[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-410136-105":59,"doc-detail-410136-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","fibrinogen-supplementation-enhances-antivenom-efficacy-in-treating-coagulopathy-due-to-hemotoxic-snakebite-envenoming","Fibrinogen supplementation enhances antivenom efficacy in treating coagulopathy due to hemotoxic snakebite envenoming","","Adjunctive fibrinogen supplementation was evaluated as a supportive strategy for hemotoxic snakebite envenoming, where timely antivenom administration remains central but may be delayed and complicated by venom variability and patient differences. A retrospective multicenter study analyzed 116 cases caused by Trimeresurus and Agkistrodon species in Yunnan, China, comparing antivenom alone versus antivenom plus fibrinogen. Combined therapy showed improved coagulation indices, higher fibrinogen levels at discharge, and a shorter hospital stay, supporting potential clinical utility pending further evaluation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fibrinogen-supplementation-enhances-antivenom-efficacy-in-treating-coagulopathy-due-to-hemotoxic-snakebite-envenoming/410136/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fibrinogen-supplementation-enhances-antivenom-efficacy-in-treating-coagulopathy-due-to-hemotoxic-snakebite-envenoming/410136.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What treatment strategy was assessed for hemotoxic snakebite envenoming?","Question",{"text":112,"@type":113},"The study assessed adjunctive fibrinogen (Fg) supplementation given alongside standard antivenom therapy, compared with antivenom alone.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which types of snakebite envenoming cases were included?",{"text":117,"@type":113},"Cases were caused by hemotoxic snakebite envenoming from Trimeresurus stejnegeri, Trimeresurus mucrosquamatus, and Agkistrodon halys species in Yunnan, China.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main outcome findings of the fibrinogen plus antivenom regimen?",{"text":121,"@type":113},"Compared with antivenom-only treatment, the combined regimen improved coagulation laboratory parameters, increased fibrinogen levels by discharge, and shortened hospital stay.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},410136,1791311679,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","TYPE Original Research PUBLISHED 18 December 2025 DOI 10. 3389/fmed.2025.1667800  \nOPEN ACCESS  \nEDITED BY  \nNaoual Oukkache,  \nInstitut Pasteur du Maroc, Morocco  \nREVIEWED BY  \nMuhamad Rusdi Ahmad Rusmili, International Islamic University Malaysia, Malaysia  \nMitchel Okumu,  \nUniversity of the Free State, South Africa Jacob Galan,  \nThe University of Texas Rio Grande Valley, United States  \n*CORRESPONDENCE  \nZengzheng Li  \n [lizengzheng@126.com](lizengzheng@126.com)[ ](lizengzheng@126.com)Bin Han  \n [handuancongcong@163.com](handuancongcong@163.com)  \n†These authors have contributed equally to this work  \nRECEIVED 17 July 2025  \nACCEPTED 02 December 2025  \nPUBLISHED 18 December 2025  \nCITATION  \nGao Q, Wang Y, Teng Y, Huang Q, Wang Y, Feng S, Han B and Li Z (2025) Fibrinogen supplementation enhances antivenom efficacy in treating coagulopathy due tohemotoxic snakebite envenoming by Trimeresurus and Agkistrodon species in Yunnan, China. Front. Med. 12:1667800 .  \ndoi: 10.3389/fmed.2025.1667800  \nCOPYRIGHT  \n© 2025 Gao, Wang, Teng, Huang, Wang, Feng, Han and Li. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nFibrinogen supplementation enhances antivenom efficacy in treating coagulopathy due tohemotoxic snakebite envenoming by Trimeresurus and Agkistrodon species in Yunnan, China  \nQinfen Gao1†, Yi Wang1†, Yajun Teng1†, Qunyan Huang2 , Ya Wang3 , Shuai Feng4,5,6 , Bin Han1* and Zengzheng Li4,5,6*  \n1 Department of Emergency, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China, 2 Department of Emergency, The First People’s Hospital of Xuanwei City, Xuanwei, China, 3 Department of Emergency, The People’s Hospital of Linxiang District, Lincang, China, 4 Department of Hematology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China,  \n5Yunnan Province Clinical Research Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China, 6Yunnan Province Clinical Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China  \nBackground: Timely administration of antivenom remains the cornerstone of treatment for hemotoxic snakebite envenoming, primarily aimed at neutralizing circulating toxins and halting the progression of venom-induced consumption coagulopathy (VICC), thus facilitating gradual recovery of the hemostatic system. However, immediate access to antivenom is not always possible, and variations in venom composition among snake species, along with individual patient differences, can result in significant morbidity (including persistent complications of coagulopathy) and mortality.  \nMethods: This retrospective study evaluated 116 cases of hemotoxic snakebite envenoming caused by Trimeresurus stejnegeri, T. mucrosquamatus, and Agkistrodon halys at three hospitals in Yunnan Province, China (The First People’s Hospital of Yunnan Province 63 cases, The People’s Hospital of Linxiang District 28 cases, and The First People’s Hospital of Xuanwei City 25 cases). Among these, thirty-three patients consented to receive adjunctive therapy with fibrinogen (Fg) in addition to standard antivenom treatment (Agkistrodon acutus antivenom or Agkistrodon halys antivenom), while the remaining 83 received antivenom alone. Coagulation parameters were measured at admission and discharge. Statistical analyses were performed using IBM SPSS Statistics and GraphPad Prism, employing the Mann-Whitney U test for non-normally distributed da","cbCailvfUt0anZXW","https://ap.wps.com/l/cbCailvfUt0anZXW","pdf",1123665,"English","# Introduction\n## Methods\n## Results\n## Conclusions\n# Keywords","[{\"question\":\"What treatment strategy was assessed for hemotoxic snakebite envenoming?\",\"answer\":\"The study assessed adjunctive fibrinogen (Fg) supplementation given alongside standard antivenom therapy, compared with antivenom alone.\"},{\"question\":\"Which types of snakebite envenoming cases were included?\",\"answer\":\"Cases were caused by hemotoxic snakebite envenoming from Trimeresurus stejnegeri, Trimeresurus mucrosquamatus, and Agkistrodon halys species in Yunnan, China.\"},{\"question\":\"What were the main outcome findings of the fibrinogen plus antivenom regimen?\",\"answer\":\"Compared with antivenom-only treatment, the combined regimen improved coagulation laboratory parameters, increased fibrinogen levels by discharge, and shortened hospital stay.\"}]","Fibrinogen supplementation enhances antivenom efficacy in treating coagulopathy due to hemotoxic snakebite envenoming | PDF",1790584398,25]