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Emerging ferroptosis-based strategies aim to selectively engage core pathways driving malignant tumor proliferation and survival, both directly killing tumor cells and counteracting resistance to conventional treatments. The review emphasizes ferroptosis as a dual regulator: lethal lipid peroxidation can suppress tumor progression, while cancers adapt via antioxidant programs. It also examines ferroptosis interactions with the tumor microenvironment, shaping immunogenic cell death and immunosuppressive signaling, and discusses combination approaches to potentiate antitumor immunity despite key challenges.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ferroptosis-a-new-horizon-in-cancer-therapy-review-article/373867/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ferroptosis-a-new-horizon-in-cancer-therapy-review-article/373867.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":56},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is ferroptosis and what triggers it?","Question",{"text":112,"@type":113},"Ferroptosis is an iron-catalyzed regulated cell death mediated by lipid peroxidation. It is initiated by oxidation of polyunsaturated fatty acid–containing phospholipids and amplified by iron-mediated Fenton reactions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can ferroptosis both suppress and be exploited by cancer?",{"text":117,"@type":113},"Ferroptosis suppresses tumor progression through lethal lipid peroxidation, but cancers can co-opt it by activating antioxidant adaptations that counteract ferroptosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic combinations are discussed to enhance antitumor effects?",{"text":121,"@type":113},"The review discusses inducing ferroptosis and integrating it synergistically with chemotherapy, targeted therapy, radiotherapy, hyperthermia therapy, and immunotherapy to suppress progression, overcome resistance, and enhance antitumor immunity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},373867,1790241272,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":56,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review Article  \nFerroptosis: A new horizon in cancer therapy  \nDan Shang1, Linlin Zheng2,3, Jie Chen4, Tian Tan5, Maojin Yao6, Haibin Wu4, Hong Wu1,7, Chenhui Cao1,7, Chuan Xu1,2,3,7  \n1Department of Oncology and Cancer Institute, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China;  \n2Yu-Yue Pathology Scientific Research Center, Chongqing 400039, China;  \n3Jinfeng Laboratory, Chongqing 400039, China;  \n4School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China;  \n5School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China;  \n6The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong 510182, China;  \n7Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.  \nAbstract  \nFerroptosis is an iron-catalyzed form of regulated cell death mediated by lipid peroxidation. Novel ferroptosis-based therapeutic strategies could selectively target core pathways associated with the proliferation and survival of malignant tumors, not only directly inducing tumor cell death but also overcoming resistance to conventional therapies, paving a new path for precision cancer treatment. Ferroptosis suppresses tumor progression through lethal lipid peroxidation, yet is co-opted by cancers through antioxidant adaptations. This review highlights the dual role of ferroptosis in tumor biology and explores the dynamic interplay between ferroptosis and the tumor microenvironment to modulate both immunogenic cell death and immunosuppressive signaling. We discuss the therapeutic potential of ferroptosis induction through synergistic integration with chemotherapy, targeted therapy, radiotherapy, hyperthermia therapy, and immunotherapy to simultaneously suppress tumor progression, overcome resistance mechanisms, and potentiate antitumor immunity, thereby offering innovative strategies to address treatment-refractory malignancies. Challenges include identifying predictive biomarkers, developing tumor-selective ferroptosis inducers, and modulating ferroptosis–immune interactions within the tumor microenvironment. By addressing these issues, ferroptosis has the potential to overcome treatment-resistant and immune-evasive tumors, reshaping oncology therapeutics.  \nKeywords: Ferroptosis; Chemotherapy; Targeted therapy; Radiotherapy; Hyperthermia therapy; Therapy resistance; Immunotherapy  \nIntroduction  \nThe intrinsic heterogeneity of tumors and their dynamically adaptive survival mechanisms have driven the need for innovative precision therapeutic strategies. Ferroptosis—a form of regulated cell death was first formally proposed and coined in 2012 by Dr. Scott J. Dixon and colleagues in Brent R. Stockwell’s laboratory—has garnered significant attention in recent years due to its potential to overcome tumor resistance to conventional therapies [Figure 1]. Distinct from apoptosis and necrosis, ferroptosis is initiated through the oxidation of polyunsaturated fatty acid-containing phospholipids (PUFA-PLs) and amplified by iron-mediated Fenton reactions. [1,2] Ferroptosis activates antigen-presenting cells (APCs) by releasing damage-associated molecular patterns (DAMPs) and depletes immunosuppressive cell populations,[3]  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code: | Website:\u003Cbr>[www.cmj.org](www.cmj.org) |\n|  | DOI:\u003Cbr>10.1097/CM9.0000000000003915 |\n\nfostering an immunostimulatory microenvironment, which highlights the transformative potential of combination therapeutic modalities. [4] The coupling between ferroptosis regulatory networks and tumor metabolic signat","cbCaimqbJOOaR7Jl","https://ap.wps.com/l/cbCaimqbJOOaR7Jl","pdf",6085313,"English","# Introduction\n## Ferroptosis concept and mechanism\n# Abstract overview\n## Dual role in tumor biology\n## Tumor microenvironment interplay\n# Therapeutic strategies\n## Combination modalities and resistance","[{\"question\":\"What is ferroptosis and what triggers it?\",\"answer\":\"Ferroptosis is an iron-catalyzed regulated cell death mediated by lipid peroxidation. It is initiated by oxidation of polyunsaturated fatty acid–containing phospholipids and amplified by iron-mediated Fenton reactions.\"},{\"question\":\"How can ferroptosis both suppress and be exploited by cancer?\",\"answer\":\"Ferroptosis suppresses tumor progression through lethal lipid peroxidation, but cancers can co-opt it by activating antioxidant adaptations that counteract ferroptosis.\"},{\"question\":\"What therapeutic combinations are discussed to enhance antitumor effects?\",\"answer\":\"The review discusses inducing ferroptosis and integrating it synergistically with chemotherapy, targeted therapy, radiotherapy, hyperthermia therapy, and immunotherapy to suppress progression, overcome resistance, and enhance antitumor immunity.\"}]","Ferroptosis: A new horizon in cancer therapy - Review Article | PDF",1790200692,76]