[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328026-105":59,"doc-detail-328026-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","field-cancerization-in-dermatology-review-article","Field cancerization in dermatology - Review Article","","Field cancerization in dermatology explains how long-term exposure to aggressive factors—especially sunlight and radiation therapy—can create diffuse areas of altered skin. The review describes the concept introduced in 1953, emphasizing atypical cells and the evolution from sun-damaged tissue to actinic keratoses and epithelial malignancies. It outlines associated risk factors such as chronic childhood sun exposure, fair skin, older age, immunosuppression, and prior squamous cell carcinoma. Clinical and histopathological manifestations guide careful surveillance and combined treatment planning.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/field-cancerization-in-dermatology-review-article/328026/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/field-cancerization-in-dermatology-review-article/328026.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is field cancerization in dermatology?","Question",{"text":112,"@type":113},"Field cancerization refers to sun-damaged or clinically normal skin areas that show underlying pathological changes, often associated with actinic keratoses and malignant epithelial tumors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors increase the risk of developing field cancerization?",{"text":117,"@type":113},"Chronic sun exposure is the main factor, especially early-life exposure, with higher risk in fair-skinned people, older patients, immunosuppressed individuals, and those with a history of squamous cell carcinoma.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is actinic keratosis important in this context?",{"text":121,"@type":113},"Actinic keratosis is highlighted as the key lesion on examination because it can act as a precursor to squamous cell carcinoma and may display atypia during progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328026,1790097597,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","REVIEW ARTICLE  \n[https://doi.org/10.1590/1806-9282.2024S113](https://doi.org/10.1590/1806-9282.2024S113)  \nField cancerization in dermatology  \nRenata Ferreira Magalhães1 , Thais Helena Buffo2 , Heitor deSá Gonçalves3 , Carlos Baptista Barcaui4 , Aparecida Machado de Moraes1*   \nBrazilian Society of Dermatology (SBD)  \nINTRODUCTION  \nThe concept of the cancerization field was described in 1953 when a group of pathologists, studying malignant neoplasms of the mouth, detected atypical cells far from the main malignant lesion. It could be assumed that there was a carcinogenic stimulus, with modifications already existing in the nucleus of the cells, in apparently normal skin.  \nThis change became evident where areas intensely exposed to the sun showed a frequent and progressive appearance of malignant and pre-malignant lesions1,2 .  \nThe definition of a field cancerization (CC) in dermatology is not yet fully established and is based on the visible identification of signs of sun damage associated with the finding of actinic keratoses and malignant epithelial tumors3.  \nThe field cancerization by photo exposure is the most studied in dermatology.  \nThe observation of this occurrence made it important to plan and approach patients with this alteration, as there was the potential for the condition to progress.  \nOn the skin, in areas exposed to an aggressive factor such as sun exposure or radiation therapy, xerosis, atrophy, scaling, actinic melanosis, leukoderma, actinic keratosis, and tumors such as epidermoid carcinoma1,4,5 .  \nIn medical practice, highlighting this risk area is important for treatment, periodic and ongoing follow-up, and attention to the eventual appearance of more serious injuries.  \nThere is still disagreement in the literature as to the exact field of cancerization, but some findings are considered highlights, such as actinic keratosis1,4 (Figure 1) .  \nASSOCIATED FACTORS  \nSeveral factors may be associated with the development of afield cancerization, the most notable being chronic sun exposure. Sun exposure from childhood is considered and, even if the patient does not give correct information about the intensity and time of exposure, indirect data such as sports practices, free leisure activities, and rural work should be considered (Figure 2) .  \nThere is a greater risk in fair-skinned individuals, older patients, and immunosuppressed patients such as transplant patients.  \nA history of a lesion treated with a diagnosis of squamous cell carcinoma puts the region at greater risk of developing others4,5 .  \nFigure 1. Multiple actinic keratoses on the face and squamous cell carcinoma on the neck.  \n1 Universidade Estadual de Campinas, Clinical Hospital, Division of Dermatology – São Paulo (SP), Brazil.  \n2Universidade Estadual de Campinas, Clinical Hospital, Department of Dermatology Surgery and Skin Cancer, Division of Dermatology–São Paulo (SP), Brazil.  \n3Center for Health Dermatology Dona Libânia – Fortaleza (CE), Brazil.  \n4 Universidade Federal do Rio de Janeiro – Rio de Janeiro (RJ), Brazil.  \n*Corresponding author: [amacmoras@gmail.com](amacmoras@gmail.com)  \nConflicts of interest: the authors declare there is no conflicts of interest. Funding: none.  \nReceived on October 19, 2023. Accepted on October 20, 2023.  \n1  \nRev Assoc Med Bras. 2024;70(Suppl 1):e2024S113  \nCLINICAL MANIFESTATIONS  \nThe lesion that stands out on examination is actinic keratosis. It can be a precursor to squamous cell carcinoma or show histopathological atypia in the process of developing into carcinoma.  \nActinic keratosis can be single or multiple, as papular lesions with hyperkeratosis and erythema.  \nThey may be painful, have a burning sensation, or feel like a “thorn in the skin.” They may be more palpable than visible, giving a feeling of local roughness.  \nHyperkeratosis, which can be pronounced, suggests the shape of a cutaneous horn.  \nThere are agglomerated, confluent actinic keratoses, forming extensive hyperkerato","cbCaivMzeSJtkEUI","https://ap.wps.com/l/cbCaivMzeSJtkEUI","pdf",3975922,"English","# Introduction\n# Associated Factors\n# Clinical Manifestations\n# Histopathological Aspects\n# Treatments","[{\"question\":\"What is field cancerization in dermatology?\",\"answer\":\"Field cancerization refers to sun-damaged or clinically normal skin areas that show underlying pathological changes, often associated with actinic keratoses and malignant epithelial tumors.\"},{\"question\":\"Which factors increase the risk of developing field cancerization?\",\"answer\":\"Chronic sun exposure is the main factor, especially early-life exposure, with higher risk in fair-skinned people, older patients, immunosuppressed individuals, and those with a history of squamous cell carcinoma.\"},{\"question\":\"Why is actinic keratosis important in this context?\",\"answer\":\"Actinic keratosis is highlighted as the key lesion on examination because it can act as a precursor to squamous cell carcinoma and may display atypia during progression.\"}]","Field cancerization in dermatology - Review Article | PDF",1789978544,15]