[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-434885-105":59,"doc-detail-434885-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ferumoxytol-enhanced-cardiovascular-magnetic-resonance-imaging-applications-and-technical-advances","Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances","","Magnetic resonance imaging with gadolinium chelates has reshaped cardiovascular diagnosis and therapy, spanning anatomy, function, tissue characterization, vascular imaging, and blood-flow quantification. Although gadolinium-based contrast agents have a strong safety record, concerns about gadolinium retention necessitate careful risk–benefit consideration in selected patients. Ferumoxytol has emerged as an off-label, versatile blood-pool contrast agent for cardiovascular magnetic resonance. With high r1 and r2 relaxivities, this intravenous iron supplement offers diagnostic and therapeutic relevance; this review summarizes its properties, highlights research directions, showcases expanding ferumoxytol-enhanced CMR applications, and addresses safety.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ferumoxytol-enhanced-cardiovascular-magnetic-resonance-imaging-applications-and-technical-advances/434885/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ferumoxytol-enhanced-cardiovascular-magnetic-resonance-imaging-applications-and-technical-advances/434885.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is ferumoxytol-enhanced cardiovascular magnetic resonance (CMR) used for?","Question",{"text":112,"@type":113},"It uses ferumoxytol as a versatile blood-pool contrast agent to support cardiovascular MRI applications, with the review summarizing multiple growing CMR use cases.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is ferumoxytol considered a relevant contrast agent for CMR?",{"text":117,"@type":113},"Ferumoxytol has high r1 and r2 relaxivities and is a clinically available intravenous iron supplement with roles spanning diagnostic and therapeutic dimensions.",{"name":119,"@type":110,"acceptedAnswer":120},"What safety issues does the review address?",{"text":121,"@type":113},"The review discusses safety in the context of contrast-enhanced CMR, including concerns related to gadolinium retention and a dedicated conclusion on ferumoxytol safety.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},434885,1790790762,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Journal of Cardiovascular Magnetic Resonance 27 (2025) 101980  \nContents lists available at ScienceDirect  \nJournal of Cardiovascular Magnetic Resonance  \njournal [homepage:](homepage: www.sciencedirect.com/journal/joc mr)[ www.sciencedirect.com/journal/joc mr](homepage: www.sciencedirect.com/journal/joc mr)  \nReview Article  \nFerumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances  \nKim-Lien Nguyena,b,c,d,⁎, Yue-Hin Lokee, Jennifer M. Lia, Arash Bedayatb, Hsin-Jung Yangf, Yibin Xief, Anthony G. Christodouloub,c,d, Debiao Lic,f, Xiaodong Zhongb,c,d, J. Paul Finnb,d,⁎⁎  \na Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA  \nb Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USAc Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA  \nd Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, California, USA e Division of Cardiology, Children’s National Hospital, Washington, DC, USA  \nf Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA  \n\n| A R T I C L E I N F O |  | A B S T R A C T |\n| --- | --- | --- |\n| Key Words: Ferumoxytol USPIOVenography\u003Cbr>Cardiovascular magnetic resonance Magnetic resonance angiography |  | Magnetic resonance imaging with gadolinium chelates has transformed the diagnostic practice of cardiovascular medicine. From anatomic and functional cardiac imaging to myocardial tissue composition, vascular imaging, and blood flow measurement, the clinical benefits of contrast-enhanced cardiovascular magnetic resonance (CMR) are well established. Since their introduction over 40 years ago, gadolinium chelates have had an excellent safety track record; however, concerns related to gadolinium retention have prompted in-depth consideration of potential risks and benefits in some patient groups. Recently, ferumoxytol has emerged as an offlabel, versatile blood-pool contrast agent for CMR. Endowed with high r1 and r2 relaxivities, ferumoxytol is a clinically available intravenous iron supplement that was initially designed as a diagnostic agent and in 2025, was approved by the U.S. Food and Drug Administration for brain imaging. Because iron is vital for many biological processes, ferumoxytol spans both diagnostic and therapeutic dimensions. In this review, we summarize the attributes of ferumoxytol, highlight promising research directions, and illustrate several growing ferumoxytol-enhanced CMR applications. We conclude with a discussion of safety. |\n\n1. Introduction  \nWidely recognized strengths of cardiovascular magnetic resonance (CMR) are its unrivaled soft tissue contrast and its inherent sensitivity to blood flow. Unlike other modalities that depend on one tissue property for image formation, CMR uses several contrast mechanisms, including intrinsic tissue properties to generate the information content encoded in the images. Since the first description of gadopentetate  \ndimeglumine (Magnevist) for human use in 1984 [1], contrast-enhanced MRI has become essential for disease diagnosis and treatment worldwide. To date, over half a billion doses of gadolinium-based contrast agents (GBCAs) have been administered and 30% of all magnetic resonance exams involve the use of exogenous contrast agents [2]. Gadolinium agents boast an enviable safety record, with the reported rate of acute adverse events for newer agents less than 0.36%[3]. Whereas their association with nephrogenic systemic fibrosis in stage  \nAbbreviations: CMR, Cardiovascular magnetic resonance; GBCA, Gadolinium-based contrast agent; MRI, Magnetic resonance imaging; MRA, Magnetic resonance angiography; USPIO, Ultrasmall superparamagnetic iron oxide; 2D, two-dimensional; 3D, three-dimensional; 5D, five-dimensional; FDA, United States Food","cbCaitZm8uu9GUo3","https://ap.wps.com/l/cbCaitZm8uu9GUo3","pdf",15077502,16,"English","# Introduction\n## Contrast-enhanced cardiovascular magnetic resonance and safety context\n# Ferumoxytol as an alternative blood-pool contrast agent\n## Properties and relaxivity rationale\n# Applications of ferumoxytol-enhanced CMR\n## Expanding diagnostic use cases\n# Research directions and technical advances\n## Emerging methods and approaches\n# Safety considerations","[{\"question\":\"What is ferumoxytol-enhanced cardiovascular magnetic resonance (CMR) used for?\",\"answer\":\"It uses ferumoxytol as a versatile blood-pool contrast agent to support cardiovascular MRI applications, with the review summarizing multiple growing CMR use cases.\"},{\"question\":\"Why is ferumoxytol considered a relevant contrast agent for CMR?\",\"answer\":\"Ferumoxytol has high r1 and r2 relaxivities and is a clinically available intravenous iron supplement with roles spanning diagnostic and therapeutic dimensions.\"},{\"question\":\"What safety issues does the review address?\",\"answer\":\"The review discusses safety in the context of contrast-enhanced CMR, including concerns related to gadolinium retention and a dedicated conclusion on ferumoxytol safety.\"}]","Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances | PDF",1790670977]