[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-372483-105":59,"doc-detail-372483-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ferulic-acid-as-a-promising-candidate-for-developing-selective-and-effective-anti-cancer-therapies","Ferulic acid as a promising candidate for developing selective and effective anti-cancer therapies","","Cancer remains a major global cause of death, with rising incidence for breast, colon, lung, and prostate cancers partly driven by limited effectiveness of current drugs. This review synthesizes the latest literature on ferulic acid (FA) and its anti-cancer potential from natural sources. It analyzes FA’s effects across cancer cell lines and describes underlying mechanisms, emphasizing antioxidant and anti-inflammatory actions that support therapeutic applicability.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ferulic-acid-as-a-promising-candidate-for-developing-selective-and-effective-anti-cancer-therapies/372483/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ferulic-acid-as-a-promising-candidate-for-developing-selective-and-effective-anti-cancer-therapies/372483.png","ImageObject",300,407,{"name":92,"@type":93},"Melati","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of the review on ferulic acid?","Question",{"text":112,"@type":113},"To summarize the most recent evidence on ferulic acid’s anti-cancer properties, including its effects on multiple cancer cell lines and the mechanisms involved.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which types of cancers are mentioned as common and increasingly diagnosed?",{"text":117,"@type":113},"Breast, colon, lung, and prostate cancers are highlighted as frequently diagnosed cancers whose incidence has been rising.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanisms are described for ferulic acid’s therapeutic potential?",{"text":121,"@type":113},"The review attributes FA’s potential to strong antioxidant free-radical scavenging, anti-inflammatory modulation of pro-inflammatory mediators, and additional antiviral, antimicrobial, and anti-allergic effects, with oncology relevance through apoptosis and pathway interference.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},372483,1791135975,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085570644,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Review  \nFerulic acid as a promising candidate for developing selective and effective anti‑cancer therapies  \nAbdur Rauf1 · RahafAjaj2 · Zuneera Akram3 · Nabia Hafeez4 · Maksim Rebezov5,6 · Mohammad Ali Shariati7 ·  \nAbdullah S. M. Aljohani8 · Muhammad Imran9 · Fahad Tanveer10 · Hassan A. Hemeg11 · Mohammad S. Mubarak12  \nReceived: 16 December 2024 / Accepted: 2 April 2025  \n© The Author(s) 2025 OPEN  \nAbstract  \nPurpose Cancer, a complex and rapidly advancing disease, stands as the second leading cause of death globally. Among the most frequently diagnosed cancers are breast, colon, lung, and prostate cancers. The incidence of these cancers has been rising sharply, a trend attributed partly to the insufficient effectiveness of current therapeutic drugs. This growing challenge has intensified the search for novel anti-cancer agents derived from natural sources.  \nMethods This review covers the most recent literature on FA’s anti-cancer properties. It provides an in-depth analysis offerulic acid’s impact on various cancer cell lines and the mechanisms of action.  \nResults Plants are a rich reservoir of bioactive compounds that offer promising alternatives to synthetic drugs. Among these compounds, alkaloids, flavonoids, stilbenes, curcuminoids, and other phenolic substances have demonstrated significant free radical scavenging activity, suggesting their potential in various therapeutic applications. Ferulic acid (FA) is a hydroxycinnamic acid and phenolic compound found in different plants, fruits, vegetables, and grains. It occurs in exceptionally high concentrations in popcorn and bamboo shoots.  \nConclusion FA exhibits remarkable anti-inflammatory, antioxidant, and anti-cancer properties. Keywords Phenols · Freulic acid · Antioxidant · Anti-inflammatory · Anti-cancer potency  \n* Abdur Rauf, [mashaljcs@yahoo.com](mashaljcs@yahoo.com); * RahafAjaj, [r.ajaj@outlook.com](r.ajaj@outlook.com); [rahaf.ajaj@adu.ac.ae](rahaf.ajaj@adu.ac.ae); Zuneera Akram, [dr.zunaira@baqai.edu.pk](dr.zunaira@baqai.edu.pk); Nabia Hafeez, [nabiahafeez@hotmail.com](nabiahafeez@hotmail.com); Maksim Rebezov, [Rebezov@ya.ru](Rebezov@ya.ru); Mohammad Ali Shariati, [shariatymohammadali@gmail.com](shariatymohammadali@gmail.com); Abdullah S. M. Aljohani, [jhny@qu.edu.sa](jhny@qu.edu.sa); Muhammad Imran, [mic_1661@yahoo.com](mic_1661@yahoo.com); Fahad Tanveer, [hod.rs@giu.edu.pk](hod.rs@giu.edu.pk); Hassan A. Hemeg, [hasanhemeg@hotmail.com](hasanhemeg@hotmail.com); Mohammad S. Mubarak, [mmubarak@ju.edu.jo |](mmubarak@ju.edu.jo |1Department of Chemistry)[1](mmubarak@ju.edu.jo |1Department of Chemistry)[Department of Chemistry](mmubarak@ju.edu.jo |1Department of Chemistry), University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan. 2Department of Environmental and Public Health, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates. 3Department of Pharmacology, Faculty of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan. 4Centre of Biotechnology & Microbiology, University of Peshawar, Peshawar, Pakistan. 5Department of Scientific Research,  \nV. M. Gorbatov Federal Research Center for Food Systems, 26 Talalikhin Str., Moscow 109316, Russia. 6Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, 42 Karl Liebknecht Str., Yekaterinburg 620075, Russia. 7Semey Branch of the Kazakh Research Institute of Processing and Food Industry, Gagarin Avenue 238G, Almaty 050060, Kazakhstan. 8Department of Medical Biosciences, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia. 9Department of Food Science and Technology, University of Narowal, Lahore, Pakistan. 10Department of Rehabilitation Sciences, Green International University, Lahore, Pakistan. 11Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Monawara, Saudi Arabia. 12Department of Chemistry, The University of Jordan, Amman 11942, Jordan.  \nDiscover Oncology  ","cbCaihk6RLQ6zwkW","https://ap.wps.com/l/cbCaihk6RLQ6zwkW","pdf",1301848,21,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Chemical nature and sources of FA\n## Antioxidant and anti-inflammatory mechanisms\n## Antiviral, antimicrobial, and anti-allergic effects\n## Cardiovascular and antithrombotic actions\n## Relevance to oncology","[{\"question\":\"What is the main purpose of the review on ferulic acid?\",\"answer\":\"To summarize the most recent evidence on ferulic acid’s anti-cancer properties, including its effects on multiple cancer cell lines and the mechanisms involved.\"},{\"question\":\"Which types of cancers are mentioned as common and increasingly diagnosed?\",\"answer\":\"Breast, colon, lung, and prostate cancers are highlighted as frequently diagnosed cancers whose incidence has been rising.\"},{\"question\":\"What mechanisms are described for ferulic acid’s therapeutic potential?\",\"answer\":\"The review attributes FA’s potential to strong antioxidant free-radical scavenging, anti-inflammatory modulation of pro-inflammatory mediators, and additional antiviral, antimicrobial, and anti-allergic effects, with oncology relevance through apoptosis and pathway interference.\"}]","Ferulic acid as a promising candidate for developing selective and effective anti-cancer therapies | PDF",1790194629,53]