objective: The aim of the study was to investigate the diagnostic role of fine needle aspiration cytology of lymph nodes in metastatic cancer and lymphoma. Methods: A total of 48 FNAC lymph nodes suspicious for malignancy were sampled with follow-up biopsy in Clinical Center of University of Sarajevo from 2017 to 2023. Lymph nodes were aspirated using 20-22 G needle with minimally 2 passes, spread on slides, air-dried, stained with May-Grünwald-Giemsa or Papanikolaou and residual material sent for cytoblock. Results: Out of 48 cytological samples, 30 (62.5%) revealed metastatic epithelial cells and 12 (25%) lymphoproliferative neoplasm. Three samples were suspected for malignancies, one sample was unrepresentative, one inconclusive and one falsely negative. Histopathological confirmation had 35 patients, while others were confirmed based on clinical presentation and radiological techniques. Compared to histopathological diagnosis, cytology had a sensitivity of 89.47%, specificity of 93.33%, positive predictive value (PPV) 95.04% and negative predictive values (NPV) 86. 13% for epithelial metastatic cancer. The overall diagnostic test accuracy was 91.06% . For lymphoproliferative neoplasms cytology in comparison to histopathology had sensitivity 85.71%, specificity 91.18%, PPV 76.4%  \nand NPV 95.04% . The overall diagnostic test accuracy was 89.81% . In both ways cytology is showing significant possibility to be used as a primary tool in detecting cancers. Conclusion: FNAC is a fast, reliable, and efficient method for diagnosing malignant lymphadenopathy. The cytological diagnosis can sometimes be accepted as the definitive diagnosis without further correlation with histopathology, especially in advanced malignancies and known primary malignancies.  \nKeywords: FNAC, malignant lymphadenopathy, sensitivity, specificity.  \n1. BACKGROUND  \nFine needle aspiration cytology (FNAC) stands as a widely utilized initial diagnostic and management tool for patients presenting with lymphadenopathy, owing to its esteemed advantage","cbCaikEP9fEkjJBM","https://ap.wps.com/l/cbCaikEP9fEkjJBM","pdf",209755,"English","# Abstract\n# Background\n## Study objective\n## Methods and sampling","[{\"question\":\"What is the purpose of using FNAC in enlarged lymph nodes?\",\"answer\":\"The study investigates FNAC as a diagnostic approach to clarify the cause of suspicious lymphadenopathy, particularly for metastatic cancer and lymphoma.\"},{\"question\":\"How were FNAC samples collected and processed in the study?\",\"answer\":\"A total of 48 suspicious lymph nodes were sampled for FNAC using 20–22 G needles with at least two passes, followed by slide preparation and staining, with residual material used for cytoblock.\"},{\"question\":\"What diagnostic performance did FNAC show compared with histopathology?\",\"answer\":\"For epithelial metastatic cancer, cytology showed sensitivity, specificity, PPV, and NPV values reported in the study, and overall diagnostic accuracy was calculated; similar comparative metrics were provided for lymphoproliferative neoplasms.\"}]","Fine Needle Aspiration Cytology of Lymph Nodes in Metastatic Cancer and Lymphoma - Our Single-institut | PDF",1789996104,13]