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Ferroptosis and circular RNAs (circRNAs) have emerged as promising therapeutic directions within the rapidly evolving cancer-therapy landscape. Studies of circRNAs show diverse functions, including regulation of ferroptosis-related molecular pathways. The review evaluates the therapeutic opportunity of targeting circRNAs to trigger ferroptosis and discusses mechanistic routes affecting cell survival, proliferation, and metastasis.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ferroptosis-and-circular-rnas-new-horizons-in-cancer-therapy/332157/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ferroptosis-and-circular-rnas-new-horizons-in-cancer-therapy/332157.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"Why is targeting cancer cells challenging with conventional therapies?","Question",{"text":112,"@type":113},"Cancer’s molecular complexity makes it difficult for approaches like radiation and chemotherapy to selectively target individual cancer cells. This drives interest in more precise and focused treatment strategies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What roles do circRNAs play in cancer-related regulation?",{"text":117,"@type":113},"circRNAs can modulate gene expression and influence molecular control of cellular activities. Their covalently closed-loop structure supports resistance to degradation, enabling regulatory impact.",{"name":119,"@type":110,"acceptedAnswer":120},"How is ferroptosis defined and why is it relevant to cancer?",{"text":121,"@type":113},"Ferroptosis is an iron-dependent form of regulated cell death characterized by lipid peroxide accumulation, leading to membrane damage and cell death. It provides a potential route for targeted destruction of cancer cells.",{"name":123,"@type":110,"acceptedAnswer":124},"How do circRNAs and ferroptosis connect in cancer therapy?",{"text":125,"@type":113},"The review describes that specific circRNAs can regulate ferroptotic pathways and affect cancer-cell fate. Proposed mechanisms include sequestering proteins and interacting with miRNAs to modulate ferroptosis-related processes.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},332157,1790035055,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","Review article:  \nFERROPTOSIS AND CIRCULAR RNAS:  \nNEW HORIZONS IN CANCER THERAPY  \nAsif Ahmad Bhat1, Neelima Kukreti2, Muhammad Afzal3, Ahsas Goyal4, Riya Thapa1, Haider Ali5,6, Moyad Shahwan7,8, Waleed Hassan Almalki9, Imran Kazmi10, Sami I. Alzarea 11, Sachin Kumar Singh 12,13,14, Kamal Dua 13, 15,16,  \nGaurav Gupta1,8  \n1 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, India  \n2 School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India  \n3 Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia  \n4 Institute of Pharmaceutical Research, GLA University, Mathura, U. P., India  \n5 Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India  \n6 Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan  \n7 Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, 346, United Arab Emirates  \n8 Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, Ajman, 346, United Arab Emirates  \n9 Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia  \n10 Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia  \n11 Department of Pharmacology, College of Pharmacy, Jouf University, 72341, Sakaka, Al-Jouf, Saudi Arabia  \n12 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, India  \n13 Faculty of Health, Australian Research Center in Complementary and Integrative Medicine, University of Technology, Sydney, Ultimo-NSW 2007, Australia  \n14 School of Medical and Life Sciences, Sunway University, Sunway, Malaysia  \n15 Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, Ultimo-NSW 2007, Australia  \n16 Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India  \n* Corresponding author: Gaurav Gupta, School of Pharmacy, Suresh Gyan Vihar  \nUniversity, Jagatpura, Mahal Road, Jaipur, India. E-mail: [gauravpharma25@gmail.com](gauravpharma25@gmail.com)  \n[https://dx.doi.org/10.17179/excli2024-7005](https://dx.doi.org/10.17179/excli2024-7005)  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)) .  \nABSTRACT  \nCancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy.  \nExtensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators to pivotal influencers of ferroptosis in cancer cell lines. The results underscore the significance of circRNAs in modulating molecular pathways that impact crucial aspects of cancer development, including cell survival, proliferation, and metastasis. A detailed analysis delineates these pathways, shedding light on the molecular mechanisms through which circRNAs influence ferroptosis. Building upon recent experimental findings, the study evaluates the therapeutic potential of targeting circRNAs to induce ferroptosis. By identifying specific circRNAs associated with the etiology of cancer, this analysis paves the way for the development of targeted therapeutics that exploit vulnerabilities in cancer cells. This review consolidates the existing understanding of ferroptosis and circRNAs, emphasizing their role in cancer therapy and providing impetus for ongoing research in this dynamic field.  \nKeywords: CircRNAs, ferroptosis, cancer treatment, molecular regulation  \nFigure 1: Graphical abstract  \nINTRODUCTION  \nCancer is fundamentally a broad range of disorders characterized by unchecked cell growth, tissue invasion, and a tendency to","cbCaiqwQdYyci8PI","https://ap.wps.com/l/cbCaiqwQdYyci8PI","pdf",1696017,"English","# Introduction\n## Cancer biology and conventional treatment limits\n## ncRNAs, circRNAs, and ferroptosis overview\n## Intersection of ferroptosis and circRNA regulation","[{\"question\":\"Why is targeting cancer cells challenging with conventional therapies?\",\"answer\":\"Cancer’s molecular complexity makes it difficult for approaches like radiation and chemotherapy to selectively target individual cancer cells. This drives interest in more precise and focused treatment strategies.\"},{\"question\":\"What roles do circRNAs play in cancer-related regulation?\",\"answer\":\"circRNAs can modulate gene expression and influence molecular control of cellular activities. Their covalently closed-loop structure supports resistance to degradation, enabling regulatory impact.\"},{\"question\":\"How is ferroptosis defined and why is it relevant to cancer?\",\"answer\":\"Ferroptosis is an iron-dependent form of regulated cell death characterized by lipid peroxide accumulation, leading to membrane damage and cell death. It provides a potential route for targeted destruction of cancer cells.\"},{\"question\":\"How do circRNAs and ferroptosis connect in cancer therapy?\",\"answer\":\"The review describes that specific circRNAs can regulate ferroptotic pathways and affect cancer-cell fate. Proposed mechanisms include sequestering proteins and interacting with miRNAs to modulate ferroptosis-related processes.\"}]","Ferroptosis and Circular RNAs: New Horizons in Cancer Therapy | PDF",1789997085,76]