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Using ophthalmological examination and database review (2007–2025) the study identifies five cases with amorphous black conjunctival plaques, including variable concurrent ocular abnormalities. Histopathology shows compaction and brunescence of collagen, absence of fibroblasts, and frequent ulceration with inflammatory infiltration. Chronic irritation and possible FHV-1 contribution are discussed.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/feline-conjunctival-sequestra-a-case-series/432411/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/feline-conjunctival-sequestra-a-case-series/432411.png","ImageObject",300,407,{"name":92,"@type":93},"Jasmine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this case series?","Question",{"text":112,"@type":113},"To describe a series of cases of feline conjunctival sequestrum, a condition not previously documented in the literature.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the cases identified and what was observed during exams?",{"text":117,"@type":113},"After evaluating the first patient, the COPLOW database (2007–2025) was searched for additional cases; all identified cases showed an amorphous black plaque in conjunctival tissue, with three also having ipsilateral corneal sequestra.",{"name":119,"@type":110,"acceptedAnswer":120},"What did histopathology reveal in conjunctival lesions?",{"text":121,"@type":113},"All five conjunctival lesions showed focally extensive compaction and brunescence of proprial collagen with absence of fibroblasts, with surrounding substantia propria variably infiltrated by inflammatory cells and microorganisms.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},432411,1790945636,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},2336478487870,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Veterinary Ophthalmology  \nORIGINAL REPORT  OPEN ACCESS   \nFeline Conjunctival Sequestra—A Case Series  \nCarolina Cauduro da Rosa1 | Brett D. Story2 | Sangwan Park2 | Gillian C. Shaw3 | Leandro B. C. Teixeira3 | Jacob Morris4  | Bret A. Moore4 | Fabiano Montiani-Ferreira1   \n1Comparative Ophthalmology Laboratory, Federal University of Paraná, UFPR, Curitiba, Brazil | 2Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California–Davis, Davis, California, USA | 3Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA | 4Department of Small Animal Clinical Sciences, College of  \nVeterinary Medicine, University of Florida, Gainesville, Florida, USA Correspondence: Fabiano Montiani-Ferreira ([montiani@ufpr.br](montiani@ufpr.br))  \nReceived: 30 April 2025 | Revised: 2 July 2025 | Accepted: 22 July 2025  \nKeywords: cat | conjunctiva | cornea | necrosis | sequestrum  \nABSTRACT  \nPurpose: Corneal sequestrum is a condition commonly observed in cats, though the pathogenesis is not fully understood. The occurrence of conjunctival sequestrum has not previously been documented. This report aims to describe a series of cases of conjunctival sequestra in cats.  \nAnimals and Animal Samples Studied: A 3-year-old male Persian cat presented after 2 months of blepharospasm and epiphorain the right eye, accompanied by mild conjunctival hyperemia. Histopathologic findings from four other cases are also included. Methods: After presentation of Patient 1, the database (from 2007 to 2025) of the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) was searched for other cases of feline conjunctival sequestrum, four of which were identified. In all cases, an amorphous black plaque was observed in the conjunctival tissue during the ophthalmological examination. Three of the four cases also had corneal sequestra ipsilaterally. Histopathology of the corneal sequestra was available in two of the cases. Results: Histopathology of all five conjunctival lesions revealed focally extensive compaction and brunescence of proprial collagen and absence of fibroblasts. Three of the cases had conjunctival ulceration overlying the sequestrum. The surrounding substantia propria was variably infiltrated by inflammatory cells and microorganisms. The appearance of conjunctival sequestrawas remarkably similar to that of corneal sequestra.  \nConclusion and Clinical Relevance: This is the first reported case-series of feline conjunctival sequestrum. Variable presentation of concurrent ocular abnormalities and history led to no definitive conclusion to a common cause. Similar to cornealsequestra, chronic irritation and a possible contribution from FHV-1 infection are suspected.  \n1 | Introduction  \nCornealsequestrum (also known as corneal nigrum, corneal necrosis and corneal mummification) is a condition primarily observed in cats that is characterized by collagen degeneration and the accumulation ofa distinctive brown pigment [1]. Brachycephalic breeds are predisposed to this disorder [2]. Clinical signs commonly include ocular discharge, blepharospasm, corneal ulceration, brownto-black discoloration of the corneal stroma, vascularization, and inflammation [3]. Surgical intervention is typically the preferred  \ntreatment for corneal sequestra, aimed at alleviating patient discomfort and preventing further complications that may include a worsening stromal defect due to infection [4].  \nCorneal lesions are variable, but are most commonly described as discolorations ranging from transparent amber to opaque black, with or without corneal stromal vascularization [5] . Feline corneal sequestra mainly occur unilaterally; however, they may occur bilaterally, either simultaneously or at different times [5] . The pathogenesis of this disease is still unclear, but proposed  \nThis is an open access article under the terms of the Creative Commons Att","cbCaioEFl0QSznMD","https://ap.wps.com/l/cbCaioEFl0QSznMD","pdf",1514313,"English","# Abstract\n# Introduction\n## Corneal sequestrum background\n## Proposed etiologies and histopathology","[{\"question\":\"What is the main purpose of this case series?\",\"answer\":\"To describe a series of cases of feline conjunctival sequestrum, a condition not previously documented in the literature.\"},{\"question\":\"How were the cases identified and what was observed during exams?\",\"answer\":\"After evaluating the first patient, the COPLOW database (2007–2025) was searched for additional cases; all identified cases showed an amorphous black plaque in conjunctival tissue, with three also having ipsilateral corneal sequestra.\"},{\"question\":\"What did histopathology reveal in conjunctival lesions?\",\"answer\":\"All five conjunctival lesions showed focally extensive compaction and brunescence of proprial collagen with absence of fibroblasts, with surrounding substantia propria variably infiltrated by inflammatory cells and microorganisms.\"}]","Feline Conjunctival Sequestra - A Case Series | PDF",1790659484]