[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31427":3,"doc-seo-31427":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31427,962075006959,"Anda","https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297",8,"Research & Report","Ferroptosis based on metal–organic frameworks for tumor therapy","Ferroptosis is an iron-dependent, non-apoptotic programmed cell death driven by lipid peroxidation, where reactive oxygen species (ROS) trigger uncontrolled oxidation of polyunsaturated fatty acids and lead to lipid peroxides (LPO) accumulation. Tumor cells can counteract this by maintaining redox and iron-metabolism homeostasis, reducing the effectiveness of ferroptosis-based therapy. Fe- and Cu-based metal–organic frameworks (MOFs) work as nanocarriers and as iron/copper ion carriers that also generate ferroptosis-inducing effects, supporting combined tumor treatments. The review summarizes major advances from the past five years and outlines remaining challenges in stability, targeting, and scalable Fe–MOF preparation.","cbCaiiv4gFMnMnZK","https://ap.wps.com/l/cbCaiiv4gFMnMnZK","pdf",5282808,1,14,"English","en","# Introduction\n## Core concept of ferroptosis\n## Regulatory mechanisms and key regulators\n## Role of redox homeostasis in therapy resistance\n## Iron-ROS-LPO pathway in tumor microenvironments","[{\"question\":\"What is ferroptosis and what drives it?\",\"answer\":\"Ferroptosis is a non-apoptotic programmed cell death driven by iron-dependent lipid peroxidation. It is characterized by ROS-catalyzed oxidation of polyunsaturated fatty acids leading to LPO accumulation.\"},{\"question\":\"Why is ferroptosis-based tumor therapy often limited?\",\"answer\":\"Tumor cells regulate ROS and iron ion levels through redox homeostasis and iron-metabolism homeostasis, preventing oxidative-stress-induced damage and thereby restricting therapeutic efficacy.\"},{\"question\":\"How do Fe- and Cu-based MOFs contribute to tumor ferroptosis therapy?\",\"answer\":\"Fe- and Cu-based MOFs act as nanocarriers for therapeutic cargoes and as iron/copper ion carriers that function as ferroptosis inducers. They can enhance ferroptosis and support combination strategies such as chemotherapy, photodynamic therapy, and immunotherapy.\"}]",1779483638,35,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"ferroptosis-based-on-metalorganic-frameworks-for-tumor-therapy","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/ferroptosis-based-on-metalorganic-frameworks-for-tumor-therapy/31427/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-22",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What is ferroptosis and what drives it?","Question",{"text":73,"@type":74},"Ferroptosis is a non-apoptotic programmed cell death driven by iron-dependent lipid peroxidation. It is characterized by ROS-catalyzed oxidation of polyunsaturated fatty acids leading to LPO accumulation.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"Why is ferroptosis-based tumor therapy often limited?",{"text":78,"@type":74},"Tumor cells regulate ROS and iron ion levels through redox homeostasis and iron-metabolism homeostasis, preventing oxidative-stress-induced damage and thereby restricting therapeutic efficacy.",{"name":80,"@type":71,"acceptedAnswer":81},"How do Fe- and Cu-based MOFs contribute to tumor ferroptosis therapy?",{"text":82,"@type":74},"Fe- and Cu-based MOFs act as nanocarriers for therapeutic cargoes and as iron/copper ion carriers that function as ferroptosis inducers. They can enhance ferroptosis and support combination strategies such as chemotherapy, photodynamic therapy, and immunotherapy.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]