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Most interventions emphasize lifestyle changes, yet evidence remains uncertain regarding whether pharmacologic options can prevent or reduce frailty. This systematic review evaluates the efficacy of existing drug-based interventions using PRISMA-guided searches of PubMed, CINAHL, and ClinicalTrials.gov through 10 June 2025. Ten randomized controlled trials were included; results show variable efficacy, with several interventions demonstrating promise and others showing no reduction in overall or incident frailty.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/few-pharmacologic-interventions-prevent-or-mitigate-frailty-a-systematic-review/426468/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/few-pharmacologic-interventions-prevent-or-mitigate-frailty-a-systematic-review/426468.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of this systematic review?","Question",{"text":112,"@type":113},"To explore the efficacy of existing pharmacologic options for preventing or mitigating frailty in older adults.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were studies selected for inclusion?",{"text":117,"@type":113},"Following PRISMA guidelines, the review searched PubMed, CINAHL, and ClinicalTrials.gov through 10 June 2025, and included only randomized controlled trials using validated frailty measures.",{"name":119,"@type":110,"acceptedAnswer":120},"Which pharmacologic interventions showed promise and which did not?",{"text":121,"@type":113},"L-carnitine, higher-dose protein supplementation, testosterone therapy, and intravenous allogenic mesenchymal stem cells showed promise, while prebiotics, aspirin, vitamin D3 with omega-3s, canakinumab, and metformin showed no reduction in overall or incident frailty.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426468,1791041105,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","1068 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.3592  \nFEW PHARMACOLOGIC INTERVENTIONS PREVENT  \nOR MITIGATE FRAILTY: A SYSTEMATIC REVIEW  \nLeah Bolles1, Michael DeGloria1, Hailey Cray1, Rebekah Harris1, Saadia Qazi1, and Ariela Orkaby2, 1. VA Boston Healthcare System, Boston, Massachusetts, United States, 2. Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States  \nFrailty is a multidimensional clinical syndrome which limits the ability of older adults to cope with both everyday and acute stressors. To date, most interventions for frailty target lifestyle improvements, however, uncertainty remains as to whether pharmacologic interventions may prevent or mitigate this syndrome.  \nTherefore, this systematic review aims to explore the efficacy of existing pharmacologic options for the treatment of frailty.  \nFollowing PRISMA guidelines, we conducted our search using PubMed, CINAHL, and ClinicalTrials.gov from article inception to 10 June 2025. Only randomized controlled trials evaluating the effect of pharmacologic interventions on validated frailty measures were included. Two authors independently screened articles and extracted data, and disagreements were resolved through a third author. After screening 747 titles and abstracts, 33 full text manuscripts were extracted, and 10 trials were included. Results indicated varying efficacy across unique pharmacologic interventions. L-carnitine, protein supplementation at higher doses, testosterone therapy, and intravenous allogenic mesenchymal stem cells show promise in preventing and/or reducing frailty. Prebiotic administration, aspirin, vitamin D3 with omega-3 fatty acids, canakinumab, and metformin showed no reduction in overall or incident frailty. Notably, the combined supplementation of vitamin D3, omega-3s, and a structured exercise program reduced the risk of becoming pre-frail. Data were insufficient to conduct a meta-analysis. Although some pharmacologic interventions exhibit potential benefits, data remains limited in guiding therapeutic approaches to prevent or mitigate frailty in older adults.","cbCaiqhTXNOIhbui","https://ap.wps.com/l/cbCaiqhTXNOIhbui","pdf",943546,"English","# Abstract\n## Review scope and rationale\n## Methods and study selection\n## Results and key findings","[{\"question\":\"What was the purpose of this systematic review?\",\"answer\":\"To explore the efficacy of existing pharmacologic options for preventing or mitigating frailty in older adults.\"},{\"question\":\"How were studies selected for inclusion?\",\"answer\":\"Following PRISMA guidelines, the review searched PubMed, CINAHL, and ClinicalTrials.gov through 10 June 2025, and included only randomized controlled trials using validated frailty measures.\"},{\"question\":\"Which pharmacologic interventions showed promise and which did not?\",\"answer\":\"L-carnitine, higher-dose protein supplementation, testosterone therapy, and intravenous allogenic mesenchymal stem cells showed promise, while prebiotics, aspirin, vitamin D3 with omega-3s, canakinumab, and metformin showed no reduction in overall or incident frailty.\"}]","FEW PHARMACOLOGIC INTERVENTIONS PREVENT OR MITIGATE FRAILTY - A SYSTEMATIC REVIEW | PDF",1790640671]