[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-385097-105":59,"doc-detail-385097-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","fibres-and-colorectal-cancer-clinical-and-molecular-evidence","Fibres and Colorectal Cancer: Clinical and Molecular Evidence","","Colorectal cancer (CRC) is a leading cause of cancer mortality, with diet playing a central role. Insufficient dietary fiber intake is common in industrialized Western settings and is linked to higher CRC risk in epidemiologic studies, while dietary fibers also influence long-term outcomes in CRC survivors. Potential mechanisms include effects on bile acid metabolism and colon carcinogenesis, antioxidant compounds in fiber-rich vegetables, microbial digestion producing butyrate with antiproliferative activity, and modulation of gut microbiota associated with CRC onset.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fibres-and-colorectal-cancer-clinical-and-molecular-evidence/385097/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fibres-and-colorectal-cancer-clinical-and-molecular-evidence/385097.png","ImageObject",300,407,{"name":92,"@type":93},"Đào","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How is dietary fiber linked to colorectal cancer risk?","Question",{"text":113,"@type":114},"Epidemiologic studies show an inverse relationship between daily fiber intake and CRC risk. The document also notes diet-related influences on long-term prognosis in CRC survivors.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What molecular mechanisms could explain fiber’s role in CRC?",{"text":118,"@type":114},"Possible mechanisms include interference with bile acid metabolism, production of antiproliferative compounds such as butyrate from fiber digestion by commensal flora, and modulation of gut microbiota composition associated with CRC onset.",{"name":120,"@type":111,"acceptedAnswer":121},"Which genetic pathways and instability types are discussed for colorectal cancer?",{"text":122,"@type":114},"CRC is classified into sporadic, inherited, and familial forms, with three main genetic pathways: chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP).","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},385097,1790320579,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Review  \nFibres and Colorectal Cancer: Clinical and Molecular Evidence  \nFrancesca Celiberto 1,2, Adriana Aloisio 1, Bruna Girardi 3, Maria Pricci 3, Andrea Iannone 1, Francesco Russo 4, Giuseppe Riezzo 4, Benedetta D'Attoma 4, Enzo Ierardi 1, Giuseppe Losurdo 1 and Alfredo Di Leo 1, *  \nCitation: Celiberto, F.; Aloisio, A.; Girardi, B.; Pricci, M.; Iannone, A.; Russo, F.; Riezzo, G.; D'Attoma, B.; Ierardi, E.; Losurdo, G.; et al. Fibres and Colorectal Cancer: Clinical and Molecular Evidence. Int. J. Mol. Sci. 2023, 24, 13501. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms241713501](10.3390/ijms241713501)  \nAcademic Editors: Lorenza Trabalzini and Federica Finetti  \nReceived: 29 July 2023  \nRevised: 30 August 2023  \nAccepted: 30 August 2023  \nPublished: 31 August 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy  \n2 Ph.D. Course in Organs and Tissues Transplantation and Cellular Therapies, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy  \n3 THD s.p.a., 42015 Correggio, Italy  \n4 Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS“Saverio de Bellis”, 70013 Castellana Grotte, Italy; [francesco.russo@irccsdebellis.it](francesco.russo@irccsdebellis.it) (F.R.); [giuseppe.riezzo@irccsdebellis.it](giuseppe.riezzo@irccsdebellis.it) (G.R.); [benedetta.dattoma@irccsdebellis.it](benedetta.dattoma@irccsdebellis.it) (B.D.)  \n* Correspondence: [alfredo.dileo@uniba.it](alfredo.dileo@uniba.it); Tel.: +39-080-5592925  \nAbstract: Colorectal cancer (CRC) is one of the leading causes of mortality for cancer in industrialized countries. The link between diet and CRC is well-known, and presumably CRC is the type of cancer which is most influenced by dietary habits. In Western countries, an inadequate dietary intake of fibers is endemic, and this could be a driving factor in the increase of CRC incidence. Indeed, several epidemiologic studies have elucidated an inverse relationship between daily fiber intake and risk of CRC. Long-term prognosis in CRC survivors is also dependent on dietary fibers. Several pathogenetic mechanisms may be hypothesized. Fibers may interfere with the metabolism of bile acids, which may promote colon carcinogenesis. Further, fibers are often contained in vegetables which, in turn, contain large amounts of antioxidant agents like resveratrol, polyphenols, or phytoestrogens. Moreover, fiberscan be digested by commensal flora, thus producing compounds such as butyrate, which exerts an antiproliferative effect. Finally, fibers may modulate gut microbiota, whose composition has shown to be associated with CRC onset. In this regard, dietary interventions based on high-fiber-containing diets are ongoing to prevent CRC development, especially in patients with high potential for this typeof tumor. Despite the fact that outcomes are preliminary, encouraging results have been observed.  \nKeywords: colorectal cancer; fibers; diet; chemoprevention  \n1. Introduction: Epidemiology and Molecular Basis of Colorectal Cancer  \nColorectal cancer (CRC) is one of the most common malignancies, being the third leading cause of cancer death worldwide, mostly in Europe and the United States, although there has been a rise in its incidence in Asia over recent decades. In 2018, the incidence of new cases was approximately 2 million, while it caused 1 million deaths worldwide [1] .  \nColorectal carcinoma is classified into sporadic (70%), inherited (5%), and familial (25%) . There are three ","cbCaipPK55gofpJ9","https://ap.wps.com/l/cbCaipPK55gofpJ9","pdf",1186491,"English","# Abstract\n# Keywords\n# Introduction: Epidemiology and Molecular Basis of Colorectal Cancer\n## Epidemiology of colorectal cancer\n## Genetic pathways: CIN, MSI, and CIMP\n## Signaling pathways and APC/Wnt-β-catenin mechanism","[{\"question\":\"How is dietary fiber linked to colorectal cancer risk?\",\"answer\":\"Epidemiologic studies show an inverse relationship between daily fiber intake and CRC risk. The document also notes diet-related influences on long-term prognosis in CRC survivors.\"},{\"question\":\"What molecular mechanisms could explain fiber’s role in CRC?\",\"answer\":\"Possible mechanisms include interference with bile acid metabolism, production of antiproliferative compounds such as butyrate from fiber digestion by commensal flora, and modulation of gut microbiota composition associated with CRC onset.\"},{\"question\":\"Which genetic pathways and instability types are discussed for colorectal cancer?\",\"answer\":\"CRC is classified into sporadic, inherited, and familial forms, with three main genetic pathways: chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP).\"}]","Fibres and Colorectal Cancer: Clinical and Molecular Evidence | PDF",1790266724,28]