[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-342424-105":59,"doc-detail-342424-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","ferroptosis-a-dual-edged-sword-in-tumour-growth-review","Ferroptosis: a dual-edged sword in tumour growth - review","","Ferroptosis is a recently identified, iron-dependent, non-apoptotic form of cell death driven by lipid peroxidation and iron accumulation, and it is tightly linked to tumour development. The review analyzes how ferroptosis can restrain tumour growth and also promote it, emphasizing the inherent ambivalence of its effects. It surveys therapeutic targets, cancer-cell susceptibility, ways to improve existing anticancer treatments, and the crosstalk between ferroptosis and anti-tumour immunity, alongside core mechanistic pathways guiding ferroptosis-induced tumour progression.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ferroptosis-a-dual-edged-sword-in-tumour-growth-review/342424/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ferroptosis-a-dual-edged-sword-in-tumour-growth-review/342424.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-22",true,{"@type":101,"interactionType":102,"userInteractionCount":8},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is ferroptosis and what distinguishes it from apoptosis?","Question",{"text":111,"@type":112},"Ferroptosis is an iron-dependent non-apoptotic cell death characterized by lipid peroxidation and unstable iron buildup. It differs in morphology, physiology, and biochemistry from classical programmed cell death.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"Why does ferroptosis show a dual role in tumour growth?",{"text":116,"@type":112},"The review explains that ferroptosis can both restrain and promote tumorous proliferation through different pathways. Depending on the context, it may enable tumour control or trigger tumour-promoting processes such as metabolic, inflammatory, immune, and antigen-presentation related mechanisms.",{"name":118,"@type":109,"acceptedAnswer":119},"How can ferroptosis be targeted to improve cancer treatment outcomes?",{"text":120,"@type":112},"The article discusses inducing ferroptosis by disrupting tumour defense mechanisms (e.g., System Xc−, GPX4 activity, and glutathione metabolism) and by regulating lipid and iron metabolism. It also highlights combining ferroptosis with chemotherapy, radiotherapy, targeted therapy, or immunotherapy to enhance efficacy and reduce drug resistance.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},342424,1790072084,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","TYPE Review  \nPUBLISHED 11 January 2024  \nDOI 10.3389/fphar.2023.1330910  \nOPEN ACCESS  \nEDITED BY  \nElisa Giovannetti,  \nVU Medical Center, Netherlands  \nREVIEWED BY  \nChunming Cheng,  \nUniversity of Oklahoma, United States Mahrou Vahabi,  \nVU Medical Center, Netherlands  \n*CORRESPONDENCE  \nYinghui Xu,  \n [xuyinghui@jlu.edu.cn](xuyinghui@jlu.edu.cn)  \nRECEIVED 31 October 2023  \nACCEPTED 27 December 2023  \nPUBLISHED 11 January 2024  \nCITATION  \nZhao X, Li X and Xu Y (2024), Ferroptosis: a dualedged sword in tumour growth.  \nFront. Pharmacol. 14:1330910 .  \ndoi: 10.3389/fphar.2023.1330910  \nCOPYRIGHT  \n© 2024 Zhao, Li and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nFerroptosis: a dual-edged sword in tumour growth  \nXiangye Zhao, Xiaoning Li and Yinghui Xu*  \nCancer Center, The First Hospital of Jilin University, Changchun, Jilin, China  \nFerroptosis, a recently identified form of non-apoptotic cell death, is distinguished by its dependence on iron-triggered lipid peroxidation and accumulation of iron. It has been linked to various disorders, including the development of tumours. Interestingly, ferroptosis appears to exhibit a dual role in the context of tumour growth. This article provides a thorough exploration of the inherent ambivalence within ferroptosis, encompassing both its facilitation and inhibition of tumorous proliferation. It examines potential therapeutic targets associated with ferroptosis, the susceptibility of cancerous cells to ferroptosis, strategies to enhance the efficacy of existing cancer treatments, the interaction between ferroptosis and the immune response to tumours, and the fundamental mechanisms governing ferroptosis-induced tumour progression. A comprehensive understanding of how ferroptosis contributes to tumour biology and the strategic management of its dual nature are crucial for maximizing its therapeutic potential.  \nKEYWORDS  \nferroptosis, tumour, iron, metabolism, antitumour therapy  \n1 Introduction  \nCell death plays a crucial role in maintaining tissue balance and controlling the unregulated growth of tumour cells (Fuchs and Steller, 2011) . However, tumour cells have evolved mechanisms to evade cell death regulation, promoting unchecked cell replication. Ferroptosis, a unique form of non-apoptotic cell death characterised by lipid peroxidation and unstable iron buildup, differs in morphology, physiology, and biochemistry from classical programmed cell death (Dixon et al., 2012; Friedmann Angeli et al., 2014; Stockwell et al., 2017; Hassannia et al., 2019) . An increasing body of evidence implicates ferroptosis in the development of various diseases, including the onset and progression of tumours (Tang et al., 2021) .  \nCurrently, ferroptosis has emerged as a significant focus in oncology research. Most studies suggest a beneficial role in restraining tumour growth through interactions between ferroptosisand tumours (Table 1), highlighting its potential as a therapeutic target in oncology. Tumour cells can bypass ferroptosis to promote their own growth by employing defense mechanisms, such as activating System Xc-, boosting glutathione peroxidase 4 (GPX4) activity, and altering glutathione(GSH)metabolism (Dixon et al.,2012). Disrupting or eliminating these mechanisms can trigger ferroptosis and hinder tumour expansion. Additionally, regulating lipid metabolism and iron metabolism pathways can induce ferroptosis, thereby inhibiting tumour growth (Martinez-Outschoorn et al., 2017; Wolpaw and Dang, 2018; Sang et al., 2019; Zou et al., 2020; Lei et al., 2022). Ferroptosis inducers presents a p","cbCailt9lPM41Sd8","https://ap.wps.com/l/cbCailt9lPM41Sd8","pdf",1467683,13,"English","# Introduction\n## Mechanistic basis and regulation of ferroptosis\n# The mechanism of ferroptosis\n## Lipid peroxidation and oxidative-antioxidant imbalance\n## Role of iron and PUFA oxidation","[{\"question\":\"What is ferroptosis and what distinguishes it from apoptosis?\",\"answer\":\"Ferroptosis is an iron-dependent non-apoptotic cell death characterized by lipid peroxidation and unstable iron buildup. It differs in morphology, physiology, and biochemistry from classical programmed cell death.\"},{\"question\":\"Why does ferroptosis show a dual role in tumour growth?\",\"answer\":\"The review explains that ferroptosis can both restrain and promote tumorous proliferation through different pathways. Depending on the context, it may enable tumour control or trigger tumour-promoting processes such as metabolic, inflammatory, immune, and antigen-presentation related mechanisms.\"},{\"question\":\"How can ferroptosis be targeted to improve cancer treatment outcomes?\",\"answer\":\"The article discusses inducing ferroptosis by disrupting tumour defense mechanisms (e.g., System Xc−, GPX4 activity, and glutathione metabolism) and by regulating lipid and iron metabolism. It also highlights combining ferroptosis with chemotherapy, radiotherapy, targeted therapy, or immunotherapy to enhance efficacy and reduce drug resistance.\"}]","Ferroptosis: a dual-edged sword in tumour growth - review | PDF",1790046571,33]