[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-125032-105":59,"doc-detail-125032-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","fenton-hydroxyl-radical-antioxidant-efficiency-of-ibuprofen-fe3o4-go-nanospheres","Fenton-Hydroxyl Radical Antioxidant Efficiency of Ibuprofen-Fe3O4-GO Nanospheres","","Demonstrates a one-step solvent-antisolvent oil-free acoustic emulsification approach to complex pristine ibuprofen with Fe3O4-GO as core–shell nanospheres (~50 nm). Ultrasonic complexation proceeds through hydrogen-bonding with ibuprofen side chains (CH, CH2, CH3) and C–O–H interactions between carboxylic groups and Fe–O bonds. The resulting ibuprofen-Fe3O4-GO nanospheres show strong antioxidant behavior by hydroxyl radical (·OH) scavenging and iron inactivation in electro-Fenton, achieving ~24× higher diminishing rate than free ibuprofen and ~161× over pristine ibuprofen nanoparticles in aqueous medium.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fenton-hydroxyl-radical-antioxidant-efficiency-of-ibuprofen-fe3o4-go-nanospheres/125032/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fenton-hydroxyl-radical-antioxidant-efficiency-of-ibuprofen-fe3o4-go-nanospheres/125032.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-19","2026-08-05",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What method is used to prepare ibuprofen-Fe3O4-GO nanospheres?","Question",{"text":113,"@type":114},"A one-step solvent-antisolvent oil-free acoustic emulsification method is used to form core–shell ibuprofen-Fe3O4-GO nanospheres (~50 nm).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does ultrasonic complexation occur between ibuprofen and Fe3O4-GO?",{"text":118,"@type":114},"It occurs via hydrogen-bond formation with ibuprofen side chains and through C–O–H interactions involving carboxylic groups and Fe–O bonds.",{"name":120,"@type":111,"acceptedAnswer":121},"What antioxidant performance do the synthesized nanospheres show in electro-Fenton?",{"text":122,"@type":114},"They scavenge hydroxyl radicals and inactivate iron, showing about ~24× higher diminishing rate than free ibuprofen and ~161× higher than pristine ibuprofen nanoparticles in aqueous medium.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},125032,1785896269,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":130,"read_time":24},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Fenton-Hydroxyl Radical Antioxidant Efficiency of Ibuprofen-Fe3O4-GO  \nNanospheres  \nAleksey Drinevskyi1 , Evgenij Zelkovskyi 1 , Vladimir Labunov 1 ,  \nDarya Radziu 1  \n2024  \n1Belarusian State University of Informatics and Radioelectronics, 6 P. Brovki Street, Minsk, 220013 , Belarus.  \nKeywords: graphene oxide, NSAID, iron oxide, ultrasound, metallodrug, Fenton, catalyst.  \nAbstract: A feasible one-step “solvent-antisolvent” oil-free acoustic emulsification method is demonstrated for the complexation of pristine ibuprofen with Fe3O4-GO in the form of nanospheres with a core–shell structure (∼50 nm) . The ultrasonic complexation occurs via the H-bond formation with the ibuprofen side chains (CH, CH2, and CH3) and C– O–H involving the interaction of carboxylic groups and Fe–O bonds. Synthesized ibuprofen-Fe3O4-GO nanospheres are efficient antioxidants with hydroxyl radical (·OH) scavenging and iron inactivation properties in the electro-Fenton process exhibiting ∼24 times higher diminishing rate than free ibuprofen per se and ∼161 times higher than pristine ibuprofen nanoparticles in aqueous medium. This pronounced antioxidant efficiency of ibuprofen-Fe3O4-GO nanospheres is due to the increased concentration of inactive protonated Fe(II) centers in Fe–O, C–Fe, and CO–Fe bonds (FeO+, CFe+, and COFe+) of complexed drug molecules and increased concentration of CHO2+, OH+, and CO+ ions on the surface of nanospheres. The demonstrated method discloses the  \nconditions of enhanced antioxidant efficiency of ibuprofen and defines the roles of Fe3O4 and GO in two basic fundamental COX-independent mechanisms.  \nPublication source: Fenton-Hydroxyl Radical Antioxidant Efficiency of Ibuprofen-Fe3O4-GO / A. Drinevskyi, E. Zelkovskyi, V. Labunov, D. Radziuk // ACS Applied Nano Materials.– 2024.– №7 (3) .– С . 3082– 3095.– DOI: [https://doi.org/10.1021/acsanm.3c05399](https://doi.org/10.1021/acsanm.3c05399) .","cbCaivH2TThcBWyP","https://ap.wps.com/l/cbCaivH2TThcBWyP","pdf",233236,"English","# Abstract and Approach\n## One-step acoustic emulsification\n## Complexation mechanism and structure\n## Antioxidant and electro-Fenton performance","[{\"question\":\"What method is used to prepare ibuprofen-Fe3O4-GO nanospheres?\",\"answer\":\"A one-step solvent-antisolvent oil-free acoustic emulsification method is used to form core–shell ibuprofen-Fe3O4-GO nanospheres (~50 nm).\"},{\"question\":\"How does ultrasonic complexation occur between ibuprofen and Fe3O4-GO?\",\"answer\":\"It occurs via hydrogen-bond formation with ibuprofen side chains and through C–O–H interactions involving carboxylic groups and Fe–O bonds.\"},{\"question\":\"What antioxidant performance do the synthesized nanospheres show in electro-Fenton?\",\"answer\":\"They scavenge hydroxyl radicals and inactivate iron, showing about ~24× higher diminishing rate than free ibuprofen and ~161× higher than pristine ibuprofen nanoparticles in aqueous medium.\"}]","Fenton-Hydroxyl Radical Antioxidant Efficiency of Ibuprofen-Fe3O4-GO Nanospheres | PDF"]