[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379068-105":59,"doc-detail-379068-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ferroptosis-as-a-potential-target-for-cancer-therapy","Ferroptosis as a potential target for cancer therapy","","Ferroptosis is a recently characterized, iron-dependent form of regulated cell death defined by iron overload and lipid peroxidation. Growing studies indicate that ferroptosis functions as a double-edged regulator in human cancers, yet its exact molecular mechanisms and context-specific roles in tumorigenesis remain insufficiently resolved. This review consolidates key ferroptosis pathways, emphasizes regulation and the oncogenic versus tumor-suppressive outcomes across cancers, and summarizes pharmacological ferroptosis activators while outlining future therapeutic targeting strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ferroptosis-as-a-potential-target-for-cancer-therapy/379068/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ferroptosis-as-a-potential-target-for-cancer-therapy/379068.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological features define ferroptosis?","Question",{"text":112,"@type":113},"Ferroptosis is characterized by iron overload and lipid peroxidation, driven by iron-dependent mechanisms involving lipid reactive oxygen species.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is ferroptosis described as a double-edged sword in cancer?",{"text":117,"@type":113},"The review highlights that ferroptosis can act both as an oncogenic event and as a tumor suppressor event depending on the cancer context, although the precise molecular basis is still being clarified.",{"name":119,"@type":110,"acceptedAnswer":120},"How does this review propose targeting ferroptosis for cancer therapy?",{"text":121,"@type":113},"It summarizes key ferroptosis pathways and pharmacological activators, then discusses how targeting ferroptosis may be leveraged in therapeutic strategies, including combining ferroptosis inducers with anti-tumor treatments.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379068,1790626308,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www.nature.com/cddis](www.nature.com/cddis)  \nREVIEW ARTICLE OPEN   \nFerroptosis as a potential target for cancer therapy  \nZhen Chen 1,2,3, Weilong Wang 1,2,3, Siti Razila Abdul Razak2, Tao Han 1,3,4, Nor Hazwani Ahmad 2 ✉ and Xiumin Li 1,3 ✉  \n© The Author(s) 2023  \n\n|  | Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, |  |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| and the prospect of targeting ferroptosis in cancer therapy is further elucidated. |  |  |\n|  | Cell Death and Disease (2023)14:460; [https://doi.org/10.1038/s41419-023-05930-w](https://doi.org/10.1038/s41419-023-05930-w) |  |\n|  |  |  |\n\nFACTS  \n1. Ferroptosis often dysregulated in human cancer.  \n2. Ferroptosis plays a dual role in cancer.  \n3. Ferroptosis provides a promising strategy for cancer therapy.  \nOPEN QUESTIONS  \n1. Why ferroptosis is a double-edged sword in cancer and what is its mechanism?  \n2. What is the mechanism of ncRNAs regulating ferroptosisand whether they can be the targets of ferroptosis?  \n3. In clinical treatment, how to combine ferroptosis inducers with anti-tumor therapy to achieve optimal therapeutic effect?  \nINTRODUCTION  \nIn 2020, there were an estimated 19.3 million new cancer cases and nearly 10 million mortalities due to cancer worldwide [1] . Despite significant advances in treatment, cancer remains the leading cause of death in humans. Furthermore, toxic effects and drug resistance of traditional therapies pose major challenges. Asa result, the search for more effective and tolerable anticancer therapies continues [2] . Ferroptosis was first defined by Brent R. Stockwell in 2012 as an iron-dependent type of cell death that is driven by lipid reactive oxygen species (ROS) [3–5] and is  \nsignificantly different from other regulated cell death forms such as apoptosis [6, 7], autophagy [8, 9], cuproptosis [10, 11], necroptosis [12, 13], and pyroptosis [13, 14] in terms of cell morphology, biochemistry, and genetics (Fig. 1, Fig. 2 and Table 1) . Both the extrinsic pathway and the intrinsic pathway play a crucial role in this process. On the one hand, the extrinsic pathway is activation by inhibition of the cystine-glutamate antiporter (system XC—) . The absorption of extracellular cystine is hindered by the decreased activity of system XC—, which subsequently affects the synthesis of glutathione (GSH) [15] . This reduction in the cell’s antioxidant capacity can result in the accumulation of lipid ROS, thus promoting ferroptosis [15, 16] . In contrast, activation of iron transporters such as serum transferrin and lactotransferrin could trigger the extrinsic pathway. By increasing iron intake and limiting iron loss, these transporters induce ferroptosis via enhancing iron accumulation [15, 17] . The intrinsic pathway is realized by blocking the activation of intracellular antioxidant enzymes. For example, GPX4 can reduce the cytotoxic lipid peroxide (L-OOH) to the corresponding alcohol (L-OH) . Once the activity of GPX4 is inhibited, it will lead to the accumulation of lipid peroxide in the cell membrane [15, 18] . In addition, longchain fatty acid coenzyme A ligase 4 (ACSL4) encourage the incorporation of polyunsaturated fatty acids (PUFA) into phospholipids to form polyunsaturated fatty acid phospholipids (PUFAPL) . PUFA-PLs are susceptible to oxidation induced by free radicals mediated by lipoxygenases","cbCaikaHKRaxd0XM","https://ap.wps.com/l/cbCaikaHKRaxd0XM","pdf",1585499,15,"English","# Facts\n## Key points on ferroptosis in cancer\n# Open questions\n## Mechanisms and clinical integration\n# Introduction\n## Global cancer burden and therapeutic challenges\n## Definition and distinct features of ferroptosis\n## Extrinsic and intrinsic pathway mechanisms\n## Molecular regulators and small-molecule activators","[{\"question\":\"What biological features define ferroptosis?\",\"answer\":\"Ferroptosis is characterized by iron overload and lipid peroxidation, driven by iron-dependent mechanisms involving lipid reactive oxygen species.\"},{\"question\":\"Why is ferroptosis described as a double-edged sword in cancer?\",\"answer\":\"The review highlights that ferroptosis can act both as an oncogenic event and as a tumor suppressor event depending on the cancer context, although the precise molecular basis is still being clarified.\"},{\"question\":\"How does this review propose targeting ferroptosis for cancer therapy?\",\"answer\":\"It summarizes key ferroptosis pathways and pharmacological activators, then discusses how targeting ferroptosis may be leveraged in therapeutic strategies, including combining ferroptosis inducers with anti-tumor treatments.\"}]","Ferroptosis as a potential target for cancer therapy | PDF",1790233973,38]