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Within 48 hours of stopping ulinastatin, fever subsided and the patient stabilized, highlighting drug-induced fever as an important adverse reaction.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/fever-in-a-patient-with-mild-acute-pancreatitis-caused-by-ulinastatin-injection-a-case-report/455082/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/fever-in-a-patient-with-mild-acute-pancreatitis-caused-by-ulinastatin-injection-a-case-report/455082.png","ImageObject",300,407,{"name":42,"@type":43},"Blitz","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"Why was ulinastatin-related drug fever suspected in this case?","Question",{"text":62,"@type":63},"Fever persisted despite antibiotics, while repeated tests showed normal procalcitonin and blood cultures had no bacterial or fungal growth. Imaging revealed pancreatitis findings without necrosis or infection, supporting a drug-induced cause.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What treatments were used before ulinastatin was stopped?",{"text":67,"@type":63},"The patient received conservative acute pancreatitis care (fasting, rehydration, inhibiting digestive fluid secretion, and acid suppression). Antibiotics were given for suspected infection, starting with ceftriaxone and later switching to imipenem.",{"name":69,"@type":60,"acceptedAnswer":70},"What was the clinical outcome after discontinuing ulinastatin?",{"text":71,"@type":63},"After stopping ulinastatin on March 21, the patient’s maximum temperature decreased by March 22 and returned to normal by March 23. Discharge occurred on March 28 without recurrence of fever.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},455082,1790742076,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":30,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":79,"read_time":110,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","®  \n Clinical Case Report   \nFever in a patient with mild acute pancreatitis caused by ulinastatin injection  \nA case report  \nTong Wu, MDa , Linzhen Li, MDa , Yan Zhang, PhDa ,*  \n\n| Abstract\u003Cbr>Rationale: The case describes a patient with mild acute pancreatitis (AP) who developed a persistent high fever during ulinastatin treatment. This highlights the possibility of drug-induced fever, which is a rare but important adverse reaction of ulinastatin and is often overlooked in clinical practice.\u003Cbr>Patient concerns: A 58-year-old male patient with mild AP had a persistent high fever during the treatment with ulinastatin, but there was no evidence of infection.\u003Cbr>Diagnoses: Mild AP, ulinastatin-related drug fever.\u003Cbr>Interventions: The initial conservative treatment for AP included fasting, rehydration and taking ulinastatin. Antibiotics (ceftriaxone, later changed to imipenem) were used for suspected infection. After excluding infection, ulinastatin was discontinued. Outcomes: Within 48 hours of stopping ulinastatin, the patient’s fever symptoms were relieved and his subsequent condition stabilized.\u003Cbr>Lessons: This case highlights the importance of considering drug-induced fever in clinical practice. Recognizing it promptly and discontinuing the drug can prevent unnecessary interventions and improve outcomes.\u003Cbr>Abbreviations: AP = acute pancreatitis, CT = computed tomography. |\n| --- |\n| Keywords: acute pancreatitis, fever, ulinastatin injection |\n\n1. Introduction  \nAcute pancreatitis (AP) is a prevalent acute abdominal disease with a complex pathogenesis in which the inflammatory response plays a key role. Ulinastatin, as a serine protease inhibitor, can alleviate inflammation and tissue damage, and reduce the mortality of patients. [1] However, ulinastatin may also cause some adverse reactions during clinical application. This article reports a case of fever during the treatment of mild AP with ulinastatin, aiming to improve clinicians’ understanding of the adverse reactions of the drug and provide a reference for the safe and rational use of the drug.  \n2. Case report  \nA 58-year-old male was admitted to the hospital on March 15, 2025 for left upper abdominal pain after drinking for 2 days. The patient was in good health normally, with no history of chronic diseases such as hypertension, diabetes, coronary heart disease. He had no history of drug allergies such as penicillins,  \nThe authors have no funding and conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.  \nWritten informed consent was obtained from the patient for publication of this case report and accompanying images.  \na Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China.  \n* Correspondence: Yan Zhang, Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical College, No. 2, Zheshan West Road, Jinghu District, Wuhu 241001, Anhui Province, China ([e-mail: yanyan0921@sina.com](e-mail: yanyan0921@sina.com)).  \ncephalosporins, sulfonamides, and no history of food allergies such as seafood, mango. There was no history of drug allergies or autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus in the family. The patient was accompanied by nausea, fatigue and anorexia. Vital signs were normal. On physical examination, he appeared sick, with moderate left epigastric tenderness. A full abdominal computed tomography (CT) scan and blood amylase examination in another hospital indicated AP. A diagnosis of AP was made, and the patient was treated conservatively, including fasting, rehydration, inhibit digestive fluid secretion, and acid suppression. Ulinastatin (100,000 IU/time, intravenous drip, 1 time/24 hours) was also used. On the day of admission, the patient had fever with a temperature of 38.4℃, therefore, ceftriaxone was given anti-inf","cbCaiemGotXccZCT","https://ap.wps.com/l/cbCaiemGotXccZCT","pdf",515071,"English","# Abstract\n## Rationale\n## Patient concerns\n## Diagnoses\n## Interventions\n## Outcomes\n## Lessons\n# 1. Introduction\n# 2. Case report\n# 3. Discussion","[{\"question\":\"Why was ulinastatin-related drug fever suspected in this case?\",\"answer\":\"Fever persisted despite antibiotics, while repeated tests showed normal procalcitonin and blood cultures had no bacterial or fungal growth. Imaging revealed pancreatitis findings without necrosis or infection, supporting a drug-induced cause.\"},{\"question\":\"What treatments were used before ulinastatin was stopped?\",\"answer\":\"The patient received conservative acute pancreatitis care (fasting, rehydration, inhibiting digestive fluid secretion, and acid suppression). Antibiotics were given for suspected infection, starting with ceftriaxone and later switching to imipenem.\"},{\"question\":\"What was the clinical outcome after discontinuing ulinastatin?\",\"answer\":\"After stopping ulinastatin on March 21, the patient’s maximum temperature decreased by March 22 and returned to normal by March 23. Discharge occurred on March 28 without recurrence of fever.\"}]","Fever in a patient with mild acute pancreatitis caused by ulinastatin injection - A case report | PDF"]